Clinical efficacy and tolerance of 1% nadifloxacin cream in the treatment of mild to moderate acne vulgaris in South Korea

Won Jun Choi, Kwang Joong Kim, Nack In Kim, Young Chul Kye, Dae Hun Suh, Joo Heung Lee, Myeung Nam Kim, Eun So Lee, Ju Hee Lee, Young Suck Ro

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2 Citations (Scopus)

Abstract

Background: Antimicrobials have been a mainstay of inflammatory acne treatment for more than 30 years. However, antibiotic-resistant propionibacteria had been isolated with increased frequency, and associated with failure to respond to antibiotic therapy. Objective: The aim of this study was to investigate the clinical efficacy and tolerance of 1% nadifloxacin cream. Methods: In the final analysis, 197 patients with mild to moderate facial acne vulgaris were enrolled. The patients were instructed to apply 1% nadifloxacin cream twice daily to the affected skin after washing the face. Following 2 and 4 weeks of treatment, patients were observed for clinical response: number of the acne lesions, Korea acne grading system (KAGS), global improvement, and occurrence of adverse reactions. Results: During 4 weeks of treatment, nadifloxacin caused significant reduction in the number of inflamed papulo-pustular lesions and open/closed comedones. In addition, significant reduction of KAGS was observed. About 96% of patients showed clinical improvement in the overall evaluation of the therapeutic effect by physicians. All reported adverse events were mild. Conclusion: This study shows that 1% nadifloxacin cream can be an effective and safe treatment for mild to moderate acne vulgaris.

Original languageEnglish
Pages (from-to)665-671
Number of pages7
JournalKorean Journal of Dermatology
Volume48
Issue number8
Publication statusPublished - 2010 Aug

All Science Journal Classification (ASJC) codes

  • Dermatology

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    Choi, W. J., Kim, K. J., Kim, N. I., Kye, Y. C., Suh, D. H., Lee, J. H., Kim, M. N., Lee, E. S., Lee, J. H., & Ro, Y. S. (2010). Clinical efficacy and tolerance of 1% nadifloxacin cream in the treatment of mild to moderate acne vulgaris in South Korea. Korean Journal of Dermatology, 48(8), 665-671.