Clinical safety of drug-eluting stents in the Korea acute myocardial infarction registry

Rok Lee Sang, Ho Jeong Myung, Keun Ahn Young, Chull Chae Shung, Ho Hur Seung, Jo Kim Young, Whan Seong In, Keon Chae Jei, Jong Hong Taek, Young Rhew Jae, Chan Cho Myeong, Ho Bae Jang, Woon Rha Seung, Jin Kim Chong, Yangsoo Jang, Jung Park Seung, Hyun Kim Jong, Donghoon Choi, Il Kim Doo, Ho Chae InHan Yoon Jung, Kwon Koo Bon, Ok Kim Byung, Yong Lee Myoung, Sik Kim Kee, Yong Hwang Jin, Kyu Oh Seok, Hee Lee Nae, Tae Jeong Kyoung, Jea Tahk Seung, Soo Park Keum, Rok Han Kyoo, Hoon Ahn Tae, Hyun Kim Moo, Bae Seung Ki, Sung Chung Wook, Young Yang Ju, Yun Rhim Chong, Cheol Gwon Hyeon, Wook Park Seong, Youp Koh Young, Jae Joo Seung, Joong Kim Soo, Kyu Jin Dong, Man Cho Jin, Gwan Cho Jeong

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may be useful in patients with acute myocardial infarction (AMI), but safety issues still need to be solved. This study was undertaken to investigate the incidence of major adverse cardiac events (MACE) and stent thrombosis in DES-implanted AMI patients in real-life clinical practice. Methods and Results: On-line registry of AMI cases at the web site www.kamir.or.kr has been performed in 41 primary PCI centers in Korea and between November 2005 and September 2006, 1,541 surviving patients who had been implanted with either Cypher® or Taxus® stents were enrolled for analysis during a 6-month clinical follow-up. There were 2 groups: group I [834 patients, 61.9±11.9 years: sirolimus-eluting stent (Cypher®)], group H [707 patients, 62.9±12.0 years: paclitaxel-eluting stent (Taxus®)]. At both 1 and 6 months the incidence of MACE was not significantly different between the 2 groups. There were 17 cases of stent thrombosis, but the incidence of stent thrombosis was not significantly different between the2 groups (group I:II=9 (1.1%): 8 (1.1%), p=1.000). The stent type, length, number, lesion complexity and diabetes were not significant for the incidence of MACE or stent thrombosis after adjustment. Conclusion: MACE and stent thrombosis rates did not differ between 2 types of DES identified in Korea Acute Myocardial Infarction Registry (KAMIR). DES can be used in patients with AMI with a relatively low 6-month MACE rate.

Original languageEnglish
Pages (from-to)392-398
Number of pages7
JournalCirculation Journal
Volume72
Issue number3
DOIs
Publication statusPublished - 2008 May 5

Fingerprint

Drug-Eluting Stents
Korea
Stents
Registries
Myocardial Infarction
Safety
Thrombosis
Taxus
Incidence
Percutaneous Coronary Intervention
Sirolimus
Paclitaxel

