Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients

S. Y. Jang, S. Y. Lee, Eunjig Lee, Jinsook Yoon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

AimTo compare clinical characteristics and thyroid-stimulating hormone receptor antibodies (TRAbs) in thyroid-associated ophthalmopathy (TAO) in euthyroid Korean patients with those in hyperthyroid patients.MethodsClinical activity scores (CASs), modified NOSPECS scores, exophthalmometry values, prevalence of optic neuropathy, restrictive myopathy and lid retraction, and the positivity and levels of TRAb (thyrotropin-binding inhibitor immunoglobulin (TBII) and thyroid-stimulating immunoglobulin (TSI)) were compared in 24 euthyroid (group A) and 139 clinical/subclinical hyperthyroid TAO patients (group B).ResultsGroup A presented more clinically unilateral involvement than group B (79.2% vs 27.3%, P0.001), less active (CAS 1.50 vs 2.26, P0.014) and less severe clinical course (NOSPECS 3.38 vs 4.13, P0.037). Lid retraction was more prevalent in group A than group B (91.7% vs 66.2%, P0.014). Prevalence of optic neuropathy and restrictive myopathy, and the mean value of exophthalmometry were not different. Mean TBII levels were lower (7.20 IU/l) in group A than in group B (44.58 IU/l, P0.001). A similar difference was found in the TSI bioassay (201.40% vs 425.19%, P0.001). The positive rate of TBII in group A (34.8%) was significantly lower than in group B (90.8%, P0.001). The positive rate of TSI was high in both group A (83.3%) and B (91.7%), with no significant difference (P0.337).ConclusionsPatients with euthyroid TAO showed a less active and severe clinical course, more unilateral involvement, and lower levels of TRAb than those in patients with hyperthyroid TAO. These distinct clinical and biochemical characteristics might be useful in assessment of euthyroid TAO, and the TSI might be more sensitive for diagnosing these patients.

Original languageEnglish
Pages (from-to)1263-1269
Number of pages7
JournalEye (Basingstoke)
Volume26
Issue number9
DOIs
Publication statusPublished - 2012 Jan 1

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Graves Ophthalmopathy
Thyroid-Stimulating Immunoglobulins
Thyrotropin Receptors
Thyrotropin
Hyperthyroidism
Immunoglobulins
Optic Nerve Diseases
Muscular Diseases
Antibodies
Biological Assay

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems

Cite this

@article{50f8225e97c34908888c1a692b118008,
title = "Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients",
abstract = "AimTo compare clinical characteristics and thyroid-stimulating hormone receptor antibodies (TRAbs) in thyroid-associated ophthalmopathy (TAO) in euthyroid Korean patients with those in hyperthyroid patients.MethodsClinical activity scores (CASs), modified NOSPECS scores, exophthalmometry values, prevalence of optic neuropathy, restrictive myopathy and lid retraction, and the positivity and levels of TRAb (thyrotropin-binding inhibitor immunoglobulin (TBII) and thyroid-stimulating immunoglobulin (TSI)) were compared in 24 euthyroid (group A) and 139 clinical/subclinical hyperthyroid TAO patients (group B).ResultsGroup A presented more clinically unilateral involvement than group B (79.2{\%} vs 27.3{\%}, P0.001), less active (CAS 1.50 vs 2.26, P0.014) and less severe clinical course (NOSPECS 3.38 vs 4.13, P0.037). Lid retraction was more prevalent in group A than group B (91.7{\%} vs 66.2{\%}, P0.014). Prevalence of optic neuropathy and restrictive myopathy, and the mean value of exophthalmometry were not different. Mean TBII levels were lower (7.20 IU/l) in group A than in group B (44.58 IU/l, P0.001). A similar difference was found in the TSI bioassay (201.40{\%} vs 425.19{\%}, P0.001). The positive rate of TBII in group A (34.8{\%}) was significantly lower than in group B (90.8{\%}, P0.001). The positive rate of TSI was high in both group A (83.3{\%}) and B (91.7{\%}), with no significant difference (P0.337).ConclusionsPatients with euthyroid TAO showed a less active and severe clinical course, more unilateral involvement, and lower levels of TRAb than those in patients with hyperthyroid TAO. These distinct clinical and biochemical characteristics might be useful in assessment of euthyroid TAO, and the TSI might be more sensitive for diagnosing these patients.",
author = "Jang, {S. Y.} and Lee, {S. Y.} and Eunjig Lee and Jinsook Yoon",
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Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients. / Jang, S. Y.; Lee, S. Y.; Lee, Eunjig; Yoon, Jinsook.

