Clinical outcomes of transepithelial photorefractive keratectomy according to epithelial thickness

Ikhyun Jun, David Sung Yong Kang, Samuel Arba-Mosquera, Eung Kweon Kim, Kyoung Yul Seo, Tae Im Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PURPOSE: To investigate the clinical outcomes, vector parameters, and corneal aberrations of corneal wavefront-guided (CWFG) transepithelial photorefractive keratectomy (PRK), according to epithelial thickness. METHODS: This retrospective, comparative case series study included 91 eyes (91 patients) that underwent CWFG transepithelial PRK for myopic astigmatism. Epithelial thickness was less than 50 µm in 48 patients and 60 µm or greater in 43 patients. Clinical outcomes, including visual acuity, manifest refraction, vector parameters, and corneal wavefront aberration, were compared between the two groups. RESULTS: The mean uncorrected distance visual acuity, safety and efficacy indices, and aberrometric values were comparable between the two groups at 6 months after transepithelial PRK. The postoperative spherical equivalent was significantly different between the two groups: 0.05 ± 0.19 diopters (D) in the less than 50 µm group and -0.05 ± 0.18 D in the 60 µm or greater group (P = .009). The difference between the two groups was 0.10 D, which is less than the theoretical difference because the epithelial remodeling pattern was different. There was a slight difference in slope between target induced astigmatism vector and surgically induced astigmatism vector (0.9979 in the less than 50 µm group and 0.9145 in the 60 µm or greater group; P = .025). CONCLUSIONS: Transepithelial PRK is an effective and safe treatment modality regardless of epithelial thickness. However, a difference in postoperative refraction is present between the two groups, and astigmatic correction may be less in patients with thick epithelium; hence, a new algorithm is needed that can be tailored in accordance with individual epithelial thickness.

Original languageEnglish
Pages (from-to)533-540
Number of pages8
JournalJournal of Refractive Surgery
Volume34
Issue number8
DOIs
Publication statusPublished - 2018 Aug

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Photorefractive Keratectomy
Corneal Wavefront Aberration
Astigmatism
Visual Acuity
Epithelium
Safety

All Science Journal Classification (ASJC) codes

  • Surgery
  • Ophthalmology

Cite this

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title = "Clinical outcomes of transepithelial photorefractive keratectomy according to epithelial thickness",
abstract = "PURPOSE: To investigate the clinical outcomes, vector parameters, and corneal aberrations of corneal wavefront-guided (CWFG) transepithelial photorefractive keratectomy (PRK), according to epithelial thickness. METHODS: This retrospective, comparative case series study included 91 eyes (91 patients) that underwent CWFG transepithelial PRK for myopic astigmatism. Epithelial thickness was less than 50 µm in 48 patients and 60 µm or greater in 43 patients. Clinical outcomes, including visual acuity, manifest refraction, vector parameters, and corneal wavefront aberration, were compared between the two groups. RESULTS: The mean uncorrected distance visual acuity, safety and efficacy indices, and aberrometric values were comparable between the two groups at 6 months after transepithelial PRK. The postoperative spherical equivalent was significantly different between the two groups: 0.05 ± 0.19 diopters (D) in the less than 50 µm group and -0.05 ± 0.18 D in the 60 µm or greater group (P = .009). The difference between the two groups was 0.10 D, which is less than the theoretical difference because the epithelial remodeling pattern was different. There was a slight difference in slope between target induced astigmatism vector and surgically induced astigmatism vector (0.9979 in the less than 50 µm group and 0.9145 in the 60 µm or greater group; P = .025). CONCLUSIONS: Transepithelial PRK is an effective and safe treatment modality regardless of epithelial thickness. However, a difference in postoperative refraction is present between the two groups, and astigmatic correction may be less in patients with thick epithelium; hence, a new algorithm is needed that can be tailored in accordance with individual epithelial thickness.",
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Clinical outcomes of transepithelial photorefractive keratectomy according to epithelial thickness. / Jun, Ikhyun; Yong Kang, David Sung; Arba-Mosquera, Samuel; Kim, Eung Kweon; Seo, Kyoung Yul; Kim, Tae Im.

In: Journal of Refractive Surgery, Vol. 34, No. 8, 08.2018, p. 533-540.

Research output: Contribution to journalArticle

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T1 - Clinical outcomes of transepithelial photorefractive keratectomy according to epithelial thickness

AU - Jun, Ikhyun

AU - Yong Kang, David Sung

AU - Arba-Mosquera, Samuel

AU - Kim, Eung Kweon

AU - Seo, Kyoung Yul

AU - Kim, Tae Im

PY - 2018/8

Y1 - 2018/8

N2 - PURPOSE: To investigate the clinical outcomes, vector parameters, and corneal aberrations of corneal wavefront-guided (CWFG) transepithelial photorefractive keratectomy (PRK), according to epithelial thickness. METHODS: This retrospective, comparative case series study included 91 eyes (91 patients) that underwent CWFG transepithelial PRK for myopic astigmatism. Epithelial thickness was less than 50 µm in 48 patients and 60 µm or greater in 43 patients. Clinical outcomes, including visual acuity, manifest refraction, vector parameters, and corneal wavefront aberration, were compared between the two groups. RESULTS: The mean uncorrected distance visual acuity, safety and efficacy indices, and aberrometric values were comparable between the two groups at 6 months after transepithelial PRK. The postoperative spherical equivalent was significantly different between the two groups: 0.05 ± 0.19 diopters (D) in the less than 50 µm group and -0.05 ± 0.18 D in the 60 µm or greater group (P = .009). The difference between the two groups was 0.10 D, which is less than the theoretical difference because the epithelial remodeling pattern was different. There was a slight difference in slope between target induced astigmatism vector and surgically induced astigmatism vector (0.9979 in the less than 50 µm group and 0.9145 in the 60 µm or greater group; P = .025). CONCLUSIONS: Transepithelial PRK is an effective and safe treatment modality regardless of epithelial thickness. However, a difference in postoperative refraction is present between the two groups, and astigmatic correction may be less in patients with thick epithelium; hence, a new algorithm is needed that can be tailored in accordance with individual epithelial thickness.

AB - PURPOSE: To investigate the clinical outcomes, vector parameters, and corneal aberrations of corneal wavefront-guided (CWFG) transepithelial photorefractive keratectomy (PRK), according to epithelial thickness. METHODS: This retrospective, comparative case series study included 91 eyes (91 patients) that underwent CWFG transepithelial PRK for myopic astigmatism. Epithelial thickness was less than 50 µm in 48 patients and 60 µm or greater in 43 patients. Clinical outcomes, including visual acuity, manifest refraction, vector parameters, and corneal wavefront aberration, were compared between the two groups. RESULTS: The mean uncorrected distance visual acuity, safety and efficacy indices, and aberrometric values were comparable between the two groups at 6 months after transepithelial PRK. The postoperative spherical equivalent was significantly different between the two groups: 0.05 ± 0.19 diopters (D) in the less than 50 µm group and -0.05 ± 0.18 D in the 60 µm or greater group (P = .009). The difference between the two groups was 0.10 D, which is less than the theoretical difference because the epithelial remodeling pattern was different. There was a slight difference in slope between target induced astigmatism vector and surgically induced astigmatism vector (0.9979 in the less than 50 µm group and 0.9145 in the 60 µm or greater group; P = .025). CONCLUSIONS: Transepithelial PRK is an effective and safe treatment modality regardless of epithelial thickness. However, a difference in postoperative refraction is present between the two groups, and astigmatic correction may be less in patients with thick epithelium; hence, a new algorithm is needed that can be tailored in accordance with individual epithelial thickness.

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