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Sang, R. L., Myung, H. J., Young, K. A., Shung, C. C., Seung, H. H., Young, J. K., ... Jeong, G. C. (2008). Clinical safety of drug-eluting stents in the Korea acute myocardial infarction registry. Circulation Journal, 72(3), 392-398. https://doi.org/10.1253/circj.72.392
Sang, Rok Lee ; Myung, Ho Jeong ; Young, Keun Ahn ; Shung, Chull Chae ; Seung, Ho Hur ; Young, Jo Kim ; In, Whan Seong ; Jei, Keon Chae ; Taek, Jong Hong ; Jae, Young Rhew ; Myeong, Chan Cho ; Jang, Ho Bae ; Seung, Woon Rha ; Chong, Jin Kim ; Jang, Yangsoo ; Seung, Jung Park ; Jong, Hyun Kim ; Choi, Donghoon ; Doo, Il Kim ; In, Ho Chae ; Jung, Han Yoon ; Bon, Kwon Koo ; Byung, Ok Kim ; Myoung, Yong Lee ; Kee, Sik Kim ; Jin, Yong Hwang ; Seok, Kyu Oh ; Nae, Hee Lee ; Kyoung, Tae Jeong ; Seung, Jea Tahk ; Keum, Soo Park ; Kyoo, Rok Han ; Tae, Hoon Ahn ; Moo, Hyun Kim ; Ki, Bae Seung ; Wook, Sung Chung ; Ju, Young Yang ; Chong, Yun Rhim ; Hyeon, Cheol Gwon ; Seong, Wook Park ; Young, Youp Koh ; Seung, Jae Joo ; Soo, Joong Kim ; Dong, Kyu Jin ; Jin, Man Cho ; Jeong, Gwan Cho. / Clinical safety of drug-eluting stents in the Korea acute myocardial infarction registry. In: Circulation Journal. 2008 ; Vol. 72, No. 3. pp. 392-398.
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abstract = "Background: Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may be useful in patients with acute myocardial infarction (AMI), but safety issues still need to be solved. This study was undertaken to investigate the incidence of major adverse cardiac events (MACE) and stent thrombosis in DES-implanted AMI patients in real-life clinical practice. Methods and Results: On-line registry of AMI cases at the web site www.kamir.or.kr has been performed in 41 primary PCI centers in Korea and between November 2005 and September 2006, 1,541 surviving patients who had been implanted with either Cypher{\circledR} or Taxus{\circledR} stents were enrolled for analysis during a 6-month clinical follow-up. There were 2 groups: group I [834 patients, 61.9±11.9 years: sirolimus-eluting stent (Cypher{\circledR})], group H [707 patients, 62.9±12.0 years: paclitaxel-eluting stent (Taxus{\circledR})]. At both 1 and 6 months the incidence of MACE was not significantly different between the 2 groups. There were 17 cases of stent thrombosis, but the incidence of stent thrombosis was not significantly different between the2 groups (group I:II=9 (1.1{\%}): 8 (1.1{\%}), p=1.000). The stent type, length, number, lesion complexity and diabetes were not significant for the incidence of MACE or stent thrombosis after adjustment. Conclusion: MACE and stent thrombosis rates did not differ between 2 types of DES identified in Korea Acute Myocardial Infarction Registry (KAMIR). DES can be used in patients with AMI with a relatively low 6-month MACE rate.",
author = "Sang, {Rok Lee} and Myung, {Ho Jeong} and Young, {Keun Ahn} and Shung, {Chull Chae} and Seung, {Ho Hur} and Young, {Jo Kim} and In, {Whan Seong} and Jei, {Keon Chae} and Taek, {Jong Hong} and Jae, {Young Rhew} and Myeong, {Chan Cho} and Jang, {Ho Bae} and Seung, {Woon Rha} and Chong, {Jin Kim} and Yangsoo Jang and Seung, {Jung Park} and Jong, {Hyun Kim} and Donghoon Choi and Doo, {Il Kim} and In, {Ho Chae} and Jung, {Han Yoon} and Bon, {Kwon Koo} and Byung, {Ok Kim} and Myoung, {Yong Lee} and Kee, {Sik Kim} and Jin, {Yong Hwang} and Seok, {Kyu Oh} and Nae, {Hee Lee} and Kyoung, {Tae Jeong} and Seung, {Jea Tahk} and Keum, {Soo Park} and Kyoo, {Rok Han} and Tae, {Hoon Ahn} and Moo, {Hyun Kim} and Ki, {Bae Seung} and Wook, {Sung Chung} and Ju, {Young Yang} and Chong, {Yun Rhim} and Hyeon, {Cheol Gwon} and Seong, {Wook Park} and Young, {Youp Koh} and Seung, {Jae Joo} and Soo, {Joong Kim} and Dong, {Kyu Jin} and Jin, {Man Cho} and Jeong, {Gwan Cho}",
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Sang, RL, Myung, HJ, Young, KA, Shung, CC, Seung, HH, Young, JK, In, WS, Jei, KC, Taek, JH, Jae, YR, Myeong, CC, Jang, HB, Seung, WR, Chong, JK, Jang, Y, Seung, JP, Jong, HK, Choi, D, Doo, IK, In, HC, Jung, HY, Bon, KK, Byung, OK, Myoung, YL, Kee, SK, Jin, YH, Seok, KO, Nae, HL, Kyoung, TJ, Seung, JT, Keum, SP, Kyoo, RH, Tae, HA, Moo, HK, Ki, BS, Wook, SC, Ju, YY, Chong, YR, Hyeon, CG, Seong, WP, Young, YK, Seung, JJ, Soo, JK, Dong, KJ, Jin, MC & Jeong, GC 2008, 'Clinical safety of drug-eluting stents in the Korea acute myocardial infarction registry', Circulation Journal, vol. 72, no. 3, pp. 392-398. https://doi.org/10.1253/circj.72.392

Clinical safety of drug-eluting stents in the Korea acute myocardial infarction registry. / Sang, Rok Lee; Myung, Ho Jeong; Young, Keun Ahn; Shung, Chull Chae; Seung, Ho Hur; Young, Jo Kim; In, Whan Seong; Jei, Keon Chae; Taek, Jong Hong; Jae, Young Rhew; Myeong, Chan Cho; Jang, Ho Bae; Seung, Woon Rha; Chong, Jin Kim; Jang, Yangsoo; Seung, Jung Park; Jong, Hyun Kim; Choi, Donghoon; Doo, Il Kim; In, Ho Chae; Jung, Han Yoon; Bon, Kwon Koo; Byung, Ok Kim; Myoung, Yong Lee; Kee, Sik Kim; Jin, Yong Hwang; Seok, Kyu Oh; Nae, Hee Lee; Kyoung, Tae Jeong; Seung, Jea Tahk; Keum, Soo Park; Kyoo, Rok Han; Tae, Hoon Ahn; Moo, Hyun Kim; Ki, Bae Seung; Wook, Sung Chung; Ju, Young Yang; Chong, Yun Rhim; Hyeon, Cheol Gwon; Seong, Wook Park; Young, Youp Koh; Seung, Jae Joo; Soo, Joong Kim; Dong, Kyu Jin; Jin, Man Cho; Jeong, Gwan Cho.

