Clinical diversity of atopic dermatitis

A review of 5,000 patients at a single institute

Howard Chu, Jung U. Shin, Chang Ook Park, Hemin Lee, Jungsoo Lee, Kwanghoon Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: Atopic dermatitis (AD) is a chronic eczematous dermatitis that has a high prevalence and diverse clinical features. Although several hypotheses about its multifactorial pathogenesis have been suggested, the cause is not yet fully understood. A better understanding of the clinical features may helpful inelucidating the pathogenesis of AD. Methods: This retrospective study analyzed the questionnaires, medical charts, and laboratory examination results of 5,000 patients diagnosed with AD at a single tertiary hospital in Korea. Results: The demographics, allergic comorbidities, family history, severity, and treatment experiences of the patients were analyzed. Most of the patients were adults, 76.3% of whom were classified as havingan extrinsic type of AD. The mean eczema area and severity index (EASI) score was found to be 13.68, and adult patients were found to have higher severity than the other age groups. The anatomical involvements were different among the age groups, with more involvements of the head and neck in adults. The patients reported seasonal changes and stress as the factors that aggravated their symptoms the most. Topical steroids and oral cyclosporine were the most used medications at our clinic, whereas 10.1% of the patients underwent allergen-specific immunotherapy. Conclusions: This analysis of 5,000 patients would lead to a better understanding of various subtypes and diverse clinical features of AD in Koreans. Distinct characteristics were observed among different age groups; thus, treatment strategies may need to be differentiated accordingly.

Original languageEnglish
Pages (from-to)158-168
Number of pages11
JournalAllergy, Asthma and Immunology Research
Volume9
Issue number2
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Atopic Dermatitis
Age Groups
Eczema
Immunologic Desensitization
Korea
Tertiary Care Centers
Cyclosporine
Comorbidity
Neck
Retrospective Studies
Steroids
Head
Demography
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Chu, Howard ; Shin, Jung U. ; Park, Chang Ook ; Lee, Hemin ; Lee, Jungsoo ; Lee, Kwanghoon. / Clinical diversity of atopic dermatitis : A review of 5,000 patients at a single institute. In: Allergy, Asthma and Immunology Research. 2017 ; Vol. 9, No. 2. pp. 158-168.
@article{0414e698f27b4bc9999fe734ab6c72bf,
title = "Clinical diversity of atopic dermatitis: A review of 5,000 patients at a single institute",
abstract = "Purpose: Atopic dermatitis (AD) is a chronic eczematous dermatitis that has a high prevalence and diverse clinical features. Although several hypotheses about its multifactorial pathogenesis have been suggested, the cause is not yet fully understood. A better understanding of the clinical features may helpful inelucidating the pathogenesis of AD. Methods: This retrospective study analyzed the questionnaires, medical charts, and laboratory examination results of 5,000 patients diagnosed with AD at a single tertiary hospital in Korea. Results: The demographics, allergic comorbidities, family history, severity, and treatment experiences of the patients were analyzed. Most of the patients were adults, 76.3{\%} of whom were classified as havingan extrinsic type of AD. The mean eczema area and severity index (EASI) score was found to be 13.68, and adult patients were found to have higher severity than the other age groups. The anatomical involvements were different among the age groups, with more involvements of the head and neck in adults. The patients reported seasonal changes and stress as the factors that aggravated their symptoms the most. Topical steroids and oral cyclosporine were the most used medications at our clinic, whereas 10.1{\%} of the patients underwent allergen-specific immunotherapy. Conclusions: This analysis of 5,000 patients would lead to a better understanding of various subtypes and diverse clinical features of AD in Koreans. Distinct characteristics were observed among different age groups; thus, treatment strategies may need to be differentiated accordingly.",
author = "Howard Chu and Shin, {Jung U.} and Park, {Chang Ook} and Hemin Lee and Jungsoo Lee and Kwanghoon Lee",
year = "2017",
month = "1",
day = "1",
doi = "10.4168/aair.2017.9.2.158",
language = "English",
volume = "9",
pages = "158--168",
journal = "Allergy, Asthma and Immunology Research",
issn = "2092-7355",
publisher = "Korean Academy of Asthma, Allergy and Clinical Immunology",
number = "2",

}

Clinical diversity of atopic dermatitis : A review of 5,000 patients at a single institute. / Chu, Howard; Shin, Jung U.; Park, Chang Ook; Lee, Hemin; Lee, Jungsoo; Lee, Kwanghoon.

