Abstract
Background and Aims: Both clinical outcomes and factors predictive for poor response after an initial course of corticosteroids have not yet been well established in the treatment of moderate to severe ulcerative colitis (UC). We therefore evaluated the short- and long-term effects of corticosteroids and prognostic factors in UC patients after such therapy. Methods: We recruited consecutive patients who had moderate to severe UC and were treated with the first course of systemic corticosteroids between November 1996 and December 2007 using the database of Severance Hospital in Seoul, Korea. We then evaluated clinical outcomes at 1month, 3months, and 1year after the initiation of corticosteroid treatment. Results: Our study included a total of 177 patients. At 1month, complete remission was achieved in 70 patients (39.5%) and partial remission in 88 (49.7%). Fifteen patients (8.5%) were refractory to the treatment, and four (2.3%) underwent proctocolectomy. We observed prolonged response in 111 (64.9%) at 3months and 95 (59.4%) patients at 1year, corticosteroid dependency in 49 (28.7%) and 51 (31.9%) patients, and no response in 11 (6.4%) and 14 (8.7%) patients. A higher initial Mayo score was found to be the only poor prognostic factor at 1month (P=0.032) and 1year (P<0.001). Conclusions: Our data showed that most Korean patients with active UC responded well to the first course of corticosteroid treatment. However, a considerable number of patients eventually turned out to be refractory to or dependent on this therapy. The initial higher Mayo score was strongly associated with poor outcomes.
| Original language | English |
|---|---|
| Pages (from-to) | 1114-1122 |
| Number of pages | 9 |
| Journal | Journal of Gastroenterology and Hepatology (Australia) |
| Volume | 26 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2011 Jul |
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All Science Journal Classification (ASJC) codes
- Hepatology
- Gastroenterology
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Clinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis. / Yoon, Jin Young; Cheon, Jae Hee; Park, Jae Jun; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho.
In: Journal of Gastroenterology and Hepatology (Australia), Vol. 26, No. 7, 07.2011, p. 1114-1122.Research output: Contribution to journal › Article
TY - JOUR
T1 - Clinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis
AU - Yoon, Jin Young
AU - Cheon, Jae Hee
AU - Park, Jae Jun
AU - Hong, Sung Pil
AU - Kim, Tae Il
AU - Kim, Won Ho
PY - 2011/7
Y1 - 2011/7
N2 - Background and Aims: Both clinical outcomes and factors predictive for poor response after an initial course of corticosteroids have not yet been well established in the treatment of moderate to severe ulcerative colitis (UC). We therefore evaluated the short- and long-term effects of corticosteroids and prognostic factors in UC patients after such therapy. Methods: We recruited consecutive patients who had moderate to severe UC and were treated with the first course of systemic corticosteroids between November 1996 and December 2007 using the database of Severance Hospital in Seoul, Korea. We then evaluated clinical outcomes at 1month, 3months, and 1year after the initiation of corticosteroid treatment. Results: Our study included a total of 177 patients. At 1month, complete remission was achieved in 70 patients (39.5%) and partial remission in 88 (49.7%). Fifteen patients (8.5%) were refractory to the treatment, and four (2.3%) underwent proctocolectomy. We observed prolonged response in 111 (64.9%) at 3months and 95 (59.4%) patients at 1year, corticosteroid dependency in 49 (28.7%) and 51 (31.9%) patients, and no response in 11 (6.4%) and 14 (8.7%) patients. A higher initial Mayo score was found to be the only poor prognostic factor at 1month (P=0.032) and 1year (P<0.001). Conclusions: Our data showed that most Korean patients with active UC responded well to the first course of corticosteroid treatment. However, a considerable number of patients eventually turned out to be refractory to or dependent on this therapy. The initial higher Mayo score was strongly associated with poor outcomes.
AB - Background and Aims: Both clinical outcomes and factors predictive for poor response after an initial course of corticosteroids have not yet been well established in the treatment of moderate to severe ulcerative colitis (UC). We therefore evaluated the short- and long-term effects of corticosteroids and prognostic factors in UC patients after such therapy. Methods: We recruited consecutive patients who had moderate to severe UC and were treated with the first course of systemic corticosteroids between November 1996 and December 2007 using the database of Severance Hospital in Seoul, Korea. We then evaluated clinical outcomes at 1month, 3months, and 1year after the initiation of corticosteroid treatment. Results: Our study included a total of 177 patients. At 1month, complete remission was achieved in 70 patients (39.5%) and partial remission in 88 (49.7%). Fifteen patients (8.5%) were refractory to the treatment, and four (2.3%) underwent proctocolectomy. We observed prolonged response in 111 (64.9%) at 3months and 95 (59.4%) patients at 1year, corticosteroid dependency in 49 (28.7%) and 51 (31.9%) patients, and no response in 11 (6.4%) and 14 (8.7%) patients. A higher initial Mayo score was found to be the only poor prognostic factor at 1month (P=0.032) and 1year (P<0.001). Conclusions: Our data showed that most Korean patients with active UC responded well to the first course of corticosteroid treatment. However, a considerable number of patients eventually turned out to be refractory to or dependent on this therapy. The initial higher Mayo score was strongly associated with poor outcomes.
UR - http://www.scopus.com/inward/record.url?scp=79958826408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958826408&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1746.2011.06688.x
DO - 10.1111/j.1440-1746.2011.06688.x
M3 - Article
C2 - 21299620
AN - SCOPUS:79958826408
VL - 26
SP - 1114
EP - 1122
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 7
ER -