Clinical Implications of Basilar Artery Plaques in the Pontine Infarction with Normal Basilar Angiogram

A High-Resolution Magnetic Resonance Imaging Study

Han Jin Cho, Kyung Hye Kim, Eun Joo Kim, Tae Hong Lee, Sang Min Sung, Jihoe Heo, Dae Soo Jung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Using high-resolution magnetic resonance imaging (HR-MRI), we investigated the impact of basilar artery plaques that were not detected by magnetic resonance angiography (MRA) on the functional outcomes of patients with acute pontine infarction. Methods: A total of 40 patients with acute pontine infarction and normal basilar findings on MRA prospectively underwent HR-MRI for detection of basilar artery plaques. A relevant plaque was defined as one on the dorsal side of basilar artery, the same side of the ischemic lesion, and the same axial slices of the ischemic lesion. We analyzed the relationship between the relevant basilar artery plaques and the functional outcomes at 3 months. Results: The initial National Institutes of Health Stroke Scale score (3.5 versus 2.0, P =.012), and the incidences of neurological deterioration (42.9% versus 6.3%, P =.031) and unfavorable functional outcome (71.4% versus 12.5%, P =.001) were higher in patients with relevant basilar artery plaques than in those without. On multiple regression analysis, the relevant basilar artery plaque was a significant and independent predictor of unfavorable functional outcome (odds ratio, 6.662; 95% confidence interval, 1.117-39.735; P =.037). Conclusions: The presence of a relevant basilar artery plaque was closely related with unfavorable functional outcome in patients with acute pontine infarction even if the patients’ MRA showed normal basilar findings.

Original languageEnglish
Pages (from-to)3591-3598
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Volume27
Issue number12
DOIs
Publication statusPublished - 2018 Dec 1

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Basilar Artery
Infarction
Angiography
Magnetic Resonance Imaging
Magnetic Resonance Angiography
National Institutes of Health (U.S.)
Stroke
Odds Ratio
Regression Analysis
Confidence Intervals
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Clinical Implications of Basilar Artery Plaques in the Pontine Infarction with Normal Basilar Angiogram: A High-Resolution Magnetic Resonance Imaging Study",
abstract = "Background: Using high-resolution magnetic resonance imaging (HR-MRI), we investigated the impact of basilar artery plaques that were not detected by magnetic resonance angiography (MRA) on the functional outcomes of patients with acute pontine infarction. Methods: A total of 40 patients with acute pontine infarction and normal basilar findings on MRA prospectively underwent HR-MRI for detection of basilar artery plaques. A relevant plaque was defined as one on the dorsal side of basilar artery, the same side of the ischemic lesion, and the same axial slices of the ischemic lesion. We analyzed the relationship between the relevant basilar artery plaques and the functional outcomes at 3 months. Results: The initial National Institutes of Health Stroke Scale score (3.5 versus 2.0, P =.012), and the incidences of neurological deterioration (42.9{\%} versus 6.3{\%}, P =.031) and unfavorable functional outcome (71.4{\%} versus 12.5{\%}, P =.001) were higher in patients with relevant basilar artery plaques than in those without. On multiple regression analysis, the relevant basilar artery plaque was a significant and independent predictor of unfavorable functional outcome (odds ratio, 6.662; 95{\%} confidence interval, 1.117-39.735; P =.037). Conclusions: The presence of a relevant basilar artery plaque was closely related with unfavorable functional outcome in patients with acute pontine infarction even if the patients’ MRA showed normal basilar findings.",
author = "Cho, {Han Jin} and Kim, {Kyung Hye} and Kim, {Eun Joo} and Lee, {Tae Hong} and Sung, {Sang Min} and Jihoe Heo and Jung, {Dae Soo}",
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Clinical Implications of Basilar Artery Plaques in the Pontine Infarction with Normal Basilar Angiogram : A High-Resolution Magnetic Resonance Imaging Study. / Cho, Han Jin; Kim, Kyung Hye; Kim, Eun Joo; Lee, Tae Hong; Sung, Sang Min; Heo, Jihoe; Jung, Dae Soo.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 27, No. 12, 01.12.2018, p. 3591-3598.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical Implications of Basilar Artery Plaques in the Pontine Infarction with Normal Basilar Angiogram

T2 - A High-Resolution Magnetic Resonance Imaging Study

AU - Cho, Han Jin

AU - Kim, Kyung Hye

AU - Kim, Eun Joo

AU - Lee, Tae Hong

AU - Sung, Sang Min

AU - Heo, Jihoe

AU - Jung, Dae Soo

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Using high-resolution magnetic resonance imaging (HR-MRI), we investigated the impact of basilar artery plaques that were not detected by magnetic resonance angiography (MRA) on the functional outcomes of patients with acute pontine infarction. Methods: A total of 40 patients with acute pontine infarction and normal basilar findings on MRA prospectively underwent HR-MRI for detection of basilar artery plaques. A relevant plaque was defined as one on the dorsal side of basilar artery, the same side of the ischemic lesion, and the same axial slices of the ischemic lesion. We analyzed the relationship between the relevant basilar artery plaques and the functional outcomes at 3 months. Results: The initial National Institutes of Health Stroke Scale score (3.5 versus 2.0, P =.012), and the incidences of neurological deterioration (42.9% versus 6.3%, P =.031) and unfavorable functional outcome (71.4% versus 12.5%, P =.001) were higher in patients with relevant basilar artery plaques than in those without. On multiple regression analysis, the relevant basilar artery plaque was a significant and independent predictor of unfavorable functional outcome (odds ratio, 6.662; 95% confidence interval, 1.117-39.735; P =.037). Conclusions: The presence of a relevant basilar artery plaque was closely related with unfavorable functional outcome in patients with acute pontine infarction even if the patients’ MRA showed normal basilar findings.

AB - Background: Using high-resolution magnetic resonance imaging (HR-MRI), we investigated the impact of basilar artery plaques that were not detected by magnetic resonance angiography (MRA) on the functional outcomes of patients with acute pontine infarction. Methods: A total of 40 patients with acute pontine infarction and normal basilar findings on MRA prospectively underwent HR-MRI for detection of basilar artery plaques. A relevant plaque was defined as one on the dorsal side of basilar artery, the same side of the ischemic lesion, and the same axial slices of the ischemic lesion. We analyzed the relationship between the relevant basilar artery plaques and the functional outcomes at 3 months. Results: The initial National Institutes of Health Stroke Scale score (3.5 versus 2.0, P =.012), and the incidences of neurological deterioration (42.9% versus 6.3%, P =.031) and unfavorable functional outcome (71.4% versus 12.5%, P =.001) were higher in patients with relevant basilar artery plaques than in those without. On multiple regression analysis, the relevant basilar artery plaque was a significant and independent predictor of unfavorable functional outcome (odds ratio, 6.662; 95% confidence interval, 1.117-39.735; P =.037). Conclusions: The presence of a relevant basilar artery plaque was closely related with unfavorable functional outcome in patients with acute pontine infarction even if the patients’ MRA showed normal basilar findings.

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M3 - Article

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JO - Journal of Stroke and Cerebrovascular Diseases

JF - Journal of Stroke and Cerebrovascular Diseases

SN - 1052-3057

IS - 12

ER -