Clinical outcomes and factors related to resectability and curability of EMR for early colorectal cancer

Jae Jun Park, JaeHee Cheon, Ji Eun Kwon, Jae Kook Shin, Soung Min Jeon, Hyun Jung Bok, Jin Ha Lee, Chang Mo Moon, Sung Pil Hong, Tae Il Kim, Hoguen Kim, Won Ho Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: EMR has emerged as an alternative therapeutic option for selected cases of early colorectal cancer (ECC). However, the factors associated with resectability and curability of EMR for ECC remain unknown. Objective: To investigate clinical outcomes and factors related to resectability and curability in ECC cases treated with EMR. Design: Retrospective study. Setting: Tertiary-care academic medical center. Patients: This study involved all patients in whom EMR was performed for ECC at Severance Hospital between March 1997 and August 2007. A total of 236 cases of ECC occurring in 231 patients (66.2% men) were enrolled. Intervention: EMR. Curative surgical resection and lymph node dissection were used in cases that were incompletely cured by EMR. Main Outcome Measurements: Resectability, curability, and recurrence. Results: Complete cure was achieved for 162 lesions (68.6%). Of the remaining 74 cases (31.4%), 69 (29.2%) were incompletely cured, and the other 5 (2.1%) had an undetermined resection status and ultimately required supplementary surgical resection for curative treatment. Location on the right side of the colon, piecemeal resection, and submucosal carcinoma were independently associated with incomplete resection, whereas depressed tumor type was independently related to incomplete cure. Among the ECC cases completely cured by EMR and followed for more than a year (n = 118), local recurrence was observed in one case (0.8%) during the median follow-up period of 39.4 months (range 12.4-123.1 months). Limitations: Single-center, retrospective study. Conclusion: Our data show that EMR is feasible and could be an effective option for treatment of ECC if the technique is applied with the appropriate indications.

Original languageEnglish
Pages (from-to)1337-1346
Number of pages10
JournalGastrointestinal Endoscopy
Volume74
Issue number6
DOIs
Publication statusPublished - 2011 Dec 1

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Colorectal Neoplasms
Retrospective Studies
Recurrence
Tertiary Healthcare
Lymph Node Excision
Colon
Therapeutics
Carcinoma
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Park, Jae Jun ; Cheon, JaeHee ; Kwon, Ji Eun ; Shin, Jae Kook ; Jeon, Soung Min ; Bok, Hyun Jung ; Lee, Jin Ha ; Moon, Chang Mo ; Hong, Sung Pil ; Kim, Tae Il ; Kim, Hoguen ; Kim, Won Ho. / Clinical outcomes and factors related to resectability and curability of EMR for early colorectal cancer. In: Gastrointestinal Endoscopy. 2011 ; Vol. 74, No. 6. pp. 1337-1346.
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title = "Clinical outcomes and factors related to resectability and curability of EMR for early colorectal cancer",
abstract = "Background: EMR has emerged as an alternative therapeutic option for selected cases of early colorectal cancer (ECC). However, the factors associated with resectability and curability of EMR for ECC remain unknown. Objective: To investigate clinical outcomes and factors related to resectability and curability in ECC cases treated with EMR. Design: Retrospective study. Setting: Tertiary-care academic medical center. Patients: This study involved all patients in whom EMR was performed for ECC at Severance Hospital between March 1997 and August 2007. A total of 236 cases of ECC occurring in 231 patients (66.2{\%} men) were enrolled. Intervention: EMR. Curative surgical resection and lymph node dissection were used in cases that were incompletely cured by EMR. Main Outcome Measurements: Resectability, curability, and recurrence. Results: Complete cure was achieved for 162 lesions (68.6{\%}). Of the remaining 74 cases (31.4{\%}), 69 (29.2{\%}) were incompletely cured, and the other 5 (2.1{\%}) had an undetermined resection status and ultimately required supplementary surgical resection for curative treatment. Location on the right side of the colon, piecemeal resection, and submucosal carcinoma were independently associated with incomplete resection, whereas depressed tumor type was independently related to incomplete cure. Among the ECC cases completely cured by EMR and followed for more than a year (n = 118), local recurrence was observed in one case (0.8{\%}) during the median follow-up period of 39.4 months (range 12.4-123.1 months). Limitations: Single-center, retrospective study. Conclusion: Our data show that EMR is feasible and could be an effective option for treatment of ECC if the technique is applied with the appropriate indications.",
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Park, JJ, Cheon, J, Kwon, JE, Shin, JK, Jeon, SM, Bok, HJ, Lee, JH, Moon, CM, Hong, SP, Kim, TI, Kim, H & Kim, WH 2011, 'Clinical outcomes and factors related to resectability and curability of EMR for early colorectal cancer', Gastrointestinal Endoscopy, vol. 74, no. 6, pp. 1337-1346. https://doi.org/10.1016/j.gie.2011.07.069

