Abstract
This study was done to analyze the clinical characteristics of renal cell carcinoma (RCC) in Korean patients with von Hippel-Lindau (VHL) disease. Between January 1996 and July 2008, 1,514 patients were diagnosed with RCC and 24 patients were diagnosed with VHL disease at our institute. We analyzed the clinical characteristics of the 24 patients diagnosed with VHL. The mean age of patients with VHL was 39.2±12.6 yr; the mean age of patients with both VHL and RCC was 42.5±10.3 yr. Among the 24 patients with VHL, 7 patients had retinal angiomas, 11 had RCC, 16 had renal lesions, 18 had pancreatic lesions and 21 had cerebellar hemangioblastomas. There was no significant difference between survival rates of patients with VHL alone and those with VHL and RCC. However, cancer-specific survival rates were significantly different between patients with both VHL and RCC and patients with sporadic bilateral or multifocal RCC. In our Korean study, the incidence of RCC in patients with VHL disease is 45.8% and the incidence of VHL disease in patients with RCC is 0.73%. Due to the low overall incidence of VHL in Korea, extended multiinstitutional studies are needed to establish the true characteristics of VHL disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1145-1149 |
| Number of pages | 5 |
| Journal | Journal of Korean medical science |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2009 Dec 1 |
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- Medicine(all)
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Clinical characteristics of renal cell carcinoma in Korean patients with von Hippel-Lindau disease compared to sporadic bilateral or multifocal renal cell carcinoma. / Kim, Won Tae; Ham, Won Sik; Ju, Hee Jeong; Lee, Jin Sun; Lee, Jin Sung; Choi, Young Deuk.
In: Journal of Korean medical science, Vol. 24, No. 6, 01.12.2009, p. 1145-1149.Research output: Contribution to journal › Article
TY - JOUR
T1 - Clinical characteristics of renal cell carcinoma in Korean patients with von Hippel-Lindau disease compared to sporadic bilateral or multifocal renal cell carcinoma
AU - Kim, Won Tae
AU - Ham, Won Sik
AU - Ju, Hee Jeong
AU - Lee, Jin Sun
AU - Lee, Jin Sung
AU - Choi, Young Deuk
PY - 2009/12/1
Y1 - 2009/12/1
N2 - This study was done to analyze the clinical characteristics of renal cell carcinoma (RCC) in Korean patients with von Hippel-Lindau (VHL) disease. Between January 1996 and July 2008, 1,514 patients were diagnosed with RCC and 24 patients were diagnosed with VHL disease at our institute. We analyzed the clinical characteristics of the 24 patients diagnosed with VHL. The mean age of patients with VHL was 39.2±12.6 yr; the mean age of patients with both VHL and RCC was 42.5±10.3 yr. Among the 24 patients with VHL, 7 patients had retinal angiomas, 11 had RCC, 16 had renal lesions, 18 had pancreatic lesions and 21 had cerebellar hemangioblastomas. There was no significant difference between survival rates of patients with VHL alone and those with VHL and RCC. However, cancer-specific survival rates were significantly different between patients with both VHL and RCC and patients with sporadic bilateral or multifocal RCC. In our Korean study, the incidence of RCC in patients with VHL disease is 45.8% and the incidence of VHL disease in patients with RCC is 0.73%. Due to the low overall incidence of VHL in Korea, extended multiinstitutional studies are needed to establish the true characteristics of VHL disease.
AB - This study was done to analyze the clinical characteristics of renal cell carcinoma (RCC) in Korean patients with von Hippel-Lindau (VHL) disease. Between January 1996 and July 2008, 1,514 patients were diagnosed with RCC and 24 patients were diagnosed with VHL disease at our institute. We analyzed the clinical characteristics of the 24 patients diagnosed with VHL. The mean age of patients with VHL was 39.2±12.6 yr; the mean age of patients with both VHL and RCC was 42.5±10.3 yr. Among the 24 patients with VHL, 7 patients had retinal angiomas, 11 had RCC, 16 had renal lesions, 18 had pancreatic lesions and 21 had cerebellar hemangioblastomas. There was no significant difference between survival rates of patients with VHL alone and those with VHL and RCC. However, cancer-specific survival rates were significantly different between patients with both VHL and RCC and patients with sporadic bilateral or multifocal RCC. In our Korean study, the incidence of RCC in patients with VHL disease is 45.8% and the incidence of VHL disease in patients with RCC is 0.73%. Due to the low overall incidence of VHL in Korea, extended multiinstitutional studies are needed to establish the true characteristics of VHL disease.
UR - http://www.scopus.com/inward/record.url?scp=75349100778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75349100778&partnerID=8YFLogxK
U2 - 10.3346/jkms.2009.24.6.1145
DO - 10.3346/jkms.2009.24.6.1145
M3 - Article
C2 - 19949673
AN - SCOPUS:75349100778
VL - 24
SP - 1145
EP - 1149
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 6
ER -