Clinical features and outcomes of focal segmental glomerulosclerosis pathologic variants in Korean adult patients

Young Eun Kwon, SeungHyeok Han, Jeong Hae Kie, Seong Yeong An, Yung Ly Kim, Kyoung Sook Park, Ki Heon Nam, Ah Young Leem, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Ea Wha Kang, Shin-Wook Kang, Kyu Hun Choi, Beom Jin Lim, Hyeon Joo Jeong, TaeHyun Yoo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Many studies have shown that clinical characteristics and outcomes differ depending on pathologic variants of focal segmental glomerulosclerosis (FSGS). However, these are not well defined in Asian populations. Methods. This retrospective study evaluated clinical features and outcomes of pathologic FSGS variants in 111 adult patients between January 2004 and December 2012. Primary outcome was the composite of doubling of baseline serum creatinine concentrations (D-SCr) or onset of end-stage renal disease (ESRD). Secondary outcome included complete (CR) or partial remission (PR). Results: There were 70 (63.1%), 20 (18.0%), 17 (15.3%), 3 (2.7%), and 1 (0.9%) patients with not-otherwise specified (NOS), tip, perihilar, cellular, and collapsing variants, respectively. At presentation, nephrotic-range proteinuria occurred more commonly in tip lesion than in other variants. The overall 5-year renal survival rate was 76.8%. During a median follow-up of 34.5 months, only 1 (5.0%) patient with a tip lesion reached the composite end point compared to 2 (11.8%) and 12 (17.1%) patients in perihilar and NOS variants, but this difference was not statistically significant in an adjusted Cox model. However, tip lesion was associated with a significantly increased probability of achieving CR (P = 0.044). Conclusion: Similar to other populations, Korean adult patients with FSGS have distinct clinical features with the exception of a rare frequency of cellular and collapsing variants. Although pathologic variants were not associated with overall outcome, the tip variant exhibited favorable outcome in terms of achieving remission. Further studies are required to delineate long-term outcome and response to treatment of the pathologic variants.

Original languageEnglish
Article number52
JournalBMC Nephrology
Volume15
Issue number1
DOIs
Publication statusPublished - 2014 Mar 25

Fingerprint

Focal Segmental Glomerulosclerosis
Proteinuria
Proportional Hazards Models
Population
Chronic Kidney Failure
Creatinine
Survival Rate
Retrospective Studies
Kidney
Serum

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Kwon, Young Eun ; Han, SeungHyeok ; Kie, Jeong Hae ; An, Seong Yeong ; Kim, Yung Ly ; Park, Kyoung Sook ; Nam, Ki Heon ; Leem, Ah Young ; Oh, Hyung Jung ; Park, Jung Tak ; Chang, Tae Ik ; Kang, Ea Wha ; Kang, Shin-Wook ; Choi, Kyu Hun ; Lim, Beom Jin ; Jeong, Hyeon Joo ; Yoo, TaeHyun. / Clinical features and outcomes of focal segmental glomerulosclerosis pathologic variants in Korean adult patients. In: BMC Nephrology. 2014 ; Vol. 15, No. 1.
@article{1410cd3ef20340a7957031a35676d278,
title = "Clinical features and outcomes of focal segmental glomerulosclerosis pathologic variants in Korean adult patients",
abstract = "Background: Many studies have shown that clinical characteristics and outcomes differ depending on pathologic variants of focal segmental glomerulosclerosis (FSGS). However, these are not well defined in Asian populations. Methods. This retrospective study evaluated clinical features and outcomes of pathologic FSGS variants in 111 adult patients between January 2004 and December 2012. Primary outcome was the composite of doubling of baseline serum creatinine concentrations (D-SCr) or onset of end-stage renal disease (ESRD). Secondary outcome included complete (CR) or partial remission (PR). Results: There were 70 (63.1{\%}), 20 (18.0{\%}), 17 (15.3{\%}), 3 (2.7{\%}), and 1 (0.9{\%}) patients with not-otherwise specified (NOS), tip, perihilar, cellular, and collapsing variants, respectively. At presentation, nephrotic-range proteinuria occurred more commonly in tip lesion than in other variants. The overall 5-year renal survival rate was 76.8{\%}. During a median follow-up of 34.5 months, only 1 (5.0{\%}) patient with a tip lesion reached the composite end point compared to 2 (11.8{\%}) and 12 (17.1{\%}) patients in perihilar and NOS variants, but this difference was not statistically significant in an adjusted Cox model. However, tip lesion was associated with a significantly increased probability of achieving CR (P = 0.044). Conclusion: Similar to other populations, Korean adult patients with FSGS have distinct clinical features with the exception of a rare frequency of cellular and collapsing variants. Although pathologic variants were not associated with overall outcome, the tip variant exhibited favorable outcome in terms of achieving remission. Further studies are required to delineate long-term outcome and response to treatment of the pathologic variants.",
author = "Kwon, {Young Eun} and SeungHyeok Han and Kie, {Jeong Hae} and An, {Seong Yeong} and Kim, {Yung Ly} and Park, {Kyoung Sook} and Nam, {Ki Heon} and Leem, {Ah Young} and Oh, {Hyung Jung} and Park, {Jung Tak} and Chang, {Tae Ik} and Kang, {Ea Wha} and Shin-Wook Kang and Choi, {Kyu Hun} and Lim, {Beom Jin} and Jeong, {Hyeon Joo} and TaeHyun Yoo",
year = "2014",
month = "3",
day = "25",
doi = "10.1186/1471-2369-15-52",
language = "English",
volume = "15",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BioMed Central",
number = "1",

