Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients

Hee Ji Han, Ju Ree Kim, Hee Rim Nam, Ki Chang Keum, Chang Ok Suh, Yong Bae Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. Materials and Methods: From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. Results: The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively. Conclusion: In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalRadiation Oncology Journal
Volume32
Issue number3
DOIs
Publication statusPublished - 2014 Sep 1

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Sentinel Lymph Node Biopsy
Breast Neoplasms
Disease-Free Survival
Lymph Nodes
Recurrence
Neoplasm Metastasis
Segmental Mastectomy
Lymph Node Excision
Treatment Failure
Radiotherapy
Multivariate Analysis
Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

@article{1de18fdec2264d40b1db3889e82bb2cb,
title = "Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients",
abstract = "Purpose: To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. Materials and Methods: From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. Results: The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7{\%}, and the overall false negative rate (FNR) was 5.3{\%}. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9{\%}, 1.9{\%}, and 2.8{\%} of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100{\%}, 96.8{\%}, and 98.1{\%}, respectively. Conclusion: In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.",
author = "Han, {Hee Ji} and Kim, {Ju Ree} and Nam, {Hee Rim} and Keum, {Ki Chang} and Suh, {Chang Ok} and Kim, {Yong Bae}",
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Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients. / Han, Hee Ji; Kim, Ju Ree; Nam, Hee Rim; Keum, Ki Chang; Suh, Chang Ok; Kim, Yong Bae.

In: Radiation Oncology Journal, Vol. 32, No. 3, 01.09.2014, p. 132-137.

Research output: Contribution to journalArticle

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T1 - Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients

AU - Han, Hee Ji

AU - Kim, Ju Ree

AU - Nam, Hee Rim

AU - Keum, Ki Chang

AU - Suh, Chang Ok

AU - Kim, Yong Bae

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N2 - Purpose: To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. Materials and Methods: From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. Results: The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively. Conclusion: In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.

AB - Purpose: To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. Materials and Methods: From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. Results: The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively. Conclusion: In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.

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