Clinical implication of highly sensitive detection of the BRAFV600E mutation in fine-needle aspirations according to the thyroid bethesda system in patients with conventional papillary thyroid carcinoma

Jae Young Seo, Jong Rak Choi, Hee Jung Moon, Eunkyung Kim, Kyung Hwa Han, Hyunki Kim, jinyoung kwak

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7 Citations (Scopus)

Abstract

Background: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAFV600E mutation status. Materials and Methods: During the study period, 279 patients who underwent FNA with an additional BRAFV600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. Results: Of the 279 cPTCs, 250 (89.6%) had the BRAFV600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19% (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. Conclusions: Suspicious US features may be helpful in deciding whether an additional BRAFV600E mutation test should be done in thyroid nodules with indeterminate cytology.

Original languageEnglish
Pages (from-to)392-399
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Volume124
Issue number5
DOIs
Publication statusPublished - 2015 May 1

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Fine Needle Biopsy
Thyroid Gland
Mutation
Factor IX
Mutation Rate
Thyroid Nodule
Papillary Thyroid cancer
Cell Biology

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

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title = "Clinical implication of highly sensitive detection of the BRAFV600E mutation in fine-needle aspirations according to the thyroid bethesda system in patients with conventional papillary thyroid carcinoma",
abstract = "Background: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAFV600E mutation status. Materials and Methods: During the study period, 279 patients who underwent FNA with an additional BRAFV600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. Results: Of the 279 cPTCs, 250 (89.6{\%}) had the BRAFV600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19{\%} (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. Conclusions: Suspicious US features may be helpful in deciding whether an additional BRAFV600E mutation test should be done in thyroid nodules with indeterminate cytology.",
author = "Seo, {Jae Young} and Choi, {Jong Rak} and Moon, {Hee Jung} and Eunkyung Kim and Han, {Kyung Hwa} and Hyunki Kim and jinyoung kwak",
year = "2015",
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volume = "124",
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T1 - Clinical implication of highly sensitive detection of the BRAFV600E mutation in fine-needle aspirations according to the thyroid bethesda system in patients with conventional papillary thyroid carcinoma

AU - Seo, Jae Young

AU - Choi, Jong Rak

AU - Moon, Hee Jung

AU - Kim, Eunkyung

AU - Han, Kyung Hwa

AU - Kim, Hyunki

AU - kwak, jinyoung

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAFV600E mutation status. Materials and Methods: During the study period, 279 patients who underwent FNA with an additional BRAFV600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. Results: Of the 279 cPTCs, 250 (89.6%) had the BRAFV600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19% (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. Conclusions: Suspicious US features may be helpful in deciding whether an additional BRAFV600E mutation test should be done in thyroid nodules with indeterminate cytology.

AB - Background: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAFV600E mutation status. Materials and Methods: During the study period, 279 patients who underwent FNA with an additional BRAFV600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. Results: Of the 279 cPTCs, 250 (89.6%) had the BRAFV600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19% (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. Conclusions: Suspicious US features may be helpful in deciding whether an additional BRAFV600E mutation test should be done in thyroid nodules with indeterminate cytology.

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