Clinical factors associated with acquisition of resistance to levofloxacin in Stenotrophomonas maltophilia

Ji Hyeon Baek, Chang Oh Kim, Su Jin Jeong, Nam Soo Ku, Sang Hoon Han, JunYong Choi, DongEun Yong, Young Goo Song, Kyungwon Lee, June Myung Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Fluoroquinolones, rapidly gaining prominence in treatment of Stenotrophomonas maltophilia (SMP), are noted for their potency and tolerability. However, SMP may rapidly acquire resistance to fluoroquinolones. We evaluated associations of clinical factors with acquisition of levofloxacin resistance (LFr) in SMP. Materials and Methods: Our retrospective cohort study was based on patient data collected between January 2008 and June 2010. Through screening of 1275 patients, we identified 122 patients with data for SMP antibiotic susceptibility testing in ≥3 serial SMP isolates. Results: We assigned the 122 patients to either the SS group (n=54) in which levofloxacin susceptibility was maintained or the SR group (n=31) in which susceptible SMP acquired resistance. In multivariate regression analysis, exposure to levofloxacin for more than 3 weeks [odds ratio (OR) 15.39, 95% confidential interval (CI) 3.08--76.93, p=0.001] and co-infection or co-colonization with Klebsiella pneumoniae resistant to levofloxacin (OR 4.85, 95% CI 1.16--20.24, p=0.030) were independently associated with LFr acquisition in SMP. Conclusion: Acquisition of LFr during serial sampling of SMP was related to the levofloxacin exposure.

Original languageEnglish
Pages (from-to)987-993
Number of pages7
JournalYonsei medical journal
Volume55
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Stenotrophomonas maltophilia
Levofloxacin
Fluoroquinolones
Odds Ratio
Klebsiella pneumoniae
Coinfection
Cohort Studies
Multivariate Analysis
Retrospective Studies
Regression Analysis
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Baek, Ji Hyeon ; Kim, Chang Oh ; Jeong, Su Jin ; Ku, Nam Soo ; Han, Sang Hoon ; Choi, JunYong ; Yong, DongEun ; Song, Young Goo ; Lee, Kyungwon ; Kim, June Myung. / Clinical factors associated with acquisition of resistance to levofloxacin in Stenotrophomonas maltophilia. In: Yonsei medical journal. 2014 ; Vol. 55, No. 4. pp. 987-993.
@article{1f9e6ae4763a48fcb7dd1a21f1dee2fd,
title = "Clinical factors associated with acquisition of resistance to levofloxacin in Stenotrophomonas maltophilia",
abstract = "Purpose: Fluoroquinolones, rapidly gaining prominence in treatment of Stenotrophomonas maltophilia (SMP), are noted for their potency and tolerability. However, SMP may rapidly acquire resistance to fluoroquinolones. We evaluated associations of clinical factors with acquisition of levofloxacin resistance (LFr) in SMP. Materials and Methods: Our retrospective cohort study was based on patient data collected between January 2008 and June 2010. Through screening of 1275 patients, we identified 122 patients with data for SMP antibiotic susceptibility testing in ≥3 serial SMP isolates. Results: We assigned the 122 patients to either the SS group (n=54) in which levofloxacin susceptibility was maintained or the SR group (n=31) in which susceptible SMP acquired resistance. In multivariate regression analysis, exposure to levofloxacin for more than 3 weeks [odds ratio (OR) 15.39, 95{\%} confidential interval (CI) 3.08--76.93, p=0.001] and co-infection or co-colonization with Klebsiella pneumoniae resistant to levofloxacin (OR 4.85, 95{\%} CI 1.16--20.24, p=0.030) were independently associated with LFr acquisition in SMP. Conclusion: Acquisition of LFr during serial sampling of SMP was related to the levofloxacin exposure.",
author = "Baek, {Ji Hyeon} and Kim, {Chang Oh} and Jeong, {Su Jin} and Ku, {Nam Soo} and Han, {Sang Hoon} and JunYong Choi and DongEun Yong and Song, {Young Goo} and Kyungwon Lee and Kim, {June Myung}",
year = "2014",
month = "1",
day = "1",
doi = "10.3349/ymj.2014.55.4.987",
language = "English",
volume = "55",
pages = "987--993",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "4",

