Clinical practice guidelines for pre-analytical procedures of plasma epidermal growth factor receptor variant testing

Saeam Shin, Hye In Woo, Jong Won Kim, Yoonjung Kim, Kyung A. Lee

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this review, we provide evidence-based clinical practice guidelines for pre-analytical phase procedures of plasma epidermal growth factor receptor gene (EGFR) variant testing. Specific recommendations for pre-analytical procedures were proposed based on evidence from the literature and our experimental data. Standardization of pre-analytical procedures can improve the analytical performance of cfDNA testing.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalAnnals of laboratory medicine
Volume42
Issue number2
DOIs
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This study was supported by the Research Fund of Quality Control Committee, Korean Society for Laboratory Medicine (KSLM Research Project 2020-01-006) and Korean Society for Genetic Diagnostics.

Publisher Copyright:
© Korean Society for Laboratory Medicine.

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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