Clinical outcome of renal transplantation in patients with positive pre-transplant hepatitis B surface antigen

Joon Ahn Hyung, Soo Kim Myoung, Seun Kim Yu, Il Kim Soon, Ha Huh Kyu, Ki Ju Man, Hoon Ahn Sang, Kwang Hyub Han

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44 Citations (Scopus)

Abstract

The clinical outcomes of 2,054 renal recipients were examined retrospectively based on pretransplant hepatitis B surface antigen (HBsAg) status to investigate the efficacy of lamivudine treatment in HBsAg positive recipients. Pretransplant HBsAg positivity was documented in 66 recipients. The 10-year patient and graft survival rates in Ag positive group were significantly lower than those of Ag negative group (64.4/36.6% vs. 88.2/70.5%, respectively, P < 0.0001). Since 1997, lamivudine was used when hepatitis B virus polymerase chain reaction (HBV PCR) was positive or when the level of posttransplant viral load rose. Lamivudine given to 27 recipients markedly improved both 10-year patient and graft survivals compared to Ag positive renal recipients who did not take lamivudine (85.3/59.2% vs. 49.9/22.7%, respectively, P < 0.0001). Overall, 13 viral breakthroughs among 24 lamivudine-responsive patients were observed. The cumulative incidence of viral breakthrough at 60 months was 53.3%. Adefovir rescue in three viral breakthroughs patients induces virological response and restoration of liver function. In 10 patients who did not changed to adefovir, 6 patients are alive with elevated liver enzymes. In conclusion, in the era of lamivudine and adefovir, renal transplantation in HBsAg positive end-stage renal disease patients should not be abandoned.

Original languageEnglish
Pages (from-to)1655-1663
Number of pages9
JournalJournal of Medical Virology
Volume79
Issue number11
DOIs
Publication statusPublished - 2007 Nov

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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