Clinical factors associated with carotid plaque and intima-medial thickness in HIV-infected patients

Su Jin Jeong, Hye Won Kim, Nam Su Ku, Sang Hoon Han, Chang Oh Kim, JunYong Choi, Young Goo Song, June Myung Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: HIV-infected patients are at increased risk for cardiovascular disease, which may be mediated in part by inflammation. This study aimed to evaluate the risk factors of carotid plaque, and clinical factors associated with carotid atherosclerosis measured by carotid intima-medial thickness (cIMT) in HIV patients. Materials and Methods: Clinical and cardiometabolic factors as well as cIMT were prospectively measured in 145 HIV-infected participants who had received combined antiretroviral therapy for ≥6 months. The mean value of the bilateral average cIMT level was used as Mean-IMT in the analysis, and the greatest value among the measured cIMT levels was used as Max-IMT. Results: Among 145 patients, 34 (23.4%) had carotid plaque. Multivariate logistic regression analysis revealed three independent risk factors of carotid plaque: old age [odds ratio (OR) 6.16, 95% confidence interval (CI) 1.09-34.88; p=0.040], hypertension (OR 12.62, 95% CI 1.72-92.49; p=0.013) and higher low-density lipoprotein cholesterol (LDL-C) (OR 1.08, 95% CI 1.01-1.16; p=0.039). Levels of estimated glomerular filtration rate were inversely associated with Mean-IMT (r=-0.379, p<0.001) and Max-IMT (r=-0.389, p<0.001). Stepwise multivariate regression analyses revealed that age, total cholesterol and fasting glucose were positively correlated with cIMT, independent of other risk factors. Conclusion: The presence of hypertension, old age and a higher level of LDL-C were independent risk factors of carotid plaque among HIV-infected subjects.

Original languageEnglish
Pages (from-to)990-998
Number of pages9
JournalYonsei medical journal
Volume54
Issue number4
DOIs
Publication statusPublished - 2013 Jul 1

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HIV
Odds Ratio
Confidence Intervals
LDL Cholesterol
Regression Analysis
Hypertension
Carotid Artery Diseases
Glomerular Filtration Rate
HDL Cholesterol
Fasting
Cardiovascular Diseases
Multivariate Analysis
Logistic Models
Cholesterol
Inflammation
Glucose
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jeong, Su Jin ; Kim, Hye Won ; Ku, Nam Su ; Han, Sang Hoon ; Kim, Chang Oh ; Choi, JunYong ; Song, Young Goo ; Kim, June Myung. / Clinical factors associated with carotid plaque and intima-medial thickness in HIV-infected patients. In: Yonsei medical journal. 2013 ; Vol. 54, No. 4. pp. 990-998.
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abstract = "Purpose: HIV-infected patients are at increased risk for cardiovascular disease, which may be mediated in part by inflammation. This study aimed to evaluate the risk factors of carotid plaque, and clinical factors associated with carotid atherosclerosis measured by carotid intima-medial thickness (cIMT) in HIV patients. Materials and Methods: Clinical and cardiometabolic factors as well as cIMT were prospectively measured in 145 HIV-infected participants who had received combined antiretroviral therapy for ≥6 months. The mean value of the bilateral average cIMT level was used as Mean-IMT in the analysis, and the greatest value among the measured cIMT levels was used as Max-IMT. Results: Among 145 patients, 34 (23.4{\%}) had carotid plaque. Multivariate logistic regression analysis revealed three independent risk factors of carotid plaque: old age [odds ratio (OR) 6.16, 95{\%} confidence interval (CI) 1.09-34.88; p=0.040], hypertension (OR 12.62, 95{\%} CI 1.72-92.49; p=0.013) and higher low-density lipoprotein cholesterol (LDL-C) (OR 1.08, 95{\%} CI 1.01-1.16; p=0.039). Levels of estimated glomerular filtration rate were inversely associated with Mean-IMT (r=-0.379, p<0.001) and Max-IMT (r=-0.389, p<0.001). Stepwise multivariate regression analyses revealed that age, total cholesterol and fasting glucose were positively correlated with cIMT, independent of other risk factors. Conclusion: The presence of hypertension, old age and a higher level of LDL-C were independent risk factors of carotid plaque among HIV-infected subjects.",
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Clinical factors associated with carotid plaque and intima-medial thickness in HIV-infected patients. / Jeong, Su Jin; Kim, Hye Won; Ku, Nam Su; Han, Sang Hoon; Kim, Chang Oh; Choi, JunYong; Song, Young Goo; Kim, June Myung.

