Clinical implications of young-onset pancreatic cancer patients after curative resection in Korea: a Korea Tumor Registry System Biliary Pancreas database analysis

Hyung S. Kim; Ho Seong Han; Woojin Kim; Changsoo Kim; Jin Young Jang; Wooil Kwon; Jin S. Heo; Sang H. Shin; Ho K. Hwang; Joon S. Park

doi:10.1016/j.hpb.2022.10.005

Clinical implications of young-onset pancreatic cancer patients after curative resection in Korea: a Korea Tumor Registry System Biliary Pancreas database analysis

Hyung S. Kim, Ho Seong Han, Woojin Kim, Changsoo Kim, Jin Young Jang, Wooil Kwon, Jin S. Heo, Sang H. Shin, Ho K. Hwang, Joon S. Park

Department of Preventive Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: This study evaluated the clinical characteristics and survival rate after curative resection of young age pancreatic cancer patients using Korea Tumor Registry System Biliary Pancreas (KOTUS-BP) Database analysis. Methods: We compared demographics and clinical outcomes in patients under the age of 50 years (young age group) and those over the age of 65 years (standard group) between 1991 and 2017. We estimated the survival curve using the Kaplan–Meier method and the hazard ratio using the Cox proportional hazard model and 1:4 propensity matching analysis. Results: A total of 2470 patients were analyzed, including 2091 in the standard group and 379 in the young age group. Survival analysis showed a better overall survival in the recently enrolled patients (2011–2017) in both the young age and standard groups (p = 0.001 and p = 0.005, respectively). Between 2011 and 2017, recurrence-free survival was shorter in the young age group (p = 0.02), but the overall survival was not significantly different between the two groups (p = 0.94). Conclusions: Young-onset pancreatic cancer patients had more advanced stages at the time of diagnosis; however, the overall survival of both the young age and standard groups was similar due to adjuvant treatment after operation.

Original language	English
Pages (from-to)	146-154
Number of pages	9
Journal	HPB
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.hpb.2022.10.005
Publication status	Published - 2023 Jan

Bibliographical note

Funding Information:
In Seok Choi M.D. Ph. D, Konyang University Hospital, choiins@kyuh.ac.kr. Sung-Sik Han, National Cancer Center, sshan@ncc.re.kr, Keun Soo Ahn, Keimyung University Dongsan Hospital, ahnksmd@gmail.com. Park Jae Woo, Daejeon St. Mary's Hospital, The Catholic University of Korea, jaewoo.gs@gmail.com. Jae-Woon Choi, Chungbuk National University College of Medicine, jwchoi@chungbuk.ac.kr. Hyeon Kook Lee, Ewha Womans University, leehk@ewha.ac.kr. Jae Hoon Lee, University of Ulsan College of Medicine and Asan Medical Center hbpsurgeon@gmail.com. Hyung Jun Kwon, Kyunpook National University Chilgolk Hospital, kwonhj95@knu.ac.kr. Kee Hwan Kim, Uijeongbu St. Mary's Hospital, The Catholic University of Korea keehwan@catholic.ac.kr. Yang Seok Koh, Chonnam National University Medical School, yskoh@jnu.ac.kr. Seong-Ryong Kim, Dongguk University Ilsan Hospital, ksrhbps7307@gmail.com. Young-dong Yu, Korea University College of Medicine, hust1351@naver.com. Jae Do Yang, Jeonbuk National University Hospital, yjd@jbnu.ac.kr. Seung Eun Lee, Chung-Ang University College of Medicine, selee508@cau.ac.kr. Chang-Sup Lim, Seoul National University Boramae Medical Center limcs7@gmail.com. Younghoon Roh, Dong-A University College of Medicine, gsryh@dau.ac.kr. Chi-Young Jeong, Gyeongsang national university, drjcy122@gmail.com.

Publisher Copyright:
© 2022 International Hepato-Pancreato-Biliary Association Inc.

