Clinical significance of a large difference (≥ 2 points) between biopsy and post-prostatectomy pathological gleason scores in patients with prostate cancer

Changhee Yoo, Cheol Young Oh, Jin Seon Cho, Cheryn Song, Seong Il Seo, Hanjong Ahn, Tae Kon Hwang, Jun Cheon, Kang Hyun Lee, Tae Gyun Kwon, Tae Young Jung, Moon Kee Chung, Sang Eun Lee, Hyun Moo Lee, Eun Sik Lee, Young Deuk Choi, Byung Ha Chung, Hyung Jin Kim, Wun Jae Kim, Seok Soo ByunHan Yong Choi

Research output: Contribution to journalArticle

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Abstract

We investigated the clinical significance of large difference (≥ 2 points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups: A (decreased in pGS ≥ 2, n = 30), B (changed in pGS ≤ 1, n = 1,361; control group), and C (increased in pGS ≥ 2, n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max%) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max% were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (P = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.

Original languageEnglish
Pages (from-to)507-512
Number of pages6
JournalJournal of Korean medical science
Volume26
Issue number4
DOIs
Publication statusPublished - 2011 Apr 1

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Neoplasm Grading
Prostatectomy
Prostatic Neoplasms
Biopsy
Korea
Tumor Burden
Multivariate Analysis
Control Groups
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yoo, Changhee ; Oh, Cheol Young ; Cho, Jin Seon ; Song, Cheryn ; Seo, Seong Il ; Ahn, Hanjong ; Hwang, Tae Kon ; Cheon, Jun ; Lee, Kang Hyun ; Kwon, Tae Gyun ; Jung, Tae Young ; Chung, Moon Kee ; Lee, Sang Eun ; Lee, Hyun Moo ; Lee, Eun Sik ; Choi, Young Deuk ; Chung, Byung Ha ; Kim, Hyung Jin ; Kim, Wun Jae ; Byun, Seok Soo ; Choi, Han Yong. / Clinical significance of a large difference (≥ 2 points) between biopsy and post-prostatectomy pathological gleason scores in patients with prostate cancer. In: Journal of Korean medical science. 2011 ; Vol. 26, No. 4. pp. 507-512.
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abstract = "We investigated the clinical significance of large difference (≥ 2 points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups: A (decreased in pGS ≥ 2, n = 30), B (changed in pGS ≤ 1, n = 1,361; control group), and C (increased in pGS ≥ 2, n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max{\%}) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max{\%} were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (P = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.",
author = "Changhee Yoo and Oh, {Cheol Young} and Cho, {Jin Seon} and Cheryn Song and Seo, {Seong Il} and Hanjong Ahn and Hwang, {Tae Kon} and Jun Cheon and Lee, {Kang Hyun} and Kwon, {Tae Gyun} and Jung, {Tae Young} and Chung, {Moon Kee} and Lee, {Sang Eun} and Lee, {Hyun Moo} and Lee, {Eun Sik} and Choi, {Young Deuk} and Chung, {Byung Ha} and Kim, {Hyung Jin} and Kim, {Wun Jae} and Byun, {Seok Soo} and Choi, {Han Yong}",
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Yoo, C, Oh, CY, Cho, JS, Song, C, Seo, SI, Ahn, H, Hwang, TK, Cheon, J, Lee, KH, Kwon, TG, Jung, TY, Chung, MK, Lee, SE, Lee, HM, Lee, ES, Choi, YD, Chung, BH, Kim, HJ, Kim, WJ, Byun, SS & Choi, HY 2011, 'Clinical significance of a large difference (≥ 2 points) between biopsy and post-prostatectomy pathological gleason scores in patients with prostate cancer', Journal of Korean medical science, vol. 26, no. 4, pp. 507-512. https://doi.org/10.3346/jkms.2011.26.4.507

Clinical significance of a large difference (≥ 2 points) between biopsy and post-prostatectomy pathological gleason scores in patients with prostate cancer. / Yoo, Changhee; Oh, Cheol Young; Cho, Jin Seon; Song, Cheryn; Seo, Seong Il; Ahn, Hanjong; Hwang, Tae Kon; Cheon, Jun; Lee, Kang Hyun; Kwon, Tae Gyun; Jung, Tae Young; Chung, Moon Kee; Lee, Sang Eun; Lee, Hyun Moo; Lee, Eun Sik; Choi, Young Deuk; Chung, Byung Ha; Kim, Hyung Jin; Kim, Wun Jae; Byun, Seok Soo; Choi, Han Yong.

In: Journal of Korean medical science, Vol. 26, No. 4, 01.04.2011, p. 507-512.

Research output: Contribution to journalArticle

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T1 - Clinical significance of a large difference (≥ 2 points) between biopsy and post-prostatectomy pathological gleason scores in patients with prostate cancer

AU - Yoo, Changhee

AU - Oh, Cheol Young

AU - Cho, Jin Seon

AU - Song, Cheryn

AU - Seo, Seong Il

AU - Ahn, Hanjong

AU - Hwang, Tae Kon

AU - Cheon, Jun

AU - Lee, Kang Hyun

AU - Kwon, Tae Gyun

AU - Jung, Tae Young

AU - Chung, Moon Kee

AU - Lee, Sang Eun

AU - Lee, Hyun Moo

AU - Lee, Eun Sik

AU - Choi, Young Deuk

AU - Chung, Byung Ha

AU - Kim, Hyung Jin

AU - Kim, Wun Jae

AU - Byun, Seok Soo

AU - Choi, Han Yong

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N2 - We investigated the clinical significance of large difference (≥ 2 points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups: A (decreased in pGS ≥ 2, n = 30), B (changed in pGS ≤ 1, n = 1,361; control group), and C (increased in pGS ≥ 2, n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max%) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max% were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (P = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.

AB - We investigated the clinical significance of large difference (≥ 2 points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups: A (decreased in pGS ≥ 2, n = 30), B (changed in pGS ≤ 1, n = 1,361; control group), and C (increased in pGS ≥ 2, n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max%) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max% were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (P = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.

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