Clinical implication of an insufficient number of examined lymph nodes after curative resection for gastric cancer

Taeil Son, WooJin Hyung, Joong Ho Lee, Yoo Min Kim, Hyoung Il Kim, Ji Yeong An, Jae Ho Cheong, Sung Hoon Noh

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

BACKGROUND: The seventh edition of the tumor, lymph node (LN), metastasis (TNM) staging system increased the required number of examined LNs in gastric cancer from 15 to 16. However, the same staging system defines lymph node-negative gastric cancer regardless of the number of examined LNs. In this study, the authors evaluated whether gastric cancer can be staged properly with fewer than 15 examined LNs. METHODS: The survival rates of 10,010 patients who underwent curative gastrectomy from 1987 to 2007 were analyzed. The patients were divided into 2 groups according to the number of examined LNs, termed the "insufficient" group (≥15 examined LNs) and the "group (≥16 examined LNs). The survival curves of patients from both groups were compared according to the seventh edition of the TNM classification. RESULTS: Three hundred sixteen patients (3.2%) had a;circ15 examined LNs for staging after they underwent standard, curative lymphadenectomy. Patients who had T1 tumor classification, N0 lymph node status, and stage I disease with an insufficient number of examined LNs after curative gastrectomy had a significantly worse prognosis than patients who had ≥yen;16 examined LNs. Moreover, having an insufficient number of examined LNs was an independent prognostic factor for patients who had T1, N0, and stage I disease. CONCLUSIONS: Lymph node-negative cancers in which ≥15 LNs were examined, classified as N0 in the new TNM staging system, could not adequately predict patient survival after curative gastrectomy, especially in patients with early stage gastric cancer.

Original languageEnglish
Pages (from-to)4687-4693
Number of pages7
JournalCancer
Volume118
Issue number19
DOIs
Publication statusPublished - 2012 Oct 1

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Stomach Neoplasms
Lymph Nodes
Neoplasm Staging
Gastrectomy
Neoplasms
Survival
Lymph Node Excision
Survival Rate
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Son, Taeil ; Hyung, WooJin ; Lee, Joong Ho ; Kim, Yoo Min ; Kim, Hyoung Il ; An, Ji Yeong ; Cheong, Jae Ho ; Noh, Sung Hoon. / Clinical implication of an insufficient number of examined lymph nodes after curative resection for gastric cancer. In: Cancer. 2012 ; Vol. 118, No. 19. pp. 4687-4693.
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abstract = "BACKGROUND: The seventh edition of the tumor, lymph node (LN), metastasis (TNM) staging system increased the required number of examined LNs in gastric cancer from 15 to 16. However, the same staging system defines lymph node-negative gastric cancer regardless of the number of examined LNs. In this study, the authors evaluated whether gastric cancer can be staged properly with fewer than 15 examined LNs. METHODS: The survival rates of 10,010 patients who underwent curative gastrectomy from 1987 to 2007 were analyzed. The patients were divided into 2 groups according to the number of examined LNs, termed the {"}insufficient{"} group (≥15 examined LNs) and the {"}group (≥16 examined LNs). The survival curves of patients from both groups were compared according to the seventh edition of the TNM classification. RESULTS: Three hundred sixteen patients (3.2{\%}) had a;circ15 examined LNs for staging after they underwent standard, curative lymphadenectomy. Patients who had T1 tumor classification, N0 lymph node status, and stage I disease with an insufficient number of examined LNs after curative gastrectomy had a significantly worse prognosis than patients who had ≥yen;16 examined LNs. Moreover, having an insufficient number of examined LNs was an independent prognostic factor for patients who had T1, N0, and stage I disease. CONCLUSIONS: Lymph node-negative cancers in which ≥15 LNs were examined, classified as N0 in the new TNM staging system, could not adequately predict patient survival after curative gastrectomy, especially in patients with early stage gastric cancer.",
author = "Taeil Son and WooJin Hyung and Lee, {Joong Ho} and Kim, {Yoo Min} and Kim, {Hyoung Il} and An, {Ji Yeong} and Cheong, {Jae Ho} and Noh, {Sung Hoon}",
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Clinical implication of an insufficient number of examined lymph nodes after curative resection for gastric cancer. / Son, Taeil; Hyung, WooJin; Lee, Joong Ho; Kim, Yoo Min; Kim, Hyoung Il; An, Ji Yeong; Cheong, Jae Ho; Noh, Sung Hoon.

