Clinical features and prognosis of hepatocellular carcinoma in Mongolia: A multicentre study

Oidov Baatarkhuu, doyoung kim, Pagbajabyn Nymadawa, Seungup Kim, KwangHyub Han, Jazag Amarsanaa, Dagvasumberel Gonchigsuren, Ravjir Sanduijav, Zundui Lkhagvasuren, Naran Khorolsuren, Ravjir Oyungerel, SangHoon Ahn

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Abstract

Purpose Hepatocellular carcinoma (HCC) is the most common cancer in Mongolia. We aimed to investigate the clinical features, therapeutic modalities, overall survival and prognostic factors for Mongolian patients with HCC. Method One hundred ninety-five patients with HCC were consecutively enroled in our study. Results The mean age was 61.7 years. The most common etiology for HCC was HCV infection (n = 89, 45.6%), followed by HBV infection (n = 67, 34.4%). The mean tumor diameter was 6.0 ± 2.6 cm. Only 29 (14.9%) patients had a single lesion, while 39 (20.2%) had[3 lesions. Extrahepatic metastasis to lung (n = 23), bone (n = 10) and lymph node (n = 3) were detected in 36 (18.5%) patients. Most patients had advanced HCC-88 (45.1%) in stage III and 57 (29.2%) in stage IV. Surgical resection was performed in 27 (13.8%) patients,RFAin 23 (11.8%) andTACEin 107 (54.9%).When all the patients were categorized as 'treated' (n = 156) and 'not treated' (n = 39), the 3-year survival was significantly lower in the 'not treated' group than in the 'treated' group (11 vs. 0%, P<0.001). Tumor diameter (≥3 cm vs. C3 cm), extrahepatic metastasis, TNM stage (I/II vs. III/IV) and treatment (or supportive care) were selected as independent predictors for survival. Conclusions High proportion of patients with HCC in Mongolia is diagnosed at an advanced stage and survival of these patients is lower compared to other countries. A surveillance system and referral policy for high-risk groups should be urgently established and implemented in Mongolia.

Original languageEnglish
Pages (from-to)763-769
Number of pages7
JournalHepatology International
Volume6
Issue number4
DOIs
Publication statusPublished - 2012 Oct 1

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Mongolia
Multicenter Studies
Hepatocellular Carcinoma
Survival
Neoplasm Metastasis
Neoplasms
Infection
Referral and Consultation
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Baatarkhuu, Oidov ; kim, doyoung ; Nymadawa, Pagbajabyn ; Kim, Seungup ; Han, KwangHyub ; Amarsanaa, Jazag ; Gonchigsuren, Dagvasumberel ; Sanduijav, Ravjir ; Lkhagvasuren, Zundui ; Khorolsuren, Naran ; Oyungerel, Ravjir ; Ahn, SangHoon. / Clinical features and prognosis of hepatocellular carcinoma in Mongolia : A multicentre study. In: Hepatology International. 2012 ; Vol. 6, No. 4. pp. 763-769.
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title = "Clinical features and prognosis of hepatocellular carcinoma in Mongolia: A multicentre study",
abstract = "Purpose Hepatocellular carcinoma (HCC) is the most common cancer in Mongolia. We aimed to investigate the clinical features, therapeutic modalities, overall survival and prognostic factors for Mongolian patients with HCC. Method One hundred ninety-five patients with HCC were consecutively enroled in our study. Results The mean age was 61.7 years. The most common etiology for HCC was HCV infection (n = 89, 45.6{\%}), followed by HBV infection (n = 67, 34.4{\%}). The mean tumor diameter was 6.0 ± 2.6 cm. Only 29 (14.9{\%}) patients had a single lesion, while 39 (20.2{\%}) had[3 lesions. Extrahepatic metastasis to lung (n = 23), bone (n = 10) and lymph node (n = 3) were detected in 36 (18.5{\%}) patients. Most patients had advanced HCC-88 (45.1{\%}) in stage III and 57 (29.2{\%}) in stage IV. Surgical resection was performed in 27 (13.8{\%}) patients,RFAin 23 (11.8{\%}) andTACEin 107 (54.9{\%}).When all the patients were categorized as 'treated' (n = 156) and 'not treated' (n = 39), the 3-year survival was significantly lower in the 'not treated' group than in the 'treated' group (11 vs. 0{\%}, P<0.001). Tumor diameter (≥3 cm vs. C3 cm), extrahepatic metastasis, TNM stage (I/II vs. III/IV) and treatment (or supportive care) were selected as independent predictors for survival. Conclusions High proportion of patients with HCC in Mongolia is diagnosed at an advanced stage and survival of these patients is lower compared to other countries. A surveillance system and referral policy for high-risk groups should be urgently established and implemented in Mongolia.",
author = "Oidov Baatarkhuu and doyoung kim and Pagbajabyn Nymadawa and Seungup Kim and KwangHyub Han and Jazag Amarsanaa and Dagvasumberel Gonchigsuren and Ravjir Sanduijav and Zundui Lkhagvasuren and Naran Khorolsuren and Ravjir Oyungerel and SangHoon Ahn",
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Baatarkhuu, O, kim, D, Nymadawa, P, Kim, S, Han, K, Amarsanaa, J, Gonchigsuren, D, Sanduijav, R, Lkhagvasuren, Z, Khorolsuren, N, Oyungerel, R & Ahn, S 2012, 'Clinical features and prognosis of hepatocellular carcinoma in Mongolia: A multicentre study', Hepatology International, vol. 6, no. 4, pp. 763-769. https://doi.org/10.1007/s12072-011-9325-4

