Clinical outcomes and therapeutic strategy in patients with acute myocardial infarction according to renal function - Data from the Korean Acute Myocardial Infarction Registry

Sang Hee Lee, Young Jo Kim, Woong Kim, Jong Seon Park, Dong Gu Shin, Seung Ho Hur, Chong Jin Kim, Myeong Chan Cho, Shung Chull Chae, Myung Ho Jeong, Taek Jong Hong, Doo Il Kim, Kee Sik Kim, Bon Kwon Koo, Byung Ok Kim, Chong Yun Rhim, Donghoon Choi, Dong Kyu Jin, Hyeon Cheol Gwon, In Ho Chae & 29 others In Whan Seong, Jae Young Rhew, Jang Ho Bae, Jei Keon Chae, Jeong Gwan Cho, Jin Man Cho, Jin Yong Hwang, Jong Hyun Kim, Junghan Yoon, Ju Young Yang, Keum Soo Park, Ki Bae Seung, Kyoo Rok Han, Kyoung Tae Jeong, Moo Hyun Kim, Myoung Yong Lee, Nae Hee Lee, Seok Kyu Oh, Seong Wook Park, Seong Woon Rha, Seung Jae Joo, Seung Jea Tahk, Seung Jung Park, Soo Joong Kim, Tae Hoon Ahn, Yangsoo Jang, Young Keun Ahn, Young Youp Koh, Wook Sung Chung

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: The aim of the present study was to evaluate the relationship between clinical outcomes after acute myocardial infarction (MI) and renal function by glomerular filtration rate (GFR) in patients with normal or mildly elevated serum creatinine concentrations. Methods and Results: As part of the Korean Acute Myocardial Infarction Registry (KAMIR), 6,834 acute MI patients with a serum creatinine concentration of ≤2.0 mg/dl were enrolled from November 2005 to December 2006. The renal function was stratified arbitrary to 5 groups: (1) normal function, >90.0; (2) preserved function, 75.0-89.9; (3) mild dysfunction, 60.0-74.9; (4) moderate dysfunction, 45.0-59.9; (5) severe dysfunction, <45ml·min-1·;1.73m-2. Clinical characteristics, mortality and adverse events were analyzed among each group. Although reperfusion and medical therapies were underused, the rates of mortality and adverse events were increased with declining renal function. After adjustment with confounders, severe and moderate renal dysfunctions were important risk predictors of in-hospital mortality, long-term mortality and adverse events. Conclusion: The spectrum of renal function, when it was presented by GFR, is broad and is an important risk predictor for adverse outcomes after acute MI, even in patients with normal or mildly elevated serum creatinine concentrations. Furthermore, standard treatments were underused in any degree of renal dysfunction.

Original languageEnglish
Pages (from-to)1410-1418
Number of pages9
JournalCirculation Journal
Volume72
Issue number9
DOIs
Publication statusPublished - 2008 Sep 3

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Registries
Myocardial Infarction
Kidney
Creatinine
Glomerular Filtration Rate
Mortality
Therapeutics
Serum
Hospital Mortality
Reperfusion

