Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus: A prospective, placebo-controlled, multicenter study

Hyun Jin Lee, Min Beom Kim, Shin Young Yoo, Shi Nae Park, Eui Cheol Nam, In Seok Moon, Ho Ki Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin. Study Design: A prospective, randomized, placebo-controlled, double-blinded, multicenter study. Methods: Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization. Intratympanic injections were administered four times over 2 weeks. At 4 weeks after initial injection, we analyzed the improvement rates of tinnitus using the tinnitus handicap Inventory (THI) and visual analogue scale (VAS) for loudness, awareness, and annoyance. We defined improvement as the reduction of more than 7 points or of more than 20% in the final THI score compared to the initial THI score. Results: The initial mean hearing thresholds and VAS and THI scores of the two groups did not differ significantly. At 4 weeks after initial injection, the mean VAS and THI scores of both groups had significantly reduced. However, the improvement rate did not differ significantly between the groups (ITDI, 51.9%; ITNI, 59.3%). Conclusion: The results indicate that ITDI might not be more effective than ITNI for the treatment of acute unilateral tinnitus. Therefore, ITDI should not be considered as the main treatment for patients presenting with acute tinnitus as the primary symptom. Level of Evidence: 1b. Laryngoscope, 128:184–188, 2018.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalLaryngoscope
Volume128
Issue number1
DOIs
Publication statusPublished - 2018 Jan

Fingerprint

Tinnitus
Dexamethasone
Multicenter Studies
Placebos
Equipment and Supplies
Visual Analog Scale
Injections
Intratympanic Injection
Laryngoscopes
Cochlea
Random Allocation
Hearing

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Lee, Hyun Jin ; Kim, Min Beom ; Yoo, Shin Young ; Park, Shi Nae ; Nam, Eui Cheol ; Moon, In Seok ; Lee, Ho Ki. / Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus : A prospective, placebo-controlled, multicenter study. In: Laryngoscope. 2018 ; Vol. 128, No. 1. pp. 184-188.
@article{ce4bcd1162bc48aab4f020dadf59d0ca,
title = "Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus: A prospective, placebo-controlled, multicenter study",
abstract = "Objective: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin. Study Design: A prospective, randomized, placebo-controlled, double-blinded, multicenter study. Methods: Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization. Intratympanic injections were administered four times over 2 weeks. At 4 weeks after initial injection, we analyzed the improvement rates of tinnitus using the tinnitus handicap Inventory (THI) and visual analogue scale (VAS) for loudness, awareness, and annoyance. We defined improvement as the reduction of more than 7 points or of more than 20{\%} in the final THI score compared to the initial THI score. Results: The initial mean hearing thresholds and VAS and THI scores of the two groups did not differ significantly. At 4 weeks after initial injection, the mean VAS and THI scores of both groups had significantly reduced. However, the improvement rate did not differ significantly between the groups (ITDI, 51.9{\%}; ITNI, 59.3{\%}). Conclusion: The results indicate that ITDI might not be more effective than ITNI for the treatment of acute unilateral tinnitus. Therefore, ITDI should not be considered as the main treatment for patients presenting with acute tinnitus as the primary symptom. Level of Evidence: 1b. Laryngoscope, 128:184–188, 2018.",
author = "Lee, {Hyun Jin} and Kim, {Min Beom} and Yoo, {Shin Young} and Park, {Shi Nae} and Nam, {Eui Cheol} and Moon, {In Seok} and Lee, {Ho Ki}",
year = "2018",
month = "1",
doi = "10.1002/lary.26541",
language = "English",
volume = "128",
pages = "184--188",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus : A prospective, placebo-controlled, multicenter study. / Lee, Hyun Jin; Kim, Min Beom; Yoo, Shin Young; Park, Shi Nae; Nam, Eui Cheol; Moon, In Seok; Lee, Ho Ki.

In: Laryngoscope, Vol. 128, No. 1, 01.2018, p. 184-188.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus

T2 - A prospective, placebo-controlled, multicenter study

AU - Lee, Hyun Jin

AU - Kim, Min Beom

AU - Yoo, Shin Young

AU - Park, Shi Nae

AU - Nam, Eui Cheol

AU - Moon, In Seok

AU - Lee, Ho Ki

PY - 2018/1

Y1 - 2018/1

N2 - Objective: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin. Study Design: A prospective, randomized, placebo-controlled, double-blinded, multicenter study. Methods: Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization. Intratympanic injections were administered four times over 2 weeks. At 4 weeks after initial injection, we analyzed the improvement rates of tinnitus using the tinnitus handicap Inventory (THI) and visual analogue scale (VAS) for loudness, awareness, and annoyance. We defined improvement as the reduction of more than 7 points or of more than 20% in the final THI score compared to the initial THI score. Results: The initial mean hearing thresholds and VAS and THI scores of the two groups did not differ significantly. At 4 weeks after initial injection, the mean VAS and THI scores of both groups had significantly reduced. However, the improvement rate did not differ significantly between the groups (ITDI, 51.9%; ITNI, 59.3%). Conclusion: The results indicate that ITDI might not be more effective than ITNI for the treatment of acute unilateral tinnitus. Therefore, ITDI should not be considered as the main treatment for patients presenting with acute tinnitus as the primary symptom. Level of Evidence: 1b. Laryngoscope, 128:184–188, 2018.

AB - Objective: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin. Study Design: A prospective, randomized, placebo-controlled, double-blinded, multicenter study. Methods: Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization. Intratympanic injections were administered four times over 2 weeks. At 4 weeks after initial injection, we analyzed the improvement rates of tinnitus using the tinnitus handicap Inventory (THI) and visual analogue scale (VAS) for loudness, awareness, and annoyance. We defined improvement as the reduction of more than 7 points or of more than 20% in the final THI score compared to the initial THI score. Results: The initial mean hearing thresholds and VAS and THI scores of the two groups did not differ significantly. At 4 weeks after initial injection, the mean VAS and THI scores of both groups had significantly reduced. However, the improvement rate did not differ significantly between the groups (ITDI, 51.9%; ITNI, 59.3%). Conclusion: The results indicate that ITDI might not be more effective than ITNI for the treatment of acute unilateral tinnitus. Therefore, ITDI should not be considered as the main treatment for patients presenting with acute tinnitus as the primary symptom. Level of Evidence: 1b. Laryngoscope, 128:184–188, 2018.

UR - http://www.scopus.com/inward/record.url?scp=85013377386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013377386&partnerID=8YFLogxK

U2 - 10.1002/lary.26541

DO - 10.1002/lary.26541

M3 - Article

C2 - 28224644

AN - SCOPUS:85013377386

VL - 128

SP - 184

EP - 188

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 1

ER -