All Science Journal Classification (ASJC) codes

Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.hpb.2022.10.005

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@article{8066dc045eea4299a504a64353e19d01,

title = "Clinical implications of young-onset pancreatic cancer patients after curative resection in Korea: a Korea Tumor Registry System Biliary Pancreas database analysis",

abstract = "Introduction: This study evaluated the clinical characteristics and survival rate after curative resection of young age pancreatic cancer patients using Korea Tumor Registry System Biliary Pancreas (KOTUS-BP) Database analysis. Methods: We compared demographics and clinical outcomes in patients under the age of 50 years (young age group) and those over the age of 65 years (standard group) between 1991 and 2017. We estimated the survival curve using the Kaplan–Meier method and the hazard ratio using the Cox proportional hazard model and 1:4 propensity matching analysis. Results: A total of 2470 patients were analyzed, including 2091 in the standard group and 379 in the young age group. Survival analysis showed a better overall survival in the recently enrolled patients (2011–2017) in both the young age and standard groups (p = 0.001 and p = 0.005, respectively). Between 2011 and 2017, recurrence-free survival was shorter in the young age group (p = 0.02), but the overall survival was not significantly different between the two groups (p = 0.94). Conclusions: Young-onset pancreatic cancer patients had more advanced stages at the time of diagnosis; however, the overall survival of both the young age and standard groups was similar due to adjuvant treatment after operation.",

author = "Kim, {Hyung S.} and Han, {Ho Seong} and Woojin Kim and Changsoo Kim and Jang, {Jin Young} and Wooil Kwon and Heo, {Jin S.} and Shin, {Sang H.} and Hwang, {Ho K.} and Park, {Joon S.}",

note = "Funding Information: In Seok Choi M.D. Ph. D, Konyang University Hospital, choiins@kyuh.ac.kr. Sung-Sik Han, National Cancer Center, sshan@ncc.re.kr, Keun Soo Ahn, Keimyung University Dongsan Hospital, ahnksmd@gmail.com. Park Jae Woo, Daejeon St. Mary's Hospital, The Catholic University of Korea, jaewoo.gs@gmail.com. Jae-Woon Choi, Chungbuk National University College of Medicine, jwchoi@chungbuk.ac.kr. Hyeon Kook Lee, Ewha Womans University, leehk@ewha.ac.kr. Jae Hoon Lee, University of Ulsan College of Medicine and Asan Medical Center hbpsurgeon@gmail.com. Hyung Jun Kwon, Kyunpook National University Chilgolk Hospital, kwonhj95@knu.ac.kr. Kee Hwan Kim, Uijeongbu St. Mary's Hospital, The Catholic University of Korea keehwan@catholic.ac.kr. Yang Seok Koh, Chonnam National University Medical School, yskoh@jnu.ac.kr. Seong-Ryong Kim, Dongguk University Ilsan Hospital, ksrhbps7307@gmail.com. Young-dong Yu, Korea University College of Medicine, hust1351@naver.com. Jae Do Yang, Jeonbuk National University Hospital, yjd@jbnu.ac.kr. Seung Eun Lee, Chung-Ang University College of Medicine, selee508@cau.ac.kr. Chang-Sup Lim, Seoul National University Boramae Medical Center limcs7@gmail.com. Younghoon Roh, Dong-A University College of Medicine, gsryh@dau.ac.kr. Chi-Young Jeong, Gyeongsang national university, drjcy122@gmail.com. Publisher Copyright: {\textcopyright} 2022 International Hepato-Pancreato-Biliary Association Inc.",

year = "2023",

month = jan,

doi = "10.1016/j.hpb.2022.10.005",

language = "English",

volume = "25",

pages = "146--154",

journal = "HPB",

issn = "1365-182X",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Clinical implications of young-onset pancreatic cancer patients after curative resection in Korea

T2 - a Korea Tumor Registry System Biliary Pancreas database analysis

AU - Kim, Hyung S.

AU - Han, Ho Seong

AU - Kim, Woojin

AU - Kim, Changsoo

AU - Jang, Jin Young

AU - Kwon, Wooil

AU - Heo, Jin S.

AU - Shin, Sang H.

AU - Hwang, Ho K.

AU - Park, Joon S.