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, Sang Hee ; Kim, Young Jo ; Kim, Woong ; Park, Jong Seon ; Shin, Dong Gu ; Hur, Seung Ho ; Kim, Chong Jin ; Cho, Myeong Chan ; Chae, Shung Chull ; Jeong, Myung Ho ; Hong, Taek Jong ; Kim, Doo Il ; Kim, Kee Sik ; Koo, Bon Kwon ; Kim, Byung Ok ; Rhim, Chong Yun ; Choi, Donghoon ; Jin, Dong Kyu ; Gwon, Hyeon Cheol ; Chae, In Ho ; Seong, In Whan ; Rhew, Jae Young ; Bae, Jang Ho ; Chae, Jei Keon ; Cho, Jeong Gwan ; Cho, Jin Man ; Hwang, Jin Yong ; Kim, Jong Hyun ; Yoon, Junghan ; Yang, Ju Young ; Park, Keum Soo ; Seung, Ki Bae ; Han, Kyoo Rok ; Jeong, Kyoung Tae ; Kim, Moo Hyun ; Lee, Myoung Yong ; Lee, Nae Hee ; Oh, Seok Kyu ; Park, Seong Wook ; Rha, Seong Woon ; Joo, Seung Jae ; Tahk, Seung Jea ; Park, Seung Jung ; Kim, Soo Joong ; Ahn, Tae Hoon ; Jang, Yangsoo ; Ahn, Young Keun ; Koh, Young Youp ; Chung, Wook Sung. / Clinical outcomes and therapeutic strategy in patients with acute myocardial infarction according to renal function - Data from the Korean Acute Myocardial Infarction Registry. In: Circulation Journal. 2008 ; Vol. 72, No. 9. pp. 1410-1418.
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title = "Clinical outcomes and therapeutic strategy in patients with acute myocardial infarction according to renal function - Data from the Korean Acute Myocardial Infarction Registry",
abstract = "Background: The aim of the present study was to evaluate the relationship between clinical outcomes after acute myocardial infarction (MI) and renal function by glomerular filtration rate (GFR) in patients with normal or mildly elevated serum creatinine concentrations. Methods and Results: As part of the Korean Acute Myocardial Infarction Registry (KAMIR), 6,834 acute MI patients with a serum creatinine concentration of ≤2.0 mg/dl were enrolled from November 2005 to December 2006. The renal function was stratified arbitrary to 5 groups: (1) normal function, >90.0; (2) preserved function, 75.0-89.9; (3) mild dysfunction, 60.0-74.9; (4) moderate dysfunction, 45.0-59.9; (5) severe dysfunction, <45ml·min-1·;1.73m-2. Clinical characteristics, mortality and adverse events were analyzed among each group. Although reperfusion and medical therapies were underused, the rates of mortality and adverse events were increased with declining renal function. After adjustment with confounders, severe and moderate renal dysfunctions were important risk predictors of in-hospital mortality, long-term mortality and adverse events. Conclusion: The spectrum of renal function, when it was presented by GFR, is broad and is an important risk predictor for adverse outcomes after acute MI, even in patients with normal or mildly elevated serum creatinine concentrations. Furthermore, standard treatments were underused in any degree of renal dysfunction.",
author = "Lee, {Sang Hee} and Kim, {Young Jo} and Woong Kim and Park, {Jong Seon} and Shin, {Dong Gu} and Hur, {Seung Ho} and Kim, {Chong Jin} and Cho, {Myeong Chan} and Chae, {Shung Chull} and Jeong, {Myung Ho} and Hong, {Taek Jong} and Kim, {Doo Il} and Kim, {Kee Sik} and Koo, {Bon Kwon} and Kim, {Byung Ok} and Rhim, {Chong Yun} and Donghoon Choi and Jin, {Dong Kyu} and Gwon, {Hyeon Cheol} and Chae, {In Ho} and Seong, {In Whan} and Rhew, {Jae Young} and Bae, {Jang Ho} and Chae, {Jei Keon} and Cho, {Jeong Gwan} and Cho, {Jin Man} and Hwang, {Jin Yong} and Kim, {Jong Hyun} and Junghan Yoon and Yang, {Ju Young} and Park, {Keum Soo} and Seung, {Ki Bae} and Han, {Kyoo Rok} and Jeong, {Kyoung Tae} and Kim, {Moo Hyun} and Lee, {Myoung Yong} and Lee, {Nae Hee} and Oh, {Seok Kyu} and Park, {Seong Wook} and Rha, {Seong Woon} and Joo, {Seung Jae} and Tahk, {Seung Jea} and Park, {Seung Jung} and Kim, {Soo Joong} and Ahn, {Tae Hoon} and Yangsoo Jang and Ahn, {Young Keun} and Koh, {Young Youp} and Chung, {Wook Sung}",
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Lee, SH, Kim, YJ, Kim, W, Park, JS, Shin, DG, Hur, SH, Kim, CJ, Cho, MC, Chae, SC, Jeong, MH, Hong, TJ, Kim, DI, Kim, KS, Koo, BK, Kim, BO, Rhim, CY, Choi, D, Jin, DK, Gwon, HC, Chae, IH, Seong, IW, Rhew, JY, Bae, JH, Chae, JK, Cho, JG, Cho, JM, Hwang, JY, Kim, JH, Yoon, J, Yang, JY, Park, KS, Seung, KB, Han, KR, Jeong, KT, Kim, MH, Lee, MY, Lee, NH, Oh, SK, Park, SW, Rha, SW, Joo, SJ, Tahk, SJ, Park, SJ, Kim, SJ, Ahn, TH, Jang, Y, Ahn, YK, Koh, YY & Chung, WS 2008, 'Clinical outcomes and therapeutic strategy in patients with acute myocardial infarction according to renal function - Data from the Korean Acute Myocardial Infarction Registry', Circulation Journal, vol. 72, no. 9, pp. 1410-1418. https://doi.org/10.1253/circj.CJ-08-0088

Clinical outcomes and therapeutic strategy in patients with acute myocardial infarction according to renal function - Data from the Korean Acute Myocardial Infarction Registry. / Lee, Sang Hee; Kim, Young Jo; Kim, Woong; Park, Jong Seon; Shin, Dong Gu; Hur, Seung Ho; Kim, Chong Jin; Cho, Myeong Chan; Chae, Shung Chull; Jeong, Myung Ho; Hong, Taek Jong; Kim, Doo Il; Kim, Kee Sik; Koo, Bon Kwon; Kim, Byung Ok; Rhim, Chong Yun; Choi, Donghoon; Jin, Dong Kyu; Gwon, Hyeon Cheol; Chae, In Ho; Seong, In Whan; Rhew, Jae Young; Bae, Jang Ho; Chae, Jei Keon; Cho, Jeong Gwan; Cho, Jin Man; Hwang, Jin Yong; Kim, Jong Hyun; Yoon, Junghan; Yang, Ju Young; Park, Keum Soo; Seung, Ki Bae; Han, Kyoo Rok; Jeong, Kyoung Tae; Kim, Moo Hyun; Lee, Myoung Yong; Lee, Nae Hee; Oh, Seok Kyu; Park, Seong Wook; Rha, Seong Woon; Joo, Seung Jae; Tahk, Seung Jea; Park, Seung Jung; Kim, Soo Joong; Ahn, Tae Hoon; Jang, Yangsoo; Ahn, Young Keun; Koh, Young Youp; Chung, Wook Sung.