In: Allergy, Asthma and Immunology Research, Vol. 9, No. 2, 01.01.2017, p. 158-168.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical diversity of atopic dermatitis

T2 - A review of 5,000 patients at a single institute

AU - Chu, Howard

AU - Shin, Jung U.

AU - Park, Chang Ook

AU - Lee, Hemin

AU - Lee, Jungsoo

AU - Lee, Kwanghoon

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Purpose: Atopic dermatitis (AD) is a chronic eczematous dermatitis that has a high prevalence and diverse clinical features. Although several hypotheses about its multifactorial pathogenesis have been suggested, the cause is not yet fully understood. A better understanding of the clinical features may helpful inelucidating the pathogenesis of AD. Methods: This retrospective study analyzed the questionnaires, medical charts, and laboratory examination results of 5,000 patients diagnosed with AD at a single tertiary hospital in Korea. Results: The demographics, allergic comorbidities, family history, severity, and treatment experiences of the patients were analyzed. Most of the patients were adults, 76.3% of whom were classified as havingan extrinsic type of AD. The mean eczema area and severity index (EASI) score was found to be 13.68, and adult patients were found to have higher severity than the other age groups. The anatomical involvements were different among the age groups, with more involvements of the head and neck in adults. The patients reported seasonal changes and stress as the factors that aggravated their symptoms the most. Topical steroids and oral cyclosporine were the most used medications at our clinic, whereas 10.1% of the patients underwent allergen-specific immunotherapy. Conclusions: This analysis of 5,000 patients would lead to a better understanding of various subtypes and diverse clinical features of AD in Koreans. Distinct characteristics were observed among different age groups; thus, treatment strategies may need to be differentiated accordingly.

AB - Purpose: Atopic dermatitis (AD) is a chronic eczematous dermatitis that has a high prevalence and diverse clinical features. Although several hypotheses about its multifactorial pathogenesis have been suggested, the cause is not yet fully understood. A better understanding of the clinical features may helpful inelucidating the pathogenesis of AD. Methods: This retrospective study analyzed the questionnaires, medical charts, and laboratory examination results of 5,000 patients diagnosed with AD at a single tertiary hospital in Korea. Results: The demographics, allergic comorbidities, family history, severity, and treatment experiences of the patients were analyzed. Most of the patients were adults, 76.3% of whom were classified as havingan extrinsic type of AD. The mean eczema area and severity index (EASI) score was found to be 13.68, and adult patients were found to have higher severity than the other age groups. The anatomical involvements were different among the age groups, with more involvements of the head and neck in adults. The patients reported seasonal changes and stress as the factors that aggravated their symptoms the most. Topical steroids and oral cyclosporine were the most used medications at our clinic, whereas 10.1% of the patients underwent allergen-specific immunotherapy. Conclusions: This analysis of 5,000 patients would lead to a better understanding of various subtypes and diverse clinical features of AD in Koreans. Distinct characteristics were observed among different age groups; thus, treatment strategies may need to be differentiated accordingly.

UR - http://www.scopus.com/inward/record.url?scp=85014117448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014117448&partnerID=8YFLogxK

U2 - 10.4168/aair.2017.9.2.158

DO - 10.4168/aair.2017.9.2.158

M3 - Article

VL - 9

SP - 158

EP - 168

JO - Allergy, Asthma and Immunology Research

JF - Allergy, Asthma and Immunology Research

SN - 2092-7355

IS - 2

ER -