Clinical outcomes following sirolimus-eluting stent implantation in patients with end-stage renal disease: Korean Multicenter Angioplasty Team (KOMATE) Registry

Byoung Keuk Kim, Sungjin Oh, Dong Woon Jeon, Donghoon Choi, Yangsoo Jang, Hyuck Moon Kwon, Jae Hun Jung, Kihwan Kwon, Joo Young Yang

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5 Citations (Scopus)

Abstract

Background and Objectives: Sirolimus-eluting stents (SES), as opposed to bare metal stents (BMS), have been shown to markedly reduce restenosis. However, many clinical trials have excluded the subset of patients (pts) with end-stage renal disease (ESRD). The aim of this study was to evaluate the clinical outcomes following SES implantation in ESRD pts. Subjects and Methods: We analyzed the clinical outcomes in 50 pts from our registry following SES implantation, and compared the outcomes between those with ESRD receiving SES (SES-ESRD) and BMS (BMS-ESRD), and with non-ESRD pts following SES implantation (SES-non ESRD). Results: A comparison of the SES-ESRD (50 pts, 72 lesions) with BMS-ESRD groups (42 pts, 45 lesions); those in the SES-ESRD group included; diabetes 78%, hypertension 94% and age 62 ±10 years. Those in the SES-ESRD group were more likely to have diabetes (diabetes of BMS-ESRD, 57%; p=0.04). The reference vessel diameters (RVD) of the SES-ESRD group were smaller (2.76±0.50 mm vs. 3.05±0.46 mm, p<0.001), but the lesion length was longer (25.6 ±7.0 mm vs. 19.1 ±8.8 mm, p<0.001) than those of the BMS-ESRD group. The SES-ESRD group had a lower 1-year major adverse cardiac events (MACE) rate than the BMS-ESRD group (6.0% vs. 33.3%; p< 0.001). There were no differences in mortality and incidence of myocardial infarction between the two groups. The incidence of target vessel revascularization decreased significantly in the SES-ESRD group (2.0% vs. 19.0%, p=0.01). From a multivariate regression analysis, the use of SES was the only significant independent predictor of MACE (OR=0.054, 95% confidence interval 0.01 to 0.26, p<0.001). A comparison with SES-non ESRD group in our total registry (644 pts, 758 lesions); MACE in the SES-ESRD group (6.0%) was higher than in the SES-non ESRD group (3.1%), but there was no statistical significance (p=0.23). Conclusion: Compared with BMS, SES caused an improvement in the clinical outcomes in pts with ESRD.

Original languageEnglish
Pages (from-to)424-430
Number of pages7
JournalKorean Circulation Journal
Volume36
Issue number6
DOIs
Publication statusPublished - 2006 Jun

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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