N1 - Funding Information: In Seok Choi M.D. Ph. D, Konyang University Hospital, choiins@kyuh.ac.kr. Sung-Sik Han, National Cancer Center, sshan@ncc.re.kr, Keun Soo Ahn, Keimyung University Dongsan Hospital, ahnksmd@gmail.com. Park Jae Woo, Daejeon St. Mary's Hospital, The Catholic University of Korea, jaewoo.gs@gmail.com. Jae-Woon Choi, Chungbuk National University College of Medicine, jwchoi@chungbuk.ac.kr. Hyeon Kook Lee, Ewha Womans University, leehk@ewha.ac.kr. Jae Hoon Lee, University of Ulsan College of Medicine and Asan Medical Center hbpsurgeon@gmail.com. Hyung Jun Kwon, Kyunpook National University Chilgolk Hospital, kwonhj95@knu.ac.kr. Kee Hwan Kim, Uijeongbu St. Mary's Hospital, The Catholic University of Korea keehwan@catholic.ac.kr. Yang Seok Koh, Chonnam National University Medical School, yskoh@jnu.ac.kr. Seong-Ryong Kim, Dongguk University Ilsan Hospital, ksrhbps7307@gmail.com. Young-dong Yu, Korea University College of Medicine, hust1351@naver.com. Jae Do Yang, Jeonbuk National University Hospital, yjd@jbnu.ac.kr. Seung Eun Lee, Chung-Ang University College of Medicine, selee508@cau.ac.kr. Chang-Sup Lim, Seoul National University Boramae Medical Center limcs7@gmail.com. Younghoon Roh, Dong-A University College of Medicine, gsryh@dau.ac.kr. Chi-Young Jeong, Gyeongsang national university, drjcy122@gmail.com. Publisher Copyright: © 2022 International Hepato-Pancreato-Biliary Association Inc.

PY - 2023/1

Y1 - 2023/1

N2 - Introduction: This study evaluated the clinical characteristics and survival rate after curative resection of young age pancreatic cancer patients using Korea Tumor Registry System Biliary Pancreas (KOTUS-BP) Database analysis. Methods: We compared demographics and clinical outcomes in patients under the age of 50 years (young age group) and those over the age of 65 years (standard group) between 1991 and 2017. We estimated the survival curve using the Kaplan–Meier method and the hazard ratio using the Cox proportional hazard model and 1:4 propensity matching analysis. Results: A total of 2470 patients were analyzed, including 2091 in the standard group and 379 in the young age group. Survival analysis showed a better overall survival in the recently enrolled patients (2011–2017) in both the young age and standard groups (p = 0.001 and p = 0.005, respectively). Between 2011 and 2017, recurrence-free survival was shorter in the young age group (p = 0.02), but the overall survival was not significantly different between the two groups (p = 0.94). Conclusions: Young-onset pancreatic cancer patients had more advanced stages at the time of diagnosis; however, the overall survival of both the young age and standard groups was similar due to adjuvant treatment after operation.

AB - Introduction: This study evaluated the clinical characteristics and survival rate after curative resection of young age pancreatic cancer patients using Korea Tumor Registry System Biliary Pancreas (KOTUS-BP) Database analysis. Methods: We compared demographics and clinical outcomes in patients under the age of 50 years (young age group) and those over the age of 65 years (standard group) between 1991 and 2017. We estimated the survival curve using the Kaplan–Meier method and the hazard ratio using the Cox proportional hazard model and 1:4 propensity matching analysis. Results: A total of 2470 patients were analyzed, including 2091 in the standard group and 379 in the young age group. Survival analysis showed a better overall survival in the recently enrolled patients (2011–2017) in both the young age and standard groups (p = 0.001 and p = 0.005, respectively). Between 2011 and 2017, recurrence-free survival was shorter in the young age group (p = 0.02), but the overall survival was not significantly different between the two groups (p = 0.94). Conclusions: Young-onset pancreatic cancer patients had more advanced stages at the time of diagnosis; however, the overall survival of both the young age and standard groups was similar due to adjuvant treatment after operation.

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UR - http://www.scopus.com/inward/citedby.url?scp=85147119933&partnerID=8YFLogxK

U2 - 10.1016/j.hpb.2022.10.005

DO - 10.1016/j.hpb.2022.10.005

M3 - Article

AN - SCOPUS:85147119933

SN - 1365-182X

VL - 25

SP - 146

EP - 154

JO - HPB

JF - HPB

IS - 1

ER -

Clinical implications of young-onset pancreatic cancer patients after curative resection in Korea: a Korea Tumor Registry System Biliary Pancreas database analysis

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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