Clinical outcomes and factors related to resectability and curability of EMR for early colorectal cancer. / Park, Jae Jun; Cheon, JaeHee; Kwon, Ji Eun; Shin, Jae Kook; Jeon, Soung Min; Bok, Hyun Jung; Lee, Jin Ha; Moon, Chang Mo; Hong, Sung Pil; Kim, Tae Il; Kim, Hoguen; Kim, Won Ho.

In: Gastrointestinal Endoscopy, Vol. 74, No. 6, 01.12.2011, p. 1337-1346.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical outcomes and factors related to resectability and curability of EMR for early colorectal cancer

AU - Park, Jae Jun

AU - Cheon, JaeHee

AU - Kwon, Ji Eun

AU - Shin, Jae Kook

AU - Jeon, Soung Min

AU - Bok, Hyun Jung

AU - Lee, Jin Ha

AU - Moon, Chang Mo

AU - Hong, Sung Pil

AU - Kim, Tae Il

AU - Kim, Hoguen

AU - Kim, Won Ho

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background: EMR has emerged as an alternative therapeutic option for selected cases of early colorectal cancer (ECC). However, the factors associated with resectability and curability of EMR for ECC remain unknown. Objective: To investigate clinical outcomes and factors related to resectability and curability in ECC cases treated with EMR. Design: Retrospective study. Setting: Tertiary-care academic medical center. Patients: This study involved all patients in whom EMR was performed for ECC at Severance Hospital between March 1997 and August 2007. A total of 236 cases of ECC occurring in 231 patients (66.2% men) were enrolled. Intervention: EMR. Curative surgical resection and lymph node dissection were used in cases that were incompletely cured by EMR. Main Outcome Measurements: Resectability, curability, and recurrence. Results: Complete cure was achieved for 162 lesions (68.6%). Of the remaining 74 cases (31.4%), 69 (29.2%) were incompletely cured, and the other 5 (2.1%) had an undetermined resection status and ultimately required supplementary surgical resection for curative treatment. Location on the right side of the colon, piecemeal resection, and submucosal carcinoma were independently associated with incomplete resection, whereas depressed tumor type was independently related to incomplete cure. Among the ECC cases completely cured by EMR and followed for more than a year (n = 118), local recurrence was observed in one case (0.8%) during the median follow-up period of 39.4 months (range 12.4-123.1 months). Limitations: Single-center, retrospective study. Conclusion: Our data show that EMR is feasible and could be an effective option for treatment of ECC if the technique is applied with the appropriate indications.

AB - Background: EMR has emerged as an alternative therapeutic option for selected cases of early colorectal cancer (ECC). However, the factors associated with resectability and curability of EMR for ECC remain unknown. Objective: To investigate clinical outcomes and factors related to resectability and curability in ECC cases treated with EMR. Design: Retrospective study. Setting: Tertiary-care academic medical center. Patients: This study involved all patients in whom EMR was performed for ECC at Severance Hospital between March 1997 and August 2007. A total of 236 cases of ECC occurring in 231 patients (66.2% men) were enrolled. Intervention: EMR. Curative surgical resection and lymph node dissection were used in cases that were incompletely cured by EMR. Main Outcome Measurements: Resectability, curability, and recurrence. Results: Complete cure was achieved for 162 lesions (68.6%). Of the remaining 74 cases (31.4%), 69 (29.2%) were incompletely cured, and the other 5 (2.1%) had an undetermined resection status and ultimately required supplementary surgical resection for curative treatment. Location on the right side of the colon, piecemeal resection, and submucosal carcinoma were independently associated with incomplete resection, whereas depressed tumor type was independently related to incomplete cure. Among the ECC cases completely cured by EMR and followed for more than a year (n = 118), local recurrence was observed in one case (0.8%) during the median follow-up period of 39.4 months (range 12.4-123.1 months). Limitations: Single-center, retrospective study. Conclusion: Our data show that EMR is feasible and could be an effective option for treatment of ECC if the technique is applied with the appropriate indications.

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