Abstract
Inflammatory pseudotumor (IPT) of the liver is a rare disease characterized by chronic infiltration of inflammatory cells. However, the clinical characteristics and outcomes of IPT remain uncertain. Clinical features, image findings, and outcomes of 55 patients with histologically proven IPT were evaluated. They consisted of 26 men and 19 women with median age of 65 years. Serum carcinoembryonal antigen and carbohydrate antigen 19-9 levels were normal in 42 patients (93.3%). Enhanced CT scans indicated poorly defined peripheral enhancement (82.5%) at the arterial phase and poorly defined hyperattenuating lesions with internal hypoattenuating areas at the equilibrium phase (77.0%). Gadolinium-enhancement MRI revealed poorly defined peripheral rim-like enhancement (77.8%). Ten patients underwent surgical resection and 35 were treated conservatively with or without antibiotics. No recurrence was noted after surgical resection during follow-up (1 to 48 months). In all patients who received conservative treatment, complete resolution or size reduction was noted during follow-up (1 to 192 months). CT and MRI provide clues to the diagnosis of IPT in patients with liver masses and normal tumor markers. However, due to the lack of pathognomonic findings, the clinician's suspicion and histological diagnosis are necessary to make an accurate diagnosis of IPT.
| Original language | English |
|---|---|
| Pages (from-to) | 58-63 |
| Number of pages | 6 |
| Journal | Gut and liver |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Jan |
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All Science Journal Classification (ASJC) codes
- Hepatology
- Gastroenterology
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Clinical features, image findings, and prognosis of inflammatory pseudotumor of the liver : a multicenter experience of 45 cases. / Park, Jun Young; Choi, Moon Seok; Lim, Young Suk; Park, Jang Won; Kim, Seung Up; Min, Yang Won; Gwak, Geum Youn; Paik, Yong Han; Lee, Joon Hyoek; Koh, Kwang Cheol; Paik, Seung Woon; Yoo, Byung Chul.
In: Gut and liver, Vol. 8, No. 1, 01.2014, p. 58-63.Research output: Contribution to journal › Article
TY - JOUR
T1 - Clinical features, image findings, and prognosis of inflammatory pseudotumor of the liver
T2 - a multicenter experience of 45 cases.
AU - Park, Jun Young
AU - Choi, Moon Seok
AU - Lim, Young Suk
AU - Park, Jang Won
AU - Kim, Seung Up
AU - Min, Yang Won
AU - Gwak, Geum Youn
AU - Paik, Yong Han
AU - Lee, Joon Hyoek
AU - Koh, Kwang Cheol
AU - Paik, Seung Woon
AU - Yoo, Byung Chul
PY - 2014/1
Y1 - 2014/1
N2 - Inflammatory pseudotumor (IPT) of the liver is a rare disease characterized by chronic infiltration of inflammatory cells. However, the clinical characteristics and outcomes of IPT remain uncertain. Clinical features, image findings, and outcomes of 55 patients with histologically proven IPT were evaluated. They consisted of 26 men and 19 women with median age of 65 years. Serum carcinoembryonal antigen and carbohydrate antigen 19-9 levels were normal in 42 patients (93.3%). Enhanced CT scans indicated poorly defined peripheral enhancement (82.5%) at the arterial phase and poorly defined hyperattenuating lesions with internal hypoattenuating areas at the equilibrium phase (77.0%). Gadolinium-enhancement MRI revealed poorly defined peripheral rim-like enhancement (77.8%). Ten patients underwent surgical resection and 35 were treated conservatively with or without antibiotics. No recurrence was noted after surgical resection during follow-up (1 to 48 months). In all patients who received conservative treatment, complete resolution or size reduction was noted during follow-up (1 to 192 months). CT and MRI provide clues to the diagnosis of IPT in patients with liver masses and normal tumor markers. However, due to the lack of pathognomonic findings, the clinician's suspicion and histological diagnosis are necessary to make an accurate diagnosis of IPT.
AB - Inflammatory pseudotumor (IPT) of the liver is a rare disease characterized by chronic infiltration of inflammatory cells. However, the clinical characteristics and outcomes of IPT remain uncertain. Clinical features, image findings, and outcomes of 55 patients with histologically proven IPT were evaluated. They consisted of 26 men and 19 women with median age of 65 years. Serum carcinoembryonal antigen and carbohydrate antigen 19-9 levels were normal in 42 patients (93.3%). Enhanced CT scans indicated poorly defined peripheral enhancement (82.5%) at the arterial phase and poorly defined hyperattenuating lesions with internal hypoattenuating areas at the equilibrium phase (77.0%). Gadolinium-enhancement MRI revealed poorly defined peripheral rim-like enhancement (77.8%). Ten patients underwent surgical resection and 35 were treated conservatively with or without antibiotics. No recurrence was noted after surgical resection during follow-up (1 to 48 months). In all patients who received conservative treatment, complete resolution or size reduction was noted during follow-up (1 to 192 months). CT and MRI provide clues to the diagnosis of IPT in patients with liver masses and normal tumor markers. However, due to the lack of pathognomonic findings, the clinician's suspicion and histological diagnosis are necessary to make an accurate diagnosis of IPT.
UR - http://www.scopus.com/inward/record.url?scp=84899978569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899978569&partnerID=8YFLogxK
U2 - 10.5009/gnl.2014.8.1.58
DO - 10.5009/gnl.2014.8.1.58
M3 - Article
C2 - 24516702
AN - SCOPUS:84899978569
VL - 8
SP - 58
EP - 63
JO - Gut and Liver
JF - Gut and Liver
SN - 1976-2283
IS - 1
ER -