Clinical practice patterns of radiotherapy in patients with hepatocellular carcinoma: A Korean radiation oncology group study (KROG 14-07)

Hyejung Cha, Hee Chul Park, Jeong Il Yu, Tae Hyun Kim, Taek Keun Nam, Sang Min Yoon, Won Sup Yoon, Jun Won Kim, Mi Sook Kim, Hong Seok Jang, Youngmin Choi, Jin Hee Kim, Chul Seung Kay, Inkyung Jung, Jinsil Seong

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Abstract

Purpose The aim of this study was to examine patterns of radiotherapy (RT) in Korean patients with hepatocellular carcinoma (HCC) according to the evolving guideline for HCC established by the Korean Liver Cancer Study Group-National Cancer Center (KLCSG-NCC). Materials and Methods We reviewed 765 patients with HCC who were treated with RT between January 2011 and December 2012 in 12 institutions. Results The median follow-up period was 13.3 months (range 0.2 to 51.7 months). Compared with previous data between 2004 and 2005, the use of RT as a first treatment has increased (9.0% vs. 40.8%). Increased application of intensity-modulated RT resulted in an increase in radiation dose (fractional dose 1.8 Gy vs. 2.5 Gy; biologically effective dose 53.1 Gy10 vs. 56.3 Gy10). Median overall survival was 16.2 months, which is longer than that reported in previous data (12 months). In subgroup analysis, treatments were significantly different according to stage (p < 0.001). Stereotactic body RT was used in patients with early HCC, and most patients with advanced stage were treated with three-dimensional conformal RT. Conclusion Based on the evolving KLCSG-NCC practice guideline for HCC, clinical practice patterns of RT have changed. Although RT is still used mainly in advanced HCC, the number of patients with good performance status who were treated with RT as a first treatment has increased. This change in practice patterns could result in improvement in overall survival.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalCancer Research and Treatment
Volume49
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Physicians' Practice Patterns
Radiation Oncology
Hepatocellular Carcinoma
Radiotherapy
Liver Neoplasms
Conformal Radiotherapy
Intensity-Modulated Radiotherapy
Survival
Radiosurgery
Practice Guidelines
Neoplasms
Therapeutics
Guidelines
Radiation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Cha, Hyejung ; Park, Hee Chul ; Yu, Jeong Il ; Kim, Tae Hyun ; Nam, Taek Keun ; Yoon, Sang Min ; Yoon, Won Sup ; Kim, Jun Won ; Kim, Mi Sook ; Jang, Hong Seok ; Choi, Youngmin ; Kim, Jin Hee ; Kay, Chul Seung ; Jung, Inkyung ; Seong, Jinsil. / Clinical practice patterns of radiotherapy in patients with hepatocellular carcinoma : A Korean radiation oncology group study (KROG 14-07). In: Cancer Research and Treatment. 2017 ; Vol. 49, No. 1. pp. 61-69.
@article{64bbc7d3ce6b4b27956e4a00b2ac16fc,
title = "Clinical practice patterns of radiotherapy in patients with hepatocellular carcinoma: A Korean radiation oncology group study (KROG 14-07)",
abstract = "Purpose The aim of this study was to examine patterns of radiotherapy (RT) in Korean patients with hepatocellular carcinoma (HCC) according to the evolving guideline for HCC established by the Korean Liver Cancer Study Group-National Cancer Center (KLCSG-NCC). Materials and Methods We reviewed 765 patients with HCC who were treated with RT between January 2011 and December 2012 in 12 institutions. Results The median follow-up period was 13.3 months (range 0.2 to 51.7 months). Compared with previous data between 2004 and 2005, the use of RT as a first treatment has increased (9.0{\%} vs. 40.8{\%}). Increased application of intensity-modulated RT resulted in an increase in radiation dose (fractional dose 1.8 Gy vs. 2.5 Gy; biologically effective dose 53.1 Gy10 vs. 56.3 Gy10). Median overall survival was 16.2 months, which is longer than that reported in previous data (12 months). In subgroup analysis, treatments were significantly different according to stage (p < 0.001). Stereotactic body RT was used in patients with early HCC, and most patients with advanced stage were treated with three-dimensional conformal RT. Conclusion Based on the evolving KLCSG-NCC practice guideline for HCC, clinical practice patterns of RT have changed. Although RT is still used mainly in advanced HCC, the number of patients with good performance status who were treated with RT as a first treatment has increased. This change in practice patterns could result in improvement in overall survival.",
author = "Hyejung Cha and Park, {Hee Chul} and Yu, {Jeong Il} and Kim, {Tae Hyun} and Nam, {Taek Keun} and Yoon, {Sang Min} and Yoon, {Won Sup} and Kim, {Jun Won} and Kim, {Mi Sook} and Jang, {Hong Seok} and Youngmin Choi and Kim, {Jin Hee} and Kay, {Chul Seung} and Inkyung Jung and Jinsil Seong",
year = "2017",
month = "1",
day = "1",
doi = "10.4143/crt.2016.097",
language = "English",
volume = "49",
pages = "61--69",
journal = "Cancer Research and Treatment",
issn = "1598-2998",
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Cha, H, Park, HC, Yu, JI, Kim, TH, Nam, TK, Yoon, SM, Yoon, WS, Kim, JW, Kim, MS, Jang, HS, Choi, Y, Kim, JH, Kay, CS, Jung, I & Seong, J 2017, 'Clinical practice patterns of radiotherapy in patients with hepatocellular carcinoma: A Korean radiation oncology group study (KROG 14-07)', Cancer Research and Treatment, vol. 49, no. 1, pp. 61-69. https://doi.org/10.4143/crt.2016.097

