Clinical characteristics and rhythm outcome of catheter ablation of hemodynamically corrected valvular atrial fibrillation

Jung Ok Kim, Jaemin Shim, Seung Hyun Lee, Hee Tae Yu, Tae Hoon Kim, Jae Sun Uhm, Jong Il Choi, Jae Young Choi, Moon Hyung Lee, Young Hoon Kim, Byung Chul Chang, Hui Nam Pak

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background: Although the hemodynamic burden and structural substrate contribute to valvular atrial fibrillation (VAF) mechanisms, the role of catheter ablation has rarely been reported. We investigated the clinical characteristics, mapping findings, and long-term rhythm outcomes after catheter ablation of hemodynamically corrected VAF. Methods: We compared 77 patients with VAF (46.8% male, 52.7 ± 8.8 years old, 46.8% paroxysmal AF, 24.7% with maze procedures) and 2244 patients with non-VAF (NVAF) who underwent catheter ablation. Among the VAF patients, 44 (57.1%) had mechanical valve AF (MV-AF) and 33 (42.9%) underwent a prior mitral valvuloplasty (MVP-AF). We analyzed the catheter ablation rhythm outcomes for MV-AF and MVP-AF. Results: The left atrial (LA) diameter was greater (p < 0.001), LA voltage lower (p < 0.001), and procedure-related complication rate higher (mainly sinus node dysfunction, p = 0.004) for VAF than NVAF. During 70.2 ± 1.8 months of follow-up, the rhythm outcome of VAF did not significantly differ from that of NVAF after catheter ablation (log rank p = 0.399), even after excluding patients with maze procedures (log rank p = 0.629). The clinical recurrence rates did not differ between the MV-AF and MVP-AF groups (log rank p = 0.244), or between patients with prior maze procedures and those without (log rank p = 0.651). The main conduction recovery sites of previous maze procedures were the perimitral (84.2%) and cavotricuspid isthmus (84.2%) areas, and recurrence mechanisms were macroreentry (63.2%) and focal/microreentry (26.3%) at scar border zones. Conclusions: Although hemodynamically corrected VAF was associated with advanced LA remodeling, the rhythm outcome did not significantly differ from that of NVAF after catheter ablation.

Original languageEnglish
Pages (from-to)488-496
Number of pages9
JournalJournal of Cardiology
Volume73
Issue number6
DOIs
Publication statusPublished - 2019 Jun

Bibliographical note

Funding Information:
This research was supported by a grant [ HI18C0070 ] from the Korea Health 21 R&D Project, Ministry of Health and Welfare and a grant [ NRF-2017R1A2B4003983 ] from the Basic Science Research Program run by the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT, & Future Planning (MSIP) .

Publisher Copyright:
© 2018 Japanese College of Cardiology

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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