Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients

Sun Min Lim, Minkyu Jung, Sang Joon Shin, Se Jin Baek, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Nam Kyu Kim, Joong Bae Ahn

Research output: Contribution to journalArticle

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Abstract

Background: With the increasing burden of organ transplant recipients and improvements in allograft outcome, the incidence of neoplasms rising from these patients is an important issue. Objective: In this study, we investigated transplant recipients with colorectal cancer to determine its incidence, clinicopathological characteristics, and prognosis. Methods: The database of Severance Hospital was queried for all cases of colorectal adenocarcinoma among transplant recipients from August 2005 to January 2013. Results: A total of 29 patients were diagnosed with colorectal adenocarcinoma after transplantation, and the median age at diagnosis was 58.6 years. As for primary tumor stage, 17 (58.6%) patients had stage ≥3, and distant metastasis was found in 10 (34.4%) patients. The mean time from transplantation to tumor detection was 13.7 years. The median disease-free survival was 11.0 months and the median overall survival (OS) was 18.1 months. In multivariate analysis of prognostic factors for OS, surgical resection was a positive prognostic factor (HR 1.357, p = 0.010) and the presence of distant metastasis at diagnosis was a negative prognostic factor (HR 1.047, p = 0.006). Conclusion: The behavior of colorectal cancer in posttransplant patients is more aggressive and refractory to treatment. A separate guideline for the colorectal screening program for the posttransplant patients needs to be established.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalOncology (Switzerland)
Volume88
Issue number4
DOIs
Publication statusPublished - 2014 Apr 6

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Adenocarcinoma
Colorectal Neoplasms
Transplantation
Neoplasm Metastasis
Neoplasms
Survival
Incidence
Disease-Free Survival
Allografts
Transplant Recipients
Multivariate Analysis
Databases
Guidelines
Transplants
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lim, S. M., Jung, M., Shin, S. J., Baek, S. J., Hur, H., Min, B. S., ... Ahn, J. B. (2014). Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients. Oncology (Switzerland), 88(4), 195-200. https://doi.org/10.1159/000369254
Lim, Sun Min ; Jung, Minkyu ; Shin, Sang Joon ; Baek, Se Jin ; Hur, Hyuk ; Min, Byung Soh ; Baik, Seung Hyuk ; Kim, Nam Kyu ; Ahn, Joong Bae. / Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients. In: Oncology (Switzerland). 2014 ; Vol. 88, No. 4. pp. 195-200.
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abstract = "Background: With the increasing burden of organ transplant recipients and improvements in allograft outcome, the incidence of neoplasms rising from these patients is an important issue. Objective: In this study, we investigated transplant recipients with colorectal cancer to determine its incidence, clinicopathological characteristics, and prognosis. Methods: The database of Severance Hospital was queried for all cases of colorectal adenocarcinoma among transplant recipients from August 2005 to January 2013. Results: A total of 29 patients were diagnosed with colorectal adenocarcinoma after transplantation, and the median age at diagnosis was 58.6 years. As for primary tumor stage, 17 (58.6{\%}) patients had stage ≥3, and distant metastasis was found in 10 (34.4{\%}) patients. The mean time from transplantation to tumor detection was 13.7 years. The median disease-free survival was 11.0 months and the median overall survival (OS) was 18.1 months. In multivariate analysis of prognostic factors for OS, surgical resection was a positive prognostic factor (HR 1.357, p = 0.010) and the presence of distant metastasis at diagnosis was a negative prognostic factor (HR 1.047, p = 0.006). Conclusion: The behavior of colorectal cancer in posttransplant patients is more aggressive and refractory to treatment. A separate guideline for the colorectal screening program for the posttransplant patients needs to be established.",
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Lim, SM, Jung, M, Shin, SJ, Baek, SJ, Hur, H, Min, BS, Baik, SH, Kim, NK & Ahn, JB 2014, 'Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients', Oncology (Switzerland), vol. 88, no. 4, pp. 195-200. https://doi.org/10.1159/000369254

Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients. / Lim, Sun Min; Jung, Minkyu; Shin, Sang Joon; Baek, Se Jin; Hur, Hyuk; Min, Byung Soh; Baik, Seung Hyuk; Kim, Nam Kyu; Ahn, Joong Bae.

In: Oncology (Switzerland), Vol. 88, No. 4, 06.04.2014, p. 195-200.

Research output: Contribution to journalArticle

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T1 - Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients

AU - Lim, Sun Min

AU - Jung, Minkyu

AU - Shin, Sang Joon

AU - Baek, Se Jin

AU - Hur, Hyuk

AU - Min, Byung Soh

AU - Baik, Seung Hyuk

AU - Kim, Nam Kyu

AU - Ahn, Joong Bae

PY - 2014/4/6

Y1 - 2014/4/6

N2 - Background: With the increasing burden of organ transplant recipients and improvements in allograft outcome, the incidence of neoplasms rising from these patients is an important issue. Objective: In this study, we investigated transplant recipients with colorectal cancer to determine its incidence, clinicopathological characteristics, and prognosis. Methods: The database of Severance Hospital was queried for all cases of colorectal adenocarcinoma among transplant recipients from August 2005 to January 2013. Results: A total of 29 patients were diagnosed with colorectal adenocarcinoma after transplantation, and the median age at diagnosis was 58.6 years. As for primary tumor stage, 17 (58.6%) patients had stage ≥3, and distant metastasis was found in 10 (34.4%) patients. The mean time from transplantation to tumor detection was 13.7 years. The median disease-free survival was 11.0 months and the median overall survival (OS) was 18.1 months. In multivariate analysis of prognostic factors for OS, surgical resection was a positive prognostic factor (HR 1.357, p = 0.010) and the presence of distant metastasis at diagnosis was a negative prognostic factor (HR 1.047, p = 0.006). Conclusion: The behavior of colorectal cancer in posttransplant patients is more aggressive and refractory to treatment. A separate guideline for the colorectal screening program for the posttransplant patients needs to be established.

AB - Background: With the increasing burden of organ transplant recipients and improvements in allograft outcome, the incidence of neoplasms rising from these patients is an important issue. Objective: In this study, we investigated transplant recipients with colorectal cancer to determine its incidence, clinicopathological characteristics, and prognosis. Methods: The database of Severance Hospital was queried for all cases of colorectal adenocarcinoma among transplant recipients from August 2005 to January 2013. Results: A total of 29 patients were diagnosed with colorectal adenocarcinoma after transplantation, and the median age at diagnosis was 58.6 years. As for primary tumor stage, 17 (58.6%) patients had stage ≥3, and distant metastasis was found in 10 (34.4%) patients. The mean time from transplantation to tumor detection was 13.7 years. The median disease-free survival was 11.0 months and the median overall survival (OS) was 18.1 months. In multivariate analysis of prognostic factors for OS, surgical resection was a positive prognostic factor (HR 1.357, p = 0.010) and the presence of distant metastasis at diagnosis was a negative prognostic factor (HR 1.047, p = 0.006). Conclusion: The behavior of colorectal cancer in posttransplant patients is more aggressive and refractory to treatment. A separate guideline for the colorectal screening program for the posttransplant patients needs to be established.

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