Clinical differences in patients infected with fusobacterium and antimicrobial susceptibility of fusobacterium isolates recovered at a tertiary-care hospital in korea

Myungsook Kim, Shin Young Yun, Yunhee Lee, Hyukmin Lee, Dongeun Yong, Kyungwon Lee

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Abstract

Background: Fusobacterium species are obligately anaerobic, gram-negative bacilli. Especially, F. nucleatum and F. necrophorum are highly relevant human pathogens. We investigated clinical differences in patients infected with Fusobacterium spp. and determined the antimicrobial susceptibility of Fusobacterium isolates. Methods: We collected clinical data of 86 patients from whom Fusobacterium spp. were isolated from clinical specimens at a tertiary-care hospital in Korea between 2003 and 2020. In total, 76 non-duplicated Fusobacterium isolates were selected for antimicrobial susceptibility testing by the agar dilution method, according to the Clinical and Laboratory Standards Institute guidelines (M11-A9). Results: F. nucleatum was most frequently isolated from blood cultures and was associated with hematologic malignancy, whereas F. necrophorum was mostly prevalent in head and neck infections. Anti-anaerobic agents were more commonly used to treat F. nucleatum and F. varium infections than to treat F. necrophorum infections. We observed no significant difference in mortality between patients infected with these species. All F. nucleatum and F. necrophorum isolates were susceptible to the antimicrobial agents tested. F. varium was resistant to clindamycin (48%) and moxifloxacin (24%), and F. mortiferum was resistant to penicillin G (22%) and ceftriaxone (67%). β-Lactamase activity was not detected. Conclusions: Despite the clinical differences among patients with clinically important Fusobacterium infections, there was no significant difference in the mortality rates. Some Fusobacterium spp. were resistant to penicillin G, ceftriaxone, clindamycin, or moxifloxacin. This study may provide clinically relevant data for implementing empirical treatment against Fusobacterium infections.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalAnnals of laboratory medicine
Volume42
Issue number2
DOIs
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This study was supported by a faculty research grant from the Yonsei University College of Medicine awarded to KL (No. 6-2016-0071).

Publisher Copyright:
© 2022 Seoul National University, Institute for Cognitive Science. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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