In: Cancer, Vol. 118, No. 19, 01.10.2012, p. 4687-4693.

Research output: Contribution to journalArticle

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T1 - Clinical implication of an insufficient number of examined lymph nodes after curative resection for gastric cancer

AU - Son, Taeil

AU - Hyung, WooJin

AU - Lee, Joong Ho

AU - Kim, Yoo Min

AU - Kim, Hyoung Il

AU - An, Ji Yeong

AU - Cheong, Jae Ho

AU - Noh, Sung Hoon

PY - 2012/10/1

Y1 - 2012/10/1

N2 - BACKGROUND: The seventh edition of the tumor, lymph node (LN), metastasis (TNM) staging system increased the required number of examined LNs in gastric cancer from 15 to 16. However, the same staging system defines lymph node-negative gastric cancer regardless of the number of examined LNs. In this study, the authors evaluated whether gastric cancer can be staged properly with fewer than 15 examined LNs. METHODS: The survival rates of 10,010 patients who underwent curative gastrectomy from 1987 to 2007 were analyzed. The patients were divided into 2 groups according to the number of examined LNs, termed the "insufficient" group (≥15 examined LNs) and the "group (≥16 examined LNs). The survival curves of patients from both groups were compared according to the seventh edition of the TNM classification. RESULTS: Three hundred sixteen patients (3.2%) had a;circ15 examined LNs for staging after they underwent standard, curative lymphadenectomy. Patients who had T1 tumor classification, N0 lymph node status, and stage I disease with an insufficient number of examined LNs after curative gastrectomy had a significantly worse prognosis than patients who had ≥yen;16 examined LNs. Moreover, having an insufficient number of examined LNs was an independent prognostic factor for patients who had T1, N0, and stage I disease. CONCLUSIONS: Lymph node-negative cancers in which ≥15 LNs were examined, classified as N0 in the new TNM staging system, could not adequately predict patient survival after curative gastrectomy, especially in patients with early stage gastric cancer.

AB - BACKGROUND: The seventh edition of the tumor, lymph node (LN), metastasis (TNM) staging system increased the required number of examined LNs in gastric cancer from 15 to 16. However, the same staging system defines lymph node-negative gastric cancer regardless of the number of examined LNs. In this study, the authors evaluated whether gastric cancer can be staged properly with fewer than 15 examined LNs. METHODS: The survival rates of 10,010 patients who underwent curative gastrectomy from 1987 to 2007 were analyzed. The patients were divided into 2 groups according to the number of examined LNs, termed the "insufficient" group (≥15 examined LNs) and the "group (≥16 examined LNs). The survival curves of patients from both groups were compared according to the seventh edition of the TNM classification. RESULTS: Three hundred sixteen patients (3.2%) had a;circ15 examined LNs for staging after they underwent standard, curative lymphadenectomy. Patients who had T1 tumor classification, N0 lymph node status, and stage I disease with an insufficient number of examined LNs after curative gastrectomy had a significantly worse prognosis than patients who had ≥yen;16 examined LNs. Moreover, having an insufficient number of examined LNs was an independent prognostic factor for patients who had T1, N0, and stage I disease. CONCLUSIONS: Lymph node-negative cancers in which ≥15 LNs were examined, classified as N0 in the new TNM staging system, could not adequately predict patient survival after curative gastrectomy, especially in patients with early stage gastric cancer.

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