Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis

Seok Seo Yeon, Ho Kim Youn, Hoon Ahn Sang, Kyun Yu Sang, Koo Baik Soon, Kyu Choi Sung, Jeong Heo, Taeho Hahn, Woo Yoo Tae, Hyun Cho Se, Woong Lee Hyun, Hyun Kim Ju, Mong Cho, Hoon Park Sang, Ik Kim Byung, Hyub Han Kwang, Ho Um Soon

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

With recent progress in treatment modalities, mortality from upper gastrointestinal (UGI) bleeding has decreased appreciably. The aim of this study was to establish how UGI bleeds are managed in Korean patients with cirrhosis and to evaluate treatment outcomes. A total of 479 episodes of acute UGI bleeding in 464 patients with cirrhosis were included during a six-month period at nine tertiary medical centers. Treatment outcomes were assessed by failure to control bleeding, rebleeding and mortality. The source of bleeding was esophagogastric varices in 77.7% of patients, nonvariceal lesions in 15.9%, and undefined in 6.5%. For control of bleeding, endoscopic and pharmacologic treatments were used in 74.7% and 81.9% of patients, respectively. Variceal ligation was a major technique for endoscopic treatment (90%), and terlipressin and somatostatin were the main pharmacologic agents used (96.4%). Initial hemostasis was achieved in 86.8% of cases, but rebleeding occurred in 3.8% and 16.8% of cases within five days and six weeks of hemorrhage, respectively. Five-day and six-week mortality were 11.3% and 25.9%, respectively. Survival of patients with variceal bleeding seems to be remarkably improved than previous reports, which may suggest the advances in hemostatic methods for control of variceal hemorrhage.

Original languageEnglish
Pages (from-to)635-643
Number of pages9
JournalJournal of Korean medical science
Volume23
Issue number4
DOIs
Publication statusPublished - 2008 Aug 1

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Fibrosis
Hemorrhage
Mortality
Varicose Veins
Hemostatics
Somatostatin
Hemostasis
Ligation
Therapeutics
Survival

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yeon, Seok Seo ; Youn, Ho Kim ; Sang, Hoon Ahn ; Sang, Kyun Yu ; Soon, Koo Baik ; Sung, Kyu Choi ; Heo, Jeong ; Hahn, Taeho ; Tae, Woo Yoo ; Se, Hyun Cho ; Hyun, Woong Lee ; Ju, Hyun Kim ; Cho, Mong ; Sang, Hoon Park ; Byung, Ik Kim ; Kwang, Hyub Han ; Soon, Ho Um. / Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis. In: Journal of Korean medical science. 2008 ; Vol. 23, No. 4. pp. 635-643.
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abstract = "With recent progress in treatment modalities, mortality from upper gastrointestinal (UGI) bleeding has decreased appreciably. The aim of this study was to establish how UGI bleeds are managed in Korean patients with cirrhosis and to evaluate treatment outcomes. A total of 479 episodes of acute UGI bleeding in 464 patients with cirrhosis were included during a six-month period at nine tertiary medical centers. Treatment outcomes were assessed by failure to control bleeding, rebleeding and mortality. The source of bleeding was esophagogastric varices in 77.7{\%} of patients, nonvariceal lesions in 15.9{\%}, and undefined in 6.5{\%}. For control of bleeding, endoscopic and pharmacologic treatments were used in 74.7{\%} and 81.9{\%} of patients, respectively. Variceal ligation was a major technique for endoscopic treatment (90{\%}), and terlipressin and somatostatin were the main pharmacologic agents used (96.4{\%}). Initial hemostasis was achieved in 86.8{\%} of cases, but rebleeding occurred in 3.8{\%} and 16.8{\%} of cases within five days and six weeks of hemorrhage, respectively. Five-day and six-week mortality were 11.3{\%} and 25.9{\%}, respectively. Survival of patients with variceal bleeding seems to be remarkably improved than previous reports, which may suggest the advances in hemostatic methods for control of variceal hemorrhage.",
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Yeon, SS, Youn, HK, Sang, HA, Sang, KY, Soon, KB, Sung, KC, Heo, J, Hahn, T, Tae, WY, Se, HC, Hyun, WL, Ju, HK, Cho, M, Sang, HP, Byung, IK, Kwang, HH & Soon, HU 2008, 'Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis', Journal of Korean medical science, vol. 23, no. 4, pp. 635-643. https://doi.org/10.3346/jkms.2008.23.4.635

Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis. / Yeon, Seok Seo; Youn, Ho Kim; Sang, Hoon Ahn; Sang, Kyun Yu; Soon, Koo Baik; Sung, Kyu Choi; Heo, Jeong; Hahn, Taeho; Tae, Woo Yoo; Se, Hyun Cho; Hyun, Woong Lee; Ju, Hyun Kim; Cho, Mong; Sang, Hoon Park; Byung, Ik Kim; Kwang, Hyub Han; Soon, Ho Um.

In: Journal of Korean medical science, Vol. 23, No. 4, 01.08.2008, p. 635-643.

Research output: Contribution to journalArticle

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T1 - Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis

AU - Yeon, Seok Seo

AU - Youn, Ho Kim

AU - Sang, Hoon Ahn

AU - Sang, Kyun Yu

AU - Soon, Koo Baik

AU - Sung, Kyu Choi

AU - Heo, Jeong

AU - Hahn, Taeho

AU - Tae, Woo Yoo

AU - Se, Hyun Cho

AU - Hyun, Woong Lee

AU - Ju, Hyun Kim

AU - Cho, Mong

AU - Sang, Hoon Park

AU - Byung, Ik Kim

AU - Kwang, Hyub Han

AU - Soon, Ho Um

PY - 2008/8/1

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