}

Kwon, YE, Han, S, Kie, JH, An, SY, Kim, YL, Park, KS, Nam, KH, Leem, AY, Oh, HJ, Park, JT, Chang, TI, Kang, EW, Kang, S-W, Choi, KH, Lim, BJ, Jeong, HJ & Yoo, T 2014, 'Clinical features and outcomes of focal segmental glomerulosclerosis pathologic variants in Korean adult patients', BMC Nephrology, vol. 15, no. 1, 52. https://doi.org/10.1186/1471-2369-15-52

Clinical features and outcomes of focal segmental glomerulosclerosis pathologic variants in Korean adult patients. / Kwon, Young Eun; Han, SeungHyeok; Kie, Jeong Hae; An, Seong Yeong; Kim, Yung Ly; Park, Kyoung Sook; Nam, Ki Heon; Leem, Ah Young; Oh, Hyung Jung; Park, Jung Tak; Chang, Tae Ik; Kang, Ea Wha; Kang, Shin-Wook; Choi, Kyu Hun; Lim, Beom Jin; Jeong, Hyeon Joo; Yoo, TaeHyun.

In: BMC Nephrology, Vol. 15, No. 1, 52, 25.03.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical features and outcomes of focal segmental glomerulosclerosis pathologic variants in Korean adult patients

AU - Kwon, Young Eun

AU - Han, SeungHyeok

AU - Kie, Jeong Hae

AU - An, Seong Yeong

AU - Kim, Yung Ly

AU - Park, Kyoung Sook

AU - Nam, Ki Heon

AU - Leem, Ah Young

AU - Oh, Hyung Jung

AU - Park, Jung Tak

AU - Chang, Tae Ik

AU - Kang, Ea Wha

AU - Kang, Shin-Wook

AU - Choi, Kyu Hun

AU - Lim, Beom Jin

AU - Jeong, Hyeon Joo

AU - Yoo, TaeHyun

PY - 2014/3/25

Y1 - 2014/3/25

N2 - Background: Many studies have shown that clinical characteristics and outcomes differ depending on pathologic variants of focal segmental glomerulosclerosis (FSGS). However, these are not well defined in Asian populations. Methods. This retrospective study evaluated clinical features and outcomes of pathologic FSGS variants in 111 adult patients between January 2004 and December 2012. Primary outcome was the composite of doubling of baseline serum creatinine concentrations (D-SCr) or onset of end-stage renal disease (ESRD). Secondary outcome included complete (CR) or partial remission (PR). Results: There were 70 (63.1%), 20 (18.0%), 17 (15.3%), 3 (2.7%), and 1 (0.9%) patients with not-otherwise specified (NOS), tip, perihilar, cellular, and collapsing variants, respectively. At presentation, nephrotic-range proteinuria occurred more commonly in tip lesion than in other variants. The overall 5-year renal survival rate was 76.8%. During a median follow-up of 34.5 months, only 1 (5.0%) patient with a tip lesion reached the composite end point compared to 2 (11.8%) and 12 (17.1%) patients in perihilar and NOS variants, but this difference was not statistically significant in an adjusted Cox model. However, tip lesion was associated with a significantly increased probability of achieving CR (P = 0.044). Conclusion: Similar to other populations, Korean adult patients with FSGS have distinct clinical features with the exception of a rare frequency of cellular and collapsing variants. Although pathologic variants were not associated with overall outcome, the tip variant exhibited favorable outcome in terms of achieving remission. Further studies are required to delineate long-term outcome and response to treatment of the pathologic variants.

AB - Background: Many studies have shown that clinical characteristics and outcomes differ depending on pathologic variants of focal segmental glomerulosclerosis (FSGS). However, these are not well defined in Asian populations. Methods. This retrospective study evaluated clinical features and outcomes of pathologic FSGS variants in 111 adult patients between January 2004 and December 2012. Primary outcome was the composite of doubling of baseline serum creatinine concentrations (D-SCr) or onset of end-stage renal disease (ESRD). Secondary outcome included complete (CR) or partial remission (PR). Results: There were 70 (63.1%), 20 (18.0%), 17 (15.3%), 3 (2.7%), and 1 (0.9%) patients with not-otherwise specified (NOS), tip, perihilar, cellular, and collapsing variants, respectively. At presentation, nephrotic-range proteinuria occurred more commonly in tip lesion than in other variants. The overall 5-year renal survival rate was 76.8%. During a median follow-up of 34.5 months, only 1 (5.0%) patient with a tip lesion reached the composite end point compared to 2 (11.8%) and 12 (17.1%) patients in perihilar and NOS variants, but this difference was not statistically significant in an adjusted Cox model. However, tip lesion was associated with a significantly increased probability of achieving CR (P = 0.044). Conclusion: Similar to other populations, Korean adult patients with FSGS have distinct clinical features with the exception of a rare frequency of cellular and collapsing variants. Although pathologic variants were not associated with overall outcome, the tip variant exhibited favorable outcome in terms of achieving remission. Further studies are required to delineate long-term outcome and response to treatment of the pathologic variants.

UR - http://www.scopus.com/inward/record.url?scp=84898482751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898482751&partnerID=8YFLogxK

U2 - 10.1186/1471-2369-15-52

DO - 10.1186/1471-2369-15-52

M3 - Article

C2 - 24666814

AN - SCOPUS:84898482751

VL - 15

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

M1 - 52

ER -