Clinical Characteristics and Surgical Outcomes of Obstructive Sleep Apnea Patients With Mixed Apnea Components

Min Seok Rha, Yeonsu Jeong, Chang Hoon Kim, Joo Heon Yoon, Hyung Ju Cho

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1 Citation (Scopus)


Objective: This study was aimed to investigate clinical implications of mixed apnea (MA) in patients with obstructive sleep apnea (OSA), particularly whether surgical outcomes differ between OSA patients with and without MA events. Study Design: Retrospective cohort study. Setting: Single tertiary medical center. Methods: Eighty-eight patients with OSA who underwent multilevel upper airway surgery were included. Patients were divided into 2 groups according to the presence of MA events: “pure group” (n = 30) and “mixed group” (n = 58). The clinical characteristics and surgical outcomes were compared between the 2 groups. Results: The mixed group included more males (P =.020) and hypertensive patients (P =.009) and had a higher apnea-hypopnea index (AHI; P <.001) than the pure group. The surgical success rate was lower in the mixed group (29.3%) than in the pure group (73.3%; P <.001). Furthermore, the postoperative improvements in total AHI (P <.001), supine AHI (P <.001), and oxygen desaturation index (P =.006) were lower in the mixed group than in the pure group. Logistic regression analysis confirmed that the presence of MA (P =.002) was an independent predictor of poor surgical outcomes in patients with OSA. Conclusion: OSA patients with MA showed different clinical features and poor surgical outcomes compared to those without MA. These results imply that OSA with MA components may have a distinct pathophysiology, and the presence of MA should be considered in the surgical treatment of OSA.

Original languageEnglish
Pages (from-to)521-527
Number of pages7
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number3
Publication statusPublished - 2023 Mar

Bibliographical note

Funding Information:
Funding source: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2021R1A2C2010811), the “Team Science Award” of Yonsei University College of Medicine (6-2021-0005), and Basic Science Research Program through the NRF funded by the Ministry of Education (2021R1I1A1A01047571).

Publisher Copyright:
© 2022 American Academy of Otolaryngology–Head and Neck Surgery Foundation.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology


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