Clinical characteristics of patients with tuberculosis-destroyed lung

C. K. Rhee, K. H. Yoo, J. H. Lee, M. J. Park, W. J. Kim, Y. B. Park, Y. I. Hwang, Y. S. Kim, J. Y. Jung, J. Y. Moon, Y. K. Rhee, H. K. Park, J. H. Lim, H. Y. Park, S. W. Lee, Y. H. Kim, S. H. Lee, H. K. Yoon, J. W. Kim, J. S. KimY. K. Kim, Y. M. Oh, Sang Do Lee, H. J. Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

SETTING: Multicentre study. OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB. DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011. RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 (%) and number of exacerbations during follow-up were independent factors affecting change in FEV1. CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung.

Original languageEnglish
Pages (from-to)67-75+i
JournalInternational Journal of Tuberculosis and Lung Disease
Volume17
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Forced Expiratory Volume
Tuberculosis
Lung
Vital Capacity
Muscarinic Antagonists
Bronchodilator Agents
Multicenter Studies
Adrenal Cortex Hormones
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Rhee, C. K., Yoo, K. H., Lee, J. H., Park, M. J., Kim, W. J., Park, Y. B., ... Kim, H. J. (2013). Clinical characteristics of patients with tuberculosis-destroyed lung. International Journal of Tuberculosis and Lung Disease, 17(1), 67-75+i. https://doi.org/10.5588/ijtld.12.0351
Rhee, C. K. ; Yoo, K. H. ; Lee, J. H. ; Park, M. J. ; Kim, W. J. ; Park, Y. B. ; Hwang, Y. I. ; Kim, Y. S. ; Jung, J. Y. ; Moon, J. Y. ; Rhee, Y. K. ; Park, H. K. ; Lim, J. H. ; Park, H. Y. ; Lee, S. W. ; Kim, Y. H. ; Lee, S. H. ; Yoon, H. K. ; Kim, J. W. ; Kim, J. S. ; Kim, Y. K. ; Oh, Y. M. ; Lee, Sang Do ; Kim, H. J. / Clinical characteristics of patients with tuberculosis-destroyed lung. In: International Journal of Tuberculosis and Lung Disease. 2013 ; Vol. 17, No. 1. pp. 67-75+i.
@article{6a88988ac9bc48b8a44b3bb0c773b0d3,
title = "Clinical characteristics of patients with tuberculosis-destroyed lung",
abstract = "SETTING: Multicentre study. OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB. DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011. RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5{\%} were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1{\%} of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26{\%} ± 0.79), 1.16 ± 0.02 l (49.05{\%} ± 0.84), 58.03{\%} ± 0.70, 5.70{\%} ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 ({\%}) and number of exacerbations during follow-up were independent factors affecting change in FEV1. CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung.",
author = "Rhee, {C. K.} and Yoo, {K. H.} and Lee, {J. H.} and Park, {M. J.} and Kim, {W. J.} and Park, {Y. B.} and Hwang, {Y. I.} and Kim, {Y. S.} and Jung, {J. Y.} and Moon, {J. Y.} and Rhee, {Y. K.} and Park, {H. K.} and Lim, {J. H.} and Park, {H. Y.} and Lee, {S. W.} and Kim, {Y. H.} and Lee, {S. H.} and Yoon, {H. K.} and Kim, {J. W.} and Kim, {J. S.} and Kim, {Y. K.} and Oh, {Y. M.} and Lee, {Sang Do} and Kim, {H. J.}",
year = "2013",
month = "1",
day = "1",
doi = "10.5588/ijtld.12.0351",
language = "English",
volume = "17",
pages = "67--75+i",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "1",

}

Rhee, CK, Yoo, KH, Lee, JH, Park, MJ, Kim, WJ, Park, YB, Hwang, YI, Kim, YS, Jung, JY, Moon, JY, Rhee, YK, Park, HK, Lim, JH, Park, HY, Lee, SW, Kim, YH, Lee, SH, Yoon, HK, Kim, JW, Kim, JS, Kim, YK, Oh, YM, Lee, SD & Kim, HJ 2013, 'Clinical characteristics of patients with tuberculosis-destroyed lung', International Journal of Tuberculosis and Lung Disease, vol. 17, no. 1, pp. 67-75+i. https://doi.org/10.5588/ijtld.12.0351

Clinical characteristics of patients with tuberculosis-destroyed lung. / Rhee, C. K.; Yoo, K. H.; Lee, J. H.; Park, M. J.; Kim, W. J.; Park, Y. B.; Hwang, Y. I.; Kim, Y. S.; Jung, J. Y.; Moon, J. Y.; Rhee, Y. K.; Park, H. K.; Lim, J. H.; Park, H. Y.; Lee, S. W.; Kim, Y. H.; Lee, S. H.; Yoon, H. K.; Kim, J. W.; Kim, J. S.; Kim, Y. K.; Oh, Y. M.; Lee, Sang Do; Kim, H. J.

In: International Journal of Tuberculosis and Lung Disease, Vol. 17, No. 1, 01.01.2013, p. 67-75+i.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical characteristics of patients with tuberculosis-destroyed lung

AU - Rhee, C. K.

AU - Yoo, K. H.

AU - Lee, J. H.

AU - Park, M. J.

AU - Kim, W. J.

AU - Park, Y. B.

AU - Hwang, Y. I.

AU - Kim, Y. S.

AU - Jung, J. Y.

AU - Moon, J. Y.

AU - Rhee, Y. K.

AU - Park, H. K.

AU - Lim, J. H.

AU - Park, H. Y.

AU - Lee, S. W.

AU - Kim, Y. H.

AU - Lee, S. H.

AU - Yoon, H. K.

AU - Kim, J. W.

AU - Kim, J. S.

AU - Kim, Y. K.

AU - Oh, Y. M.

AU - Lee, Sang Do

AU - Kim, H. J.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - SETTING: Multicentre study. OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB. DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011. RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 (%) and number of exacerbations during follow-up were independent factors affecting change in FEV1. CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung.

AB - SETTING: Multicentre study. OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB. DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011. RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 (%) and number of exacerbations during follow-up were independent factors affecting change in FEV1. CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung.

UR - http://www.scopus.com/inward/record.url?scp=84871255203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871255203&partnerID=8YFLogxK

U2 - 10.5588/ijtld.12.0351

DO - 10.5588/ijtld.12.0351

M3 - Article

C2 - 23232006

AN - SCOPUS:84871255203

VL - 17

SP - 67-75+i

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 1

ER -