Clinical characteristics and treatment outcomes of colorectal cancer in renal transplant recipients in Korea

Jeong Yeon Kim, Man Ki Ju, Myoung Soo Kim, Nam Kyu Kim, Seung Kook Sohn, Soon Il Kim, Yu Seun Kim

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Purpose: Transplant recipients in Asia appear to be at a higher risk for developing colorectal cancer (CRC). This study was performed to identify the clinicopathological features and oncologic outcomes of CRC in post-renal transplants in Korea. Materials and Methods: We retrospectively reviewed the records of 17 patients with CRC out of 2,630 recipients who underwent renal transplantation between 1994 and 2007. These patients (transplant group) were compared with general CRC patients (n=170, control group) matched, based on the closest date of surgery to the transplant group. Results: During 29.7 months of the median follow- up period, the recurrent and survival rates from recurrence were worse in the transplant group than in the control group (35.2% versus 15.2%; p=0.048 and p=0.025). The 2-year patient survival rate of the transplant group was significantly worse than the control group in advanced cancer (stages III-IV; 45.7% versus 71.6%; p=0.023). In early cancer (stages 0-I), there was no significant difference in 5-year patient survival rate between the two groups (100% versus 92.6%, respectively; p=0.406). Conclusion: In spite of a poor prognosis of advanced CRC in the transplant group, the early stage CRC of the transplant group showed a comparable oncologic outcome compared with the control group. Regular screening and early detection of CRC are essential in the post-transplant setting.

Original languageEnglish
Pages (from-to)454-462
Number of pages9
JournalYonsei medical journal
Volume52
Issue number3
DOIs
Publication statusPublished - 2011 May 1

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Korea
Colorectal Neoplasms
Transplants
Kidney
Control Groups
Survival Rate
Transplant Recipients
Early Detection of Cancer
Kidney Transplantation
Neoplasms
Recurrence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Jeong Yeon ; Ju, Man Ki ; Kim, Myoung Soo ; Kim, Nam Kyu ; Sohn, Seung Kook ; Kim, Soon Il ; Kim, Yu Seun. / Clinical characteristics and treatment outcomes of colorectal cancer in renal transplant recipients in Korea. In: Yonsei medical journal. 2011 ; Vol. 52, No. 3. pp. 454-462.
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abstract = "Purpose: Transplant recipients in Asia appear to be at a higher risk for developing colorectal cancer (CRC). This study was performed to identify the clinicopathological features and oncologic outcomes of CRC in post-renal transplants in Korea. Materials and Methods: We retrospectively reviewed the records of 17 patients with CRC out of 2,630 recipients who underwent renal transplantation between 1994 and 2007. These patients (transplant group) were compared with general CRC patients (n=170, control group) matched, based on the closest date of surgery to the transplant group. Results: During 29.7 months of the median follow- up period, the recurrent and survival rates from recurrence were worse in the transplant group than in the control group (35.2{\%} versus 15.2{\%}; p=0.048 and p=0.025). The 2-year patient survival rate of the transplant group was significantly worse than the control group in advanced cancer (stages III-IV; 45.7{\%} versus 71.6{\%}; p=0.023). In early cancer (stages 0-I), there was no significant difference in 5-year patient survival rate between the two groups (100{\%} versus 92.6{\%}, respectively; p=0.406). Conclusion: In spite of a poor prognosis of advanced CRC in the transplant group, the early stage CRC of the transplant group showed a comparable oncologic outcome compared with the control group. Regular screening and early detection of CRC are essential in the post-transplant setting.",
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Clinical characteristics and treatment outcomes of colorectal cancer in renal transplant recipients in Korea. / Kim, Jeong Yeon; Ju, Man Ki; Kim, Myoung Soo; Kim, Nam Kyu; Sohn, Seung Kook; Kim, Soon Il; Kim, Yu Seun.

In: Yonsei medical journal, Vol. 52, No. 3, 01.05.2011, p. 454-462.

Research output: Contribution to journalReview article

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T1 - Clinical characteristics and treatment outcomes of colorectal cancer in renal transplant recipients in Korea

AU - Kim, Jeong Yeon

AU - Ju, Man Ki

AU - Kim, Myoung Soo

AU - Kim, Nam Kyu

AU - Sohn, Seung Kook

AU - Kim, Soon Il

AU - Kim, Yu Seun

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N2 - Purpose: Transplant recipients in Asia appear to be at a higher risk for developing colorectal cancer (CRC). This study was performed to identify the clinicopathological features and oncologic outcomes of CRC in post-renal transplants in Korea. Materials and Methods: We retrospectively reviewed the records of 17 patients with CRC out of 2,630 recipients who underwent renal transplantation between 1994 and 2007. These patients (transplant group) were compared with general CRC patients (n=170, control group) matched, based on the closest date of surgery to the transplant group. Results: During 29.7 months of the median follow- up period, the recurrent and survival rates from recurrence were worse in the transplant group than in the control group (35.2% versus 15.2%; p=0.048 and p=0.025). The 2-year patient survival rate of the transplant group was significantly worse than the control group in advanced cancer (stages III-IV; 45.7% versus 71.6%; p=0.023). In early cancer (stages 0-I), there was no significant difference in 5-year patient survival rate between the two groups (100% versus 92.6%, respectively; p=0.406). Conclusion: In spite of a poor prognosis of advanced CRC in the transplant group, the early stage CRC of the transplant group showed a comparable oncologic outcome compared with the control group. Regular screening and early detection of CRC are essential in the post-transplant setting.

AB - Purpose: Transplant recipients in Asia appear to be at a higher risk for developing colorectal cancer (CRC). This study was performed to identify the clinicopathological features and oncologic outcomes of CRC in post-renal transplants in Korea. Materials and Methods: We retrospectively reviewed the records of 17 patients with CRC out of 2,630 recipients who underwent renal transplantation between 1994 and 2007. These patients (transplant group) were compared with general CRC patients (n=170, control group) matched, based on the closest date of surgery to the transplant group. Results: During 29.7 months of the median follow- up period, the recurrent and survival rates from recurrence were worse in the transplant group than in the control group (35.2% versus 15.2%; p=0.048 and p=0.025). The 2-year patient survival rate of the transplant group was significantly worse than the control group in advanced cancer (stages III-IV; 45.7% versus 71.6%; p=0.023). In early cancer (stages 0-I), there was no significant difference in 5-year patient survival rate between the two groups (100% versus 92.6%, respectively; p=0.406). Conclusion: In spite of a poor prognosis of advanced CRC in the transplant group, the early stage CRC of the transplant group showed a comparable oncologic outcome compared with the control group. Regular screening and early detection of CRC are essential in the post-transplant setting.

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