In: Circulation Journal, Vol. 72, No. 3, 05.05.2008, p. 392-398.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical safety of drug-eluting stents in the Korea acute myocardial infarction registry

AU - Sang, Rok Lee

AU - Myung, Ho Jeong

AU - Young, Keun Ahn

AU - Shung, Chull Chae

AU - Seung, Ho Hur

AU - Young, Jo Kim

AU - In, Whan Seong

AU - Jei, Keon Chae

AU - Taek, Jong Hong

AU - Jae, Young Rhew

AU - Myeong, Chan Cho

AU - Jang, Ho Bae

AU - Seung, Woon Rha

AU - Chong, Jin Kim

AU - Jang, Yangsoo

AU - Seung, Jung Park

AU - Jong, Hyun Kim

AU - Choi, Donghoon

AU - Doo, Il Kim

AU - In, Ho Chae

AU - Jung, Han Yoon

AU - Bon, Kwon Koo

AU - Byung, Ok Kim

AU - Myoung, Yong Lee

AU - Kee, Sik Kim

AU - Jin, Yong Hwang

AU - Seok, Kyu Oh

AU - Nae, Hee Lee

AU - Kyoung, Tae Jeong

AU - Seung, Jea Tahk

AU - Keum, Soo Park

AU - Kyoo, Rok Han

AU - Tae, Hoon Ahn

AU - Moo, Hyun Kim

AU - Ki, Bae Seung

AU - Wook, Sung Chung

AU - Ju, Young Yang

AU - Chong, Yun Rhim

AU - Hyeon, Cheol Gwon

AU - Seong, Wook Park

AU - Young, Youp Koh

AU - Seung, Jae Joo

AU - Soo, Joong Kim

AU - Dong, Kyu Jin

AU - Jin, Man Cho

AU - Jeong, Gwan Cho

PY - 2008/5/5

Y1 - 2008/5/5

N2 - Background: Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may be useful in patients with acute myocardial infarction (AMI), but safety issues still need to be solved. This study was undertaken to investigate the incidence of major adverse cardiac events (MACE) and stent thrombosis in DES-implanted AMI patients in real-life clinical practice. Methods and Results: On-line registry of AMI cases at the web site www.kamir.or.kr has been performed in 41 primary PCI centers in Korea and between November 2005 and September 2006, 1,541 surviving patients who had been implanted with either Cypher® or Taxus® stents were enrolled for analysis during a 6-month clinical follow-up. There were 2 groups: group I [834 patients, 61.9±11.9 years: sirolimus-eluting stent (Cypher®)], group H [707 patients, 62.9±12.0 years: paclitaxel-eluting stent (Taxus®)]. At both 1 and 6 months the incidence of MACE was not significantly different between the 2 groups. There were 17 cases of stent thrombosis, but the incidence of stent thrombosis was not significantly different between the2 groups (group I:II=9 (1.1%): 8 (1.1%), p=1.000). The stent type, length, number, lesion complexity and diabetes were not significant for the incidence of MACE or stent thrombosis after adjustment. Conclusion: MACE and stent thrombosis rates did not differ between 2 types of DES identified in Korea Acute Myocardial Infarction Registry (KAMIR). DES can be used in patients with AMI with a relatively low 6-month MACE rate.

AB - Background: Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may be useful in patients with acute myocardial infarction (AMI), but safety issues still need to be solved. This study was undertaken to investigate the incidence of major adverse cardiac events (MACE) and stent thrombosis in DES-implanted AMI patients in real-life clinical practice. Methods and Results: On-line registry of AMI cases at the web site www.kamir.or.kr has been performed in 41 primary PCI centers in Korea and between November 2005 and September 2006, 1,541 surviving patients who had been implanted with either Cypher® or Taxus® stents were enrolled for analysis during a 6-month clinical follow-up. There were 2 groups: group I [834 patients, 61.9±11.9 years: sirolimus-eluting stent (Cypher®)], group H [707 patients, 62.9±12.0 years: paclitaxel-eluting stent (Taxus®)]. At both 1 and 6 months the incidence of MACE was not significantly different between the 2 groups. There were 17 cases of stent thrombosis, but the incidence of stent thrombosis was not significantly different between the2 groups (group I:II=9 (1.1%): 8 (1.1%), p=1.000). The stent type, length, number, lesion complexity and diabetes were not significant for the incidence of MACE or stent thrombosis after adjustment. Conclusion: MACE and stent thrombosis rates did not differ between 2 types of DES identified in Korea Acute Myocardial Infarction Registry (KAMIR). DES can be used in patients with AMI with a relatively low 6-month MACE rate.

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