In: Eye (Basingstoke), Vol. 26, No. 9, 01.01.2012, p. 1263-1269.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients

AU - Jang, S. Y.

AU - Lee, S. Y.

AU - Lee, Eunjig

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N2 - AimTo compare clinical characteristics and thyroid-stimulating hormone receptor antibodies (TRAbs) in thyroid-associated ophthalmopathy (TAO) in euthyroid Korean patients with those in hyperthyroid patients.MethodsClinical activity scores (CASs), modified NOSPECS scores, exophthalmometry values, prevalence of optic neuropathy, restrictive myopathy and lid retraction, and the positivity and levels of TRAb (thyrotropin-binding inhibitor immunoglobulin (TBII) and thyroid-stimulating immunoglobulin (TSI)) were compared in 24 euthyroid (group A) and 139 clinical/subclinical hyperthyroid TAO patients (group B).ResultsGroup A presented more clinically unilateral involvement than group B (79.2% vs 27.3%, P0.001), less active (CAS 1.50 vs 2.26, P0.014) and less severe clinical course (NOSPECS 3.38 vs 4.13, P0.037). Lid retraction was more prevalent in group A than group B (91.7% vs 66.2%, P0.014). Prevalence of optic neuropathy and restrictive myopathy, and the mean value of exophthalmometry were not different. Mean TBII levels were lower (7.20 IU/l) in group A than in group B (44.58 IU/l, P0.001). A similar difference was found in the TSI bioassay (201.40% vs 425.19%, P0.001). The positive rate of TBII in group A (34.8%) was significantly lower than in group B (90.8%, P0.001). The positive rate of TSI was high in both group A (83.3%) and B (91.7%), with no significant difference (P0.337).ConclusionsPatients with euthyroid TAO showed a less active and severe clinical course, more unilateral involvement, and lower levels of TRAb than those in patients with hyperthyroid TAO. These distinct clinical and biochemical characteristics might be useful in assessment of euthyroid TAO, and the TSI might be more sensitive for diagnosing these patients.

AB - AimTo compare clinical characteristics and thyroid-stimulating hormone receptor antibodies (TRAbs) in thyroid-associated ophthalmopathy (TAO) in euthyroid Korean patients with those in hyperthyroid patients.MethodsClinical activity scores (CASs), modified NOSPECS scores, exophthalmometry values, prevalence of optic neuropathy, restrictive myopathy and lid retraction, and the positivity and levels of TRAb (thyrotropin-binding inhibitor immunoglobulin (TBII) and thyroid-stimulating immunoglobulin (TSI)) were compared in 24 euthyroid (group A) and 139 clinical/subclinical hyperthyroid TAO patients (group B).ResultsGroup A presented more clinically unilateral involvement than group B (79.2% vs 27.3%, P0.001), less active (CAS 1.50 vs 2.26, P0.014) and less severe clinical course (NOSPECS 3.38 vs 4.13, P0.037). Lid retraction was more prevalent in group A than group B (91.7% vs 66.2%, P0.014). Prevalence of optic neuropathy and restrictive myopathy, and the mean value of exophthalmometry were not different. Mean TBII levels were lower (7.20 IU/l) in group A than in group B (44.58 IU/l, P0.001). A similar difference was found in the TSI bioassay (201.40% vs 425.19%, P0.001). The positive rate of TBII in group A (34.8%) was significantly lower than in group B (90.8%, P0.001). The positive rate of TSI was high in both group A (83.3%) and B (91.7%), with no significant difference (P0.337).ConclusionsPatients with euthyroid TAO showed a less active and severe clinical course, more unilateral involvement, and lower levels of TRAb than those in patients with hyperthyroid TAO. These distinct clinical and biochemical characteristics might be useful in assessment of euthyroid TAO, and the TSI might be more sensitive for diagnosing these patients.

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