Clinical features and prognosis of hepatocellular carcinoma in Mongolia : A multicentre study. / Baatarkhuu, Oidov; kim, doyoung; Nymadawa, Pagbajabyn; Kim, Seungup; Han, KwangHyub; Amarsanaa, Jazag; Gonchigsuren, Dagvasumberel; Sanduijav, Ravjir; Lkhagvasuren, Zundui; Khorolsuren, Naran; Oyungerel, Ravjir; Ahn, SangHoon.

In: Hepatology International, Vol. 6, No. 4, 01.10.2012, p. 763-769.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical features and prognosis of hepatocellular carcinoma in Mongolia

T2 - A multicentre study

AU - Baatarkhuu, Oidov

AU - kim, doyoung

AU - Nymadawa, Pagbajabyn

AU - Kim, Seungup

AU - Han, KwangHyub

AU - Amarsanaa, Jazag

AU - Gonchigsuren, Dagvasumberel

AU - Sanduijav, Ravjir

AU - Lkhagvasuren, Zundui

AU - Khorolsuren, Naran

AU - Oyungerel, Ravjir

AU - Ahn, SangHoon

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Purpose Hepatocellular carcinoma (HCC) is the most common cancer in Mongolia. We aimed to investigate the clinical features, therapeutic modalities, overall survival and prognostic factors for Mongolian patients with HCC. Method One hundred ninety-five patients with HCC were consecutively enroled in our study. Results The mean age was 61.7 years. The most common etiology for HCC was HCV infection (n = 89, 45.6%), followed by HBV infection (n = 67, 34.4%). The mean tumor diameter was 6.0 ± 2.6 cm. Only 29 (14.9%) patients had a single lesion, while 39 (20.2%) had[3 lesions. Extrahepatic metastasis to lung (n = 23), bone (n = 10) and lymph node (n = 3) were detected in 36 (18.5%) patients. Most patients had advanced HCC-88 (45.1%) in stage III and 57 (29.2%) in stage IV. Surgical resection was performed in 27 (13.8%) patients,RFAin 23 (11.8%) andTACEin 107 (54.9%).When all the patients were categorized as 'treated' (n = 156) and 'not treated' (n = 39), the 3-year survival was significantly lower in the 'not treated' group than in the 'treated' group (11 vs. 0%, P<0.001). Tumor diameter (≥3 cm vs. C3 cm), extrahepatic metastasis, TNM stage (I/II vs. III/IV) and treatment (or supportive care) were selected as independent predictors for survival. Conclusions High proportion of patients with HCC in Mongolia is diagnosed at an advanced stage and survival of these patients is lower compared to other countries. A surveillance system and referral policy for high-risk groups should be urgently established and implemented in Mongolia.

AB - Purpose Hepatocellular carcinoma (HCC) is the most common cancer in Mongolia. We aimed to investigate the clinical features, therapeutic modalities, overall survival and prognostic factors for Mongolian patients with HCC. Method One hundred ninety-five patients with HCC were consecutively enroled in our study. Results The mean age was 61.7 years. The most common etiology for HCC was HCV infection (n = 89, 45.6%), followed by HBV infection (n = 67, 34.4%). The mean tumor diameter was 6.0 ± 2.6 cm. Only 29 (14.9%) patients had a single lesion, while 39 (20.2%) had[3 lesions. Extrahepatic metastasis to lung (n = 23), bone (n = 10) and lymph node (n = 3) were detected in 36 (18.5%) patients. Most patients had advanced HCC-88 (45.1%) in stage III and 57 (29.2%) in stage IV. Surgical resection was performed in 27 (13.8%) patients,RFAin 23 (11.8%) andTACEin 107 (54.9%).When all the patients were categorized as 'treated' (n = 156) and 'not treated' (n = 39), the 3-year survival was significantly lower in the 'not treated' group than in the 'treated' group (11 vs. 0%, P<0.001). Tumor diameter (≥3 cm vs. C3 cm), extrahepatic metastasis, TNM stage (I/II vs. III/IV) and treatment (or supportive care) were selected as independent predictors for survival. Conclusions High proportion of patients with HCC in Mongolia is diagnosed at an advanced stage and survival of these patients is lower compared to other countries. A surveillance system and referral policy for high-risk groups should be urgently established and implemented in Mongolia.

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U2 - 10.1007/s12072-011-9325-4

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