Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea

Sook Hee Chung, Sang Un Park, Jae Hee Cheon, Eun Ran Kim, Jeong Sik Byeon, Byong Duk Ye, Bora Keum, Ki Nam Shim, Sung Ae Jung, Jin Oh Kim, Seong Ran Jeon, Hyun Joo Song, Jeong Seop Moon, Dong Kyung Chang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease that is characterized by multiple, recurring small intestinal ulcers with stenosis of unknown causes. The aim of this study was to investigate the clinical characteristics and the treatment outcomes of patients with CMUSE in Korea. Methods: We performed a multicenter study to retrospectively analyze clinical data from 20 patients who suffered from CMUSE between 1984 and 2012. Their clinical characteristics and long-term disease courses were investigated. Results: The most common initial symptom of CMUSE was abdominal pain (14/20, 70 %). Small bowel series (13/20, 65 %), double-balloon enteroscopy (12/20, 60 %), CT enterography (12/20, 60 %), and capsule endoscopy (10/20, 50 %) were used to diagnose CMUSE. The strictures of the patients were located in the jejunum (5/20, 25 %), ileum (7/20, 35 %), and both jejunum and ileum (6/20, 30 %). The number of patients in a state of remission, persistent disease, and relapse at the end of follow-up were 13/20 (65 %), 2/20 (10 %), and 5/20 (25 %), respectively. The median relapse-free survival was of 67.1 months. Seventy-five percent relapse-free survivals for female and male patients were 93 and 9 months, respectively (P = 0.031). Conclusion: CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.

Original languageEnglish
Pages (from-to)2740-2745
Number of pages6
JournalDigestive diseases and sciences
Volume60
Issue number9
DOIs
Publication statusPublished - 2015 Sep 22

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Enteritis
Korea
Recurrence
Jejunum
Ileum
Pathologic Constriction
Double-Balloon Enteroscopy
Capsule Endoscopy
Survival
Rare Diseases
Abdominal Pain
Multicenter Studies
Ulcer

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Chung, Sook Hee ; Park, Sang Un ; Cheon, Jae Hee ; Kim, Eun Ran ; Byeon, Jeong Sik ; Ye, Byong Duk ; Keum, Bora ; Shim, Ki Nam ; Jung, Sung Ae ; Kim, Jin Oh ; Jeon, Seong Ran ; Song, Hyun Joo ; Moon, Jeong Seop ; Chang, Dong Kyung. / Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea. In: Digestive diseases and sciences. 2015 ; Vol. 60, No. 9. pp. 2740-2745.
@article{50c5b3b90d89492fbad649a3431f998d,
title = "Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea",
abstract = "Background: Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease that is characterized by multiple, recurring small intestinal ulcers with stenosis of unknown causes. The aim of this study was to investigate the clinical characteristics and the treatment outcomes of patients with CMUSE in Korea. Methods: We performed a multicenter study to retrospectively analyze clinical data from 20 patients who suffered from CMUSE between 1984 and 2012. Their clinical characteristics and long-term disease courses were investigated. Results: The most common initial symptom of CMUSE was abdominal pain (14/20, 70 {\%}). Small bowel series (13/20, 65 {\%}), double-balloon enteroscopy (12/20, 60 {\%}), CT enterography (12/20, 60 {\%}), and capsule endoscopy (10/20, 50 {\%}) were used to diagnose CMUSE. The strictures of the patients were located in the jejunum (5/20, 25 {\%}), ileum (7/20, 35 {\%}), and both jejunum and ileum (6/20, 30 {\%}). The number of patients in a state of remission, persistent disease, and relapse at the end of follow-up were 13/20 (65 {\%}), 2/20 (10 {\%}), and 5/20 (25 {\%}), respectively. The median relapse-free survival was of 67.1 months. Seventy-five percent relapse-free survivals for female and male patients were 93 and 9 months, respectively (P = 0.031). Conclusion: CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.",
author = "Chung, {Sook Hee} and Park, {Sang Un} and Cheon, {Jae Hee} and Kim, {Eun Ran} and Byeon, {Jeong Sik} and Ye, {Byong Duk} and Bora Keum and Shim, {Ki Nam} and Jung, {Sung Ae} and Kim, {Jin Oh} and Jeon, {Seong Ran} and Song, {Hyun Joo} and Moon, {Jeong Seop} and Chang, {Dong Kyung}",
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doi = "10.1007/s10620-015-3595-y",
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Chung, SH, Park, SU, Cheon, JH, Kim, ER, Byeon, JS, Ye, BD, Keum, B, Shim, KN, Jung, SA, Kim, JO, Jeon, SR, Song, HJ, Moon, JS & Chang, DK 2015, 'Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea', Digestive diseases and sciences, vol. 60, no. 9, pp. 2740-2745. https://doi.org/10.1007/s10620-015-3595-y

Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea. / Chung, Sook Hee; Park, Sang Un; Cheon, Jae Hee; Kim, Eun Ran; Byeon, Jeong Sik; Ye, Byong Duk; Keum, Bora; Shim, Ki Nam; Jung, Sung Ae; Kim, Jin Oh; Jeon, Seong Ran; Song, Hyun Joo; Moon, Jeong Seop; Chang, Dong Kyung.

In: Digestive diseases and sciences, Vol. 60, No. 9, 22.09.2015, p. 2740-2745.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea

AU - Chung, Sook Hee

AU - Park, Sang Un

AU - Cheon, Jae Hee

AU - Kim, Eun Ran

AU - Byeon, Jeong Sik

AU - Ye, Byong Duk

AU - Keum, Bora

AU - Shim, Ki Nam

AU - Jung, Sung Ae

AU - Kim, Jin Oh

AU - Jeon, Seong Ran

AU - Song, Hyun Joo

AU - Moon, Jeong Seop

AU - Chang, Dong Kyung

PY - 2015/9/22

Y1 - 2015/9/22

N2 - Background: Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease that is characterized by multiple, recurring small intestinal ulcers with stenosis of unknown causes. The aim of this study was to investigate the clinical characteristics and the treatment outcomes of patients with CMUSE in Korea. Methods: We performed a multicenter study to retrospectively analyze clinical data from 20 patients who suffered from CMUSE between 1984 and 2012. Their clinical characteristics and long-term disease courses were investigated. Results: The most common initial symptom of CMUSE was abdominal pain (14/20, 70 %). Small bowel series (13/20, 65 %), double-balloon enteroscopy (12/20, 60 %), CT enterography (12/20, 60 %), and capsule endoscopy (10/20, 50 %) were used to diagnose CMUSE. The strictures of the patients were located in the jejunum (5/20, 25 %), ileum (7/20, 35 %), and both jejunum and ileum (6/20, 30 %). The number of patients in a state of remission, persistent disease, and relapse at the end of follow-up were 13/20 (65 %), 2/20 (10 %), and 5/20 (25 %), respectively. The median relapse-free survival was of 67.1 months. Seventy-five percent relapse-free survivals for female and male patients were 93 and 9 months, respectively (P = 0.031). Conclusion: CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.

AB - Background: Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease that is characterized by multiple, recurring small intestinal ulcers with stenosis of unknown causes. The aim of this study was to investigate the clinical characteristics and the treatment outcomes of patients with CMUSE in Korea. Methods: We performed a multicenter study to retrospectively analyze clinical data from 20 patients who suffered from CMUSE between 1984 and 2012. Their clinical characteristics and long-term disease courses were investigated. Results: The most common initial symptom of CMUSE was abdominal pain (14/20, 70 %). Small bowel series (13/20, 65 %), double-balloon enteroscopy (12/20, 60 %), CT enterography (12/20, 60 %), and capsule endoscopy (10/20, 50 %) were used to diagnose CMUSE. The strictures of the patients were located in the jejunum (5/20, 25 %), ileum (7/20, 35 %), and both jejunum and ileum (6/20, 30 %). The number of patients in a state of remission, persistent disease, and relapse at the end of follow-up were 13/20 (65 %), 2/20 (10 %), and 5/20 (25 %), respectively. The median relapse-free survival was of 67.1 months. Seventy-five percent relapse-free survivals for female and male patients were 93 and 9 months, respectively (P = 0.031). Conclusion: CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.

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U2 - 10.1007/s10620-015-3595-y

DO - 10.1007/s10620-015-3595-y

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