Clinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis

Jin Young Yoon, Jae Hee Cheon, Jae Jun Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim

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15 Citations (Scopus)

Abstract

Background and Aims: Both clinical outcomes and factors predictive for poor response after an initial course of corticosteroids have not yet been well established in the treatment of moderate to severe ulcerative colitis (UC). We therefore evaluated the short- and long-term effects of corticosteroids and prognostic factors in UC patients after such therapy. Methods: We recruited consecutive patients who had moderate to severe UC and were treated with the first course of systemic corticosteroids between November 1996 and December 2007 using the database of Severance Hospital in Seoul, Korea. We then evaluated clinical outcomes at 1month, 3months, and 1year after the initiation of corticosteroid treatment. Results: Our study included a total of 177 patients. At 1month, complete remission was achieved in 70 patients (39.5%) and partial remission in 88 (49.7%). Fifteen patients (8.5%) were refractory to the treatment, and four (2.3%) underwent proctocolectomy. We observed prolonged response in 111 (64.9%) at 3months and 95 (59.4%) patients at 1year, corticosteroid dependency in 49 (28.7%) and 51 (31.9%) patients, and no response in 11 (6.4%) and 14 (8.7%) patients. A higher initial Mayo score was found to be the only poor prognostic factor at 1month (P=0.032) and 1year (P<0.001). Conclusions: Our data showed that most Korean patients with active UC responded well to the first course of corticosteroid treatment. However, a considerable number of patients eventually turned out to be refractory to or dependent on this therapy. The initial higher Mayo score was strongly associated with poor outcomes.

Original languageEnglish
Pages (from-to)1114-1122
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number7
DOIs
Publication statusPublished - 2011 Jul

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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