Clinical implication of highly sensitive detection of the BRAFV600E mutation in fine-needle aspirations according to the thyroid bethesda system in patients with conventional papillary thyroid carcinoma

Jae Young Seo, Jong Rak Choi, Hee Jung Moon, Eun Kyung Kim, Kyung Hwa Han, Hyunki Kim, Jin Young Kwak

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAFV600E mutation status. Materials and Methods: During the study period, 279 patients who underwent FNA with an additional BRAFV600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. Results: Of the 279 cPTCs, 250 (89.6%) had the BRAFV600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19% (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. Conclusions: Suspicious US features may be helpful in deciding whether an additional BRAFV600E mutation test should be done in thyroid nodules with indeterminate cytology.

Original languageEnglish
Pages (from-to)392-399
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Volume124
Issue number5
DOIs
Publication statusPublished - 2015 May 1

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education (2013R1A1A2058817).

Publisher Copyright:
© 2014 The Author(s).

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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