Clinical features and prognosis of hepatocellular carcinoma in young patients from a hepatitis B-endemic area

Jeong Hwan Kim, Moon Seok Choi, Hyuk Lee, doyoung kim, Joon Hyeok Lee, Kwang Cheol Koh, Byung Chul Yoo, Seung Woon Paik, Jong Chul Rhee

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Abstract

Background and Aim: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. However, the clinical features of young HCC patients have not been fully studied. In the present study, we investigated the prevalence, clinical characteristics and prognosis of young HCC patients. Methods: A retrospective analysis was performed for HCC patients in our center using Korean cancer registry data. Among 4234 patients enrolled, there were 38 patients younger than 30 years of age (0.9%). We compared clinical characteristics and survival data of these patients (group I) with those of sex-matched, randomly selected HCC patients aged 30-59 years (group II; n = 231) and 60 years or older (group III; n = 147). Results: Group I showed distinct features compared with groups II and III as follows: low frequency of smoking history, high positive rate of hepatitis B s antigen, no association with anti-hepatitis C virus antibody, high frequency of α-fetoprotein ≥400 ng/mL, well-preserved liver function, larger tumor size, more advanced tumor-node-metastasis (TNM) stage and Cancer of the Liver Italian Program (CLIP) score and more frequent application of surgical resection and chemotherapy as initial treatment. The overall survival of group I was worse than that of group II, but similar to that of group III. Multivariate analysis showed that TNM stage and CLIP score, not age itself, were independent predictive factors for survival. Conclusions: The results suggest that young HCC patients tend to have a poor prognosis owing to advanced tumor stage, despite well-preserved liver function and aggressive treatment. Further studies regarding the role of HCC screening in young people may be useful, especially in hepatitis B virus carriers from high endemic areas.

Original languageEnglish
Pages (from-to)588-594
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume21
Issue number3
DOIs
Publication statusPublished - 2006 Jan 1

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Hepatitis B
Hepatocellular Carcinoma
Neoplasms
Liver Neoplasms
Survival
Fetal Proteins
Neoplasm Metastasis
Hepatitis B Antigens
Hepatitis C Antibodies
Liver
Hepatitis B virus
Registries
Multivariate Analysis
Smoking
History
Drug Therapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kim, Jeong Hwan ; Choi, Moon Seok ; Lee, Hyuk ; kim, doyoung ; Lee, Joon Hyeok ; Koh, Kwang Cheol ; Yoo, Byung Chul ; Paik, Seung Woon ; Rhee, Jong Chul. / Clinical features and prognosis of hepatocellular carcinoma in young patients from a hepatitis B-endemic area. In: Journal of Gastroenterology and Hepatology (Australia). 2006 ; Vol. 21, No. 3. pp. 588-594.
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Clinical features and prognosis of hepatocellular carcinoma in young patients from a hepatitis B-endemic area. / Kim, Jeong Hwan; Choi, Moon Seok; Lee, Hyuk; kim, doyoung; Lee, Joon Hyeok; Koh, Kwang Cheol; Yoo, Byung Chul; Paik, Seung Woon; Rhee, Jong Chul.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 21, No. 3, 01.01.2006, p. 588-594.

Research output: Contribution to journalArticle

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T1 - Clinical features and prognosis of hepatocellular carcinoma in young patients from a hepatitis B-endemic area

AU - Kim, Jeong Hwan

AU - Choi, Moon Seok

AU - Lee, Hyuk

AU - kim, doyoung

AU - Lee, Joon Hyeok

AU - Koh, Kwang Cheol

AU - Yoo, Byung Chul

AU - Paik, Seung Woon

AU - Rhee, Jong Chul

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Background and Aim: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. However, the clinical features of young HCC patients have not been fully studied. In the present study, we investigated the prevalence, clinical characteristics and prognosis of young HCC patients. Methods: A retrospective analysis was performed for HCC patients in our center using Korean cancer registry data. Among 4234 patients enrolled, there were 38 patients younger than 30 years of age (0.9%). We compared clinical characteristics and survival data of these patients (group I) with those of sex-matched, randomly selected HCC patients aged 30-59 years (group II; n = 231) and 60 years or older (group III; n = 147). Results: Group I showed distinct features compared with groups II and III as follows: low frequency of smoking history, high positive rate of hepatitis B s antigen, no association with anti-hepatitis C virus antibody, high frequency of α-fetoprotein ≥400 ng/mL, well-preserved liver function, larger tumor size, more advanced tumor-node-metastasis (TNM) stage and Cancer of the Liver Italian Program (CLIP) score and more frequent application of surgical resection and chemotherapy as initial treatment. The overall survival of group I was worse than that of group II, but similar to that of group III. Multivariate analysis showed that TNM stage and CLIP score, not age itself, were independent predictive factors for survival. Conclusions: The results suggest that young HCC patients tend to have a poor prognosis owing to advanced tumor stage, despite well-preserved liver function and aggressive treatment. Further studies regarding the role of HCC screening in young people may be useful, especially in hepatitis B virus carriers from high endemic areas.

AB - Background and Aim: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. However, the clinical features of young HCC patients have not been fully studied. In the present study, we investigated the prevalence, clinical characteristics and prognosis of young HCC patients. Methods: A retrospective analysis was performed for HCC patients in our center using Korean cancer registry data. Among 4234 patients enrolled, there were 38 patients younger than 30 years of age (0.9%). We compared clinical characteristics and survival data of these patients (group I) with those of sex-matched, randomly selected HCC patients aged 30-59 years (group II; n = 231) and 60 years or older (group III; n = 147). Results: Group I showed distinct features compared with groups II and III as follows: low frequency of smoking history, high positive rate of hepatitis B s antigen, no association with anti-hepatitis C virus antibody, high frequency of α-fetoprotein ≥400 ng/mL, well-preserved liver function, larger tumor size, more advanced tumor-node-metastasis (TNM) stage and Cancer of the Liver Italian Program (CLIP) score and more frequent application of surgical resection and chemotherapy as initial treatment. The overall survival of group I was worse than that of group II, but similar to that of group III. Multivariate analysis showed that TNM stage and CLIP score, not age itself, were independent predictive factors for survival. Conclusions: The results suggest that young HCC patients tend to have a poor prognosis owing to advanced tumor stage, despite well-preserved liver function and aggressive treatment. Further studies regarding the role of HCC screening in young people may be useful, especially in hepatitis B virus carriers from high endemic areas.

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