Clinical practice patterns of radiotherapy in patients with hepatocellular carcinoma : A Korean radiation oncology group study (KROG 14-07). / Cha, Hyejung; Park, Hee Chul; Yu, Jeong Il; Kim, Tae Hyun; Nam, Taek Keun; Yoon, Sang Min; Yoon, Won Sup; Kim, Jun Won; Kim, Mi Sook; Jang, Hong Seok; Choi, Youngmin; Kim, Jin Hee; Kay, Chul Seung; Jung, Inkyung; Seong, Jinsil.

In: Cancer Research and Treatment, Vol. 49, No. 1, 01.01.2017, p. 61-69.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical practice patterns of radiotherapy in patients with hepatocellular carcinoma

T2 - A Korean radiation oncology group study (KROG 14-07)

AU - Cha, Hyejung

AU - Park, Hee Chul

AU - Yu, Jeong Il

AU - Kim, Tae Hyun

AU - Nam, Taek Keun

AU - Yoon, Sang Min

AU - Yoon, Won Sup

AU - Kim, Jun Won

AU - Kim, Mi Sook

AU - Jang, Hong Seok

AU - Choi, Youngmin

AU - Kim, Jin Hee

AU - Kay, Chul Seung

AU - Jung, Inkyung

AU - Seong, Jinsil

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Purpose The aim of this study was to examine patterns of radiotherapy (RT) in Korean patients with hepatocellular carcinoma (HCC) according to the evolving guideline for HCC established by the Korean Liver Cancer Study Group-National Cancer Center (KLCSG-NCC). Materials and Methods We reviewed 765 patients with HCC who were treated with RT between January 2011 and December 2012 in 12 institutions. Results The median follow-up period was 13.3 months (range 0.2 to 51.7 months). Compared with previous data between 2004 and 2005, the use of RT as a first treatment has increased (9.0% vs. 40.8%). Increased application of intensity-modulated RT resulted in an increase in radiation dose (fractional dose 1.8 Gy vs. 2.5 Gy; biologically effective dose 53.1 Gy10 vs. 56.3 Gy10). Median overall survival was 16.2 months, which is longer than that reported in previous data (12 months). In subgroup analysis, treatments were significantly different according to stage (p < 0.001). Stereotactic body RT was used in patients with early HCC, and most patients with advanced stage were treated with three-dimensional conformal RT. Conclusion Based on the evolving KLCSG-NCC practice guideline for HCC, clinical practice patterns of RT have changed. Although RT is still used mainly in advanced HCC, the number of patients with good performance status who were treated with RT as a first treatment has increased. This change in practice patterns could result in improvement in overall survival.

AB - Purpose The aim of this study was to examine patterns of radiotherapy (RT) in Korean patients with hepatocellular carcinoma (HCC) according to the evolving guideline for HCC established by the Korean Liver Cancer Study Group-National Cancer Center (KLCSG-NCC). Materials and Methods We reviewed 765 patients with HCC who were treated with RT between January 2011 and December 2012 in 12 institutions. Results The median follow-up period was 13.3 months (range 0.2 to 51.7 months). Compared with previous data between 2004 and 2005, the use of RT as a first treatment has increased (9.0% vs. 40.8%). Increased application of intensity-modulated RT resulted in an increase in radiation dose (fractional dose 1.8 Gy vs. 2.5 Gy; biologically effective dose 53.1 Gy10 vs. 56.3 Gy10). Median overall survival was 16.2 months, which is longer than that reported in previous data (12 months). In subgroup analysis, treatments were significantly different according to stage (p < 0.001). Stereotactic body RT was used in patients with early HCC, and most patients with advanced stage were treated with three-dimensional conformal RT. Conclusion Based on the evolving KLCSG-NCC practice guideline for HCC, clinical practice patterns of RT have changed. Although RT is still used mainly in advanced HCC, the number of patients with good performance status who were treated with RT as a first treatment has increased. This change in practice patterns could result in improvement in overall survival.

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