In: Circulation Journal, Vol. 72, No. 9, 03.09.2008, p. 1410-1418.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical outcomes and therapeutic strategy in patients with acute myocardial infarction according to renal function - Data from the Korean Acute Myocardial Infarction Registry

AU - Lee, Sang Hee

AU - Kim, Young Jo

AU - Kim, Woong

AU - Park, Jong Seon

AU - Shin, Dong Gu

AU - Hur, Seung Ho

AU - Kim, Chong Jin

AU - Cho, Myeong Chan

AU - Chae, Shung Chull

AU - Jeong, Myung Ho

AU - Hong, Taek Jong

AU - Kim, Doo Il

AU - Kim, Kee Sik

AU - Koo, Bon Kwon

AU - Kim, Byung Ok

AU - Rhim, Chong Yun

AU - Choi, Donghoon

AU - Jin, Dong Kyu

AU - Gwon, Hyeon Cheol

AU - Chae, In Ho

AU - Seong, In Whan

AU - Rhew, Jae Young

AU - Bae, Jang Ho

AU - Chae, Jei Keon

AU - Cho, Jeong Gwan

AU - Cho, Jin Man

AU - Hwang, Jin Yong

AU - Kim, Jong Hyun

AU - Yoon, Junghan

AU - Yang, Ju Young

AU - Park, Keum Soo

AU - Seung, Ki Bae

AU - Han, Kyoo Rok

AU - Jeong, Kyoung Tae

AU - Kim, Moo Hyun

AU - Lee, Myoung Yong

AU - Lee, Nae Hee

AU - Oh, Seok Kyu

AU - Park, Seong Wook

AU - Rha, Seong Woon

AU - Joo, Seung Jae

AU - Tahk, Seung Jea

AU - Park, Seung Jung

AU - Kim, Soo Joong

AU - Ahn, Tae Hoon

AU - Jang, Yangsoo

AU - Ahn, Young Keun

AU - Koh, Young Youp

AU - Chung, Wook Sung

PY - 2008/9/3

Y1 - 2008/9/3

N2 - Background: The aim of the present study was to evaluate the relationship between clinical outcomes after acute myocardial infarction (MI) and renal function by glomerular filtration rate (GFR) in patients with normal or mildly elevated serum creatinine concentrations. Methods and Results: As part of the Korean Acute Myocardial Infarction Registry (KAMIR), 6,834 acute MI patients with a serum creatinine concentration of ≤2.0 mg/dl were enrolled from November 2005 to December 2006. The renal function was stratified arbitrary to 5 groups: (1) normal function, >90.0; (2) preserved function, 75.0-89.9; (3) mild dysfunction, 60.0-74.9; (4) moderate dysfunction, 45.0-59.9; (5) severe dysfunction, <45ml·min-1·;1.73m-2. Clinical characteristics, mortality and adverse events were analyzed among each group. Although reperfusion and medical therapies were underused, the rates of mortality and adverse events were increased with declining renal function. After adjustment with confounders, severe and moderate renal dysfunctions were important risk predictors of in-hospital mortality, long-term mortality and adverse events. Conclusion: The spectrum of renal function, when it was presented by GFR, is broad and is an important risk predictor for adverse outcomes after acute MI, even in patients with normal or mildly elevated serum creatinine concentrations. Furthermore, standard treatments were underused in any degree of renal dysfunction.

AB - Background: The aim of the present study was to evaluate the relationship between clinical outcomes after acute myocardial infarction (MI) and renal function by glomerular filtration rate (GFR) in patients with normal or mildly elevated serum creatinine concentrations. Methods and Results: As part of the Korean Acute Myocardial Infarction Registry (KAMIR), 6,834 acute MI patients with a serum creatinine concentration of ≤2.0 mg/dl were enrolled from November 2005 to December 2006. The renal function was stratified arbitrary to 5 groups: (1) normal function, >90.0; (2) preserved function, 75.0-89.9; (3) mild dysfunction, 60.0-74.9; (4) moderate dysfunction, 45.0-59.9; (5) severe dysfunction, <45ml·min-1·;1.73m-2. Clinical characteristics, mortality and adverse events were analyzed among each group. Although reperfusion and medical therapies were underused, the rates of mortality and adverse events were increased with declining renal function. After adjustment with confounders, severe and moderate renal dysfunctions were important risk predictors of in-hospital mortality, long-term mortality and adverse events. Conclusion: The spectrum of renal function, when it was presented by GFR, is broad and is an important risk predictor for adverse outcomes after acute MI, even in patients with normal or mildly elevated serum creatinine concentrations. Furthermore, standard treatments were underused in any degree of renal dysfunction.

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U2 - 10.1253/circj.CJ-08-0088

DO - 10.1253/circj.CJ-08-0088

M3 - Article

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SP - 1410

EP - 1418

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 9

ER -