Clinical outcomes of endoscopic submucosal dissection for superficial esophageal squamous neoplasms

Jung Soo Park, Young Hoon Youn, Jae Jun Park, Jie-Hyun Kim, HyoJin Park

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background/Aims: Endoscopic treatment has been broadly applied to superficial esophageal neoplasms. Endoscopic submucosal dissection (ESD) allows for high rates of en bloc resection, precise histological assessment, and low rates of local recurrence. The aim of this study was to evaluate the outcomes of ESD for superficial esophageal neoplasms. Methods: We retrospectively reviewed 36 esophageal ESDs for superficial squamous neoplasms in 32 patients between March 2009 and August 2014 at Gangnam Severance Hospital. Results: The median patient age was 64 years, and 30 men were included. The indications were early squamous cell carcinoma in 26 lesions, adenoma with high-grade dysplasia in five lesions, and low-grade dysplasia in five lesions. The en bloc resection and R0 resection rates were 97.2% (35 of 36) and 91.7% (33 of 36), respectively. Microperforation and post-ESD bleeding occurred in 5.6% (2 of 36) and 5.6% (2 of 36), respectively. Post-ESD esophageal strictures developed in five patients (13.9%). Five patients (15.6%) had an additional treatment after ESD (concurrent chemoradiation therapy in three, radiation therapy in one, and surgery in one patient). There was no disease-specific mortality during the median follow-up of 31 months. Conclusions: Favorable clinical outcomes were observed in ESD for superficial esophageal squamous neoplasms. Esophageal ESD could be a good treatment option in terms of efficacy and safety.

Original languageEnglish
Pages (from-to)168-175
Number of pages8
JournalClinical Endoscopy
Volume49
Issue number2
DOIs
Publication statusPublished - 2016 Mar 16

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Esophageal Neoplasms
Esophageal Stenosis
Therapeutics
Endoscopic Mucosal Resection
Adenoma
Squamous Cell Carcinoma
Radiotherapy
Hemorrhage
Safety
Recurrence
Mortality
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

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title = "Clinical outcomes of endoscopic submucosal dissection for superficial esophageal squamous neoplasms",
abstract = "Background/Aims: Endoscopic treatment has been broadly applied to superficial esophageal neoplasms. Endoscopic submucosal dissection (ESD) allows for high rates of en bloc resection, precise histological assessment, and low rates of local recurrence. The aim of this study was to evaluate the outcomes of ESD for superficial esophageal neoplasms. Methods: We retrospectively reviewed 36 esophageal ESDs for superficial squamous neoplasms in 32 patients between March 2009 and August 2014 at Gangnam Severance Hospital. Results: The median patient age was 64 years, and 30 men were included. The indications were early squamous cell carcinoma in 26 lesions, adenoma with high-grade dysplasia in five lesions, and low-grade dysplasia in five lesions. The en bloc resection and R0 resection rates were 97.2{\%} (35 of 36) and 91.7{\%} (33 of 36), respectively. Microperforation and post-ESD bleeding occurred in 5.6{\%} (2 of 36) and 5.6{\%} (2 of 36), respectively. Post-ESD esophageal strictures developed in five patients (13.9{\%}). Five patients (15.6{\%}) had an additional treatment after ESD (concurrent chemoradiation therapy in three, radiation therapy in one, and surgery in one patient). There was no disease-specific mortality during the median follow-up of 31 months. Conclusions: Favorable clinical outcomes were observed in ESD for superficial esophageal squamous neoplasms. Esophageal ESD could be a good treatment option in terms of efficacy and safety.",
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Clinical outcomes of endoscopic submucosal dissection for superficial esophageal squamous neoplasms. / Park, Jung Soo; Youn, Young Hoon; Park, Jae Jun; Kim, Jie-Hyun; Park, HyoJin.

In: Clinical Endoscopy, Vol. 49, No. 2, 16.03.2016, p. 168-175.

Research output: Contribution to journalArticle

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