In: Yonsei medical journal, Vol. 54, No. 4, 01.07.2013, p. 990-998.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical factors associated with carotid plaque and intima-medial thickness in HIV-infected patients

AU - Jeong, Su Jin

AU - Kim, Hye Won

AU - Ku, Nam Su

AU - Han, Sang Hoon

AU - Kim, Chang Oh

AU - Choi, JunYong

AU - Song, Young Goo

AU - Kim, June Myung

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Purpose: HIV-infected patients are at increased risk for cardiovascular disease, which may be mediated in part by inflammation. This study aimed to evaluate the risk factors of carotid plaque, and clinical factors associated with carotid atherosclerosis measured by carotid intima-medial thickness (cIMT) in HIV patients. Materials and Methods: Clinical and cardiometabolic factors as well as cIMT were prospectively measured in 145 HIV-infected participants who had received combined antiretroviral therapy for ≥6 months. The mean value of the bilateral average cIMT level was used as Mean-IMT in the analysis, and the greatest value among the measured cIMT levels was used as Max-IMT. Results: Among 145 patients, 34 (23.4%) had carotid plaque. Multivariate logistic regression analysis revealed three independent risk factors of carotid plaque: old age [odds ratio (OR) 6.16, 95% confidence interval (CI) 1.09-34.88; p=0.040], hypertension (OR 12.62, 95% CI 1.72-92.49; p=0.013) and higher low-density lipoprotein cholesterol (LDL-C) (OR 1.08, 95% CI 1.01-1.16; p=0.039). Levels of estimated glomerular filtration rate were inversely associated with Mean-IMT (r=-0.379, p<0.001) and Max-IMT (r=-0.389, p<0.001). Stepwise multivariate regression analyses revealed that age, total cholesterol and fasting glucose were positively correlated with cIMT, independent of other risk factors. Conclusion: The presence of hypertension, old age and a higher level of LDL-C were independent risk factors of carotid plaque among HIV-infected subjects.

AB - Purpose: HIV-infected patients are at increased risk for cardiovascular disease, which may be mediated in part by inflammation. This study aimed to evaluate the risk factors of carotid plaque, and clinical factors associated with carotid atherosclerosis measured by carotid intima-medial thickness (cIMT) in HIV patients. Materials and Methods: Clinical and cardiometabolic factors as well as cIMT were prospectively measured in 145 HIV-infected participants who had received combined antiretroviral therapy for ≥6 months. The mean value of the bilateral average cIMT level was used as Mean-IMT in the analysis, and the greatest value among the measured cIMT levels was used as Max-IMT. Results: Among 145 patients, 34 (23.4%) had carotid plaque. Multivariate logistic regression analysis revealed three independent risk factors of carotid plaque: old age [odds ratio (OR) 6.16, 95% confidence interval (CI) 1.09-34.88; p=0.040], hypertension (OR 12.62, 95% CI 1.72-92.49; p=0.013) and higher low-density lipoprotein cholesterol (LDL-C) (OR 1.08, 95% CI 1.01-1.16; p=0.039). Levels of estimated glomerular filtration rate were inversely associated with Mean-IMT (r=-0.379, p<0.001) and Max-IMT (r=-0.389, p<0.001). Stepwise multivariate regression analyses revealed that age, total cholesterol and fasting glucose were positively correlated with cIMT, independent of other risk factors. Conclusion: The presence of hypertension, old age and a higher level of LDL-C were independent risk factors of carotid plaque among HIV-infected subjects.

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