}

Clinical factors associated with acquisition of resistance to levofloxacin in Stenotrophomonas maltophilia. / Baek, Ji Hyeon; Kim, Chang Oh; Jeong, Su Jin; Ku, Nam Soo; Han, Sang Hoon; Choi, JunYong; Yong, DongEun; Song, Young Goo; Lee, Kyungwon; Kim, June Myung.

In: Yonsei medical journal, Vol. 55, No. 4, 01.01.2014, p. 987-993.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical factors associated with acquisition of resistance to levofloxacin in Stenotrophomonas maltophilia

AU - Baek, Ji Hyeon

AU - Kim, Chang Oh

AU - Jeong, Su Jin

AU - Ku, Nam Soo

AU - Han, Sang Hoon

AU - Choi, JunYong

AU - Yong, DongEun

AU - Song, Young Goo

AU - Lee, Kyungwon

AU - Kim, June Myung

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: Fluoroquinolones, rapidly gaining prominence in treatment of Stenotrophomonas maltophilia (SMP), are noted for their potency and tolerability. However, SMP may rapidly acquire resistance to fluoroquinolones. We evaluated associations of clinical factors with acquisition of levofloxacin resistance (LFr) in SMP. Materials and Methods: Our retrospective cohort study was based on patient data collected between January 2008 and June 2010. Through screening of 1275 patients, we identified 122 patients with data for SMP antibiotic susceptibility testing in ≥3 serial SMP isolates. Results: We assigned the 122 patients to either the SS group (n=54) in which levofloxacin susceptibility was maintained or the SR group (n=31) in which susceptible SMP acquired resistance. In multivariate regression analysis, exposure to levofloxacin for more than 3 weeks [odds ratio (OR) 15.39, 95% confidential interval (CI) 3.08--76.93, p=0.001] and co-infection or co-colonization with Klebsiella pneumoniae resistant to levofloxacin (OR 4.85, 95% CI 1.16--20.24, p=0.030) were independently associated with LFr acquisition in SMP. Conclusion: Acquisition of LFr during serial sampling of SMP was related to the levofloxacin exposure.

AB - Purpose: Fluoroquinolones, rapidly gaining prominence in treatment of Stenotrophomonas maltophilia (SMP), are noted for their potency and tolerability. However, SMP may rapidly acquire resistance to fluoroquinolones. We evaluated associations of clinical factors with acquisition of levofloxacin resistance (LFr) in SMP. Materials and Methods: Our retrospective cohort study was based on patient data collected between January 2008 and June 2010. Through screening of 1275 patients, we identified 122 patients with data for SMP antibiotic susceptibility testing in ≥3 serial SMP isolates. Results: We assigned the 122 patients to either the SS group (n=54) in which levofloxacin susceptibility was maintained or the SR group (n=31) in which susceptible SMP acquired resistance. In multivariate regression analysis, exposure to levofloxacin for more than 3 weeks [odds ratio (OR) 15.39, 95% confidential interval (CI) 3.08--76.93, p=0.001] and co-infection or co-colonization with Klebsiella pneumoniae resistant to levofloxacin (OR 4.85, 95% CI 1.16--20.24, p=0.030) were independently associated with LFr acquisition in SMP. Conclusion: Acquisition of LFr during serial sampling of SMP was related to the levofloxacin exposure.

UR - http://www.scopus.com/inward/record.url?scp=84903123790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903123790&partnerID=8YFLogxK

U2 - 10.3349/ymj.2014.55.4.987

DO - 10.3349/ymj.2014.55.4.987

M3 - Article

VL - 55

SP - 987

EP - 993

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 4

ER -