Clinical risk assessment for gastric cancer in asymptomatic population after a health check-up An individualized consideration of the risk factors

Yoo Mi Park, Jie Hyun Kim, Su Jung Baik, Jae Jun Park, Young Hoon Youn, Hyojin Park

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia. The clinicalandendoscopic findingsof60,261adultswhounderwentgastroduodenoscopyaspartof ahealthcheck-upwerereviewed retrospectively. Subgroup analysis was conducted according to age, sex, cancer stage, and histology based on Lauren classification. Gastric cancer was diagnosed in 75 patients (0.12%). Both IM and AG were independent risk factors for gastric cancer in all subgroups. Male, older age, obesity, diabetes mellitus (DM), a salty and spicy diet, and Helicobacter pylori (H. pylori) were significantly associated with precancerous conditions. However, risk factors related to precancerous conditions were different according to age and sex. In <40 years, H. pylori was the only risk factor related to precancerous conditions, whereas DM with a salty and spicy diet were additional risk factors in 40 years. In female individuals, obesity was significant risk factor for precancerous conditions as well as H. pylori infection. AG and IM are independent risk factors for gastric cancer. To prevent gastric cancer, H. pylori eradication may be more useful in <40 years, whereas additional factors such as DM, obesity, salty and spicy diet may be important in female or 40 years.

Original languageEnglish
Article numbere5351
JournalMedicine (United States)
Volume95
Issue number44
DOIs
Publication statusPublished - 2016 Jan 1

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Precancerous Conditions
Stomach Neoplasms
Health
Atrophic Gastritis
Helicobacter pylori
Population
Metaplasia
Diabetes Mellitus
Obesity
Diet
Helicobacter Infections
Histology

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia. The clinicalandendoscopic findingsof60,261adultswhounderwentgastroduodenoscopyaspartof ahealthcheck-upwerereviewed retrospectively. Subgroup analysis was conducted according to age, sex, cancer stage, and histology based on Lauren classification. Gastric cancer was diagnosed in 75 patients (0.12{\%}). Both IM and AG were independent risk factors for gastric cancer in all subgroups. Male, older age, obesity, diabetes mellitus (DM), a salty and spicy diet, and Helicobacter pylori (H. pylori) were significantly associated with precancerous conditions. However, risk factors related to precancerous conditions were different according to age and sex. In <40 years, H. pylori was the only risk factor related to precancerous conditions, whereas DM with a salty and spicy diet were additional risk factors in 40 years. In female individuals, obesity was significant risk factor for precancerous conditions as well as H. pylori infection. AG and IM are independent risk factors for gastric cancer. To prevent gastric cancer, H. pylori eradication may be more useful in <40 years, whereas additional factors such as DM, obesity, salty and spicy diet may be important in female or 40 years.",
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Clinical risk assessment for gastric cancer in asymptomatic population after a health check-up An individualized consideration of the risk factors. / Park, Yoo Mi; Kim, Jie Hyun; Baik, Su Jung; Park, Jae Jun; Youn, Young Hoon; Park, Hyojin.

In: Medicine (United States), Vol. 95, No. 44, e5351, 01.01.2016.

Research output: Contribution to journalArticle

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