Clinical significance of anti-annexin V antibody in acute cerebral ischemia

Kee Ook Lee, Won Joo Kim, Sang Jun Na, Ji Hoe Heo, Kyung Yul Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Antiphospholipid antibodies (aPLs) are associated with vascular occlusive events. Lupus anticoagulant (LA) and anticardiolipin antibody (aCL) are two aPLs commonly used for screening test. However, other aPLs are reported to play a role in the thrombotic events in other disorders, especially autoimmune disease. We investigated the clinical significance of the anti-annexin V antibody (aAV) in patients with acute cerebral ischemia; annexin V promotes anticoagulant activity via inhibition of prothrombin activation. Methods: A total of 187 patients with acute cerebral infarction or transient ischemic attack, and 66 control subjects were included in this prospective study. IgG type aAV was determined by enzyme-linked immunosorbent sandwich assay in the patient and control groups. The presence of LA and aCL were determined in the patient group using the usual screening method. Results: IgG aAV was detected in 26 of the 187 patients (13.9%), but only in three of the 66 control subjects (4.5%; P = 0.043). Among the 26 aAV positive patients, only five patients were positive for LA or aCL. The presence of IgG aAV was significantly associated with acute cerebral ischemia: one stroke event (OR, 4.39; 95% CI, 1.21-16.01), and two or more stroke events (OR, 3.91; 95% CI, 1.09-14.07). Conclusion: IgG aAV was detected in a significant percentage of the patients with acute cerebral ischemia compared with the control group. The presence of IgG aAV did not usually coincide with LA or aCL. Thus aAV should be considered as a possible associated factor for acute cerebral ischemia.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalJournal of the Neurological Sciences
Volume305
Issue number1-2
DOIs
Publication statusPublished - 2011 Jun 15

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Annexin A5
Brain Ischemia
Antibodies
Lupus Coagulation Inhibitor
Anticardiolipin Antibodies
Antiphospholipid Antibodies
Stroke
Control Groups
Transient Ischemic Attack
Cerebral Infarction
Prothrombin
Anticoagulants
Autoimmune Diseases
Blood Vessels
Enzyme-Linked Immunosorbent Assay
anti-IgG
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Lee, Kee Ook ; Kim, Won Joo ; Na, Sang Jun ; Heo, Ji Hoe ; Lee, Kyung Yul. / Clinical significance of anti-annexin V antibody in acute cerebral ischemia. In: Journal of the Neurological Sciences. 2011 ; Vol. 305, No. 1-2. pp. 53-56.
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abstract = "Background: Antiphospholipid antibodies (aPLs) are associated with vascular occlusive events. Lupus anticoagulant (LA) and anticardiolipin antibody (aCL) are two aPLs commonly used for screening test. However, other aPLs are reported to play a role in the thrombotic events in other disorders, especially autoimmune disease. We investigated the clinical significance of the anti-annexin V antibody (aAV) in patients with acute cerebral ischemia; annexin V promotes anticoagulant activity via inhibition of prothrombin activation. Methods: A total of 187 patients with acute cerebral infarction or transient ischemic attack, and 66 control subjects were included in this prospective study. IgG type aAV was determined by enzyme-linked immunosorbent sandwich assay in the patient and control groups. The presence of LA and aCL were determined in the patient group using the usual screening method. Results: IgG aAV was detected in 26 of the 187 patients (13.9{\%}), but only in three of the 66 control subjects (4.5{\%}; P = 0.043). Among the 26 aAV positive patients, only five patients were positive for LA or aCL. The presence of IgG aAV was significantly associated with acute cerebral ischemia: one stroke event (OR, 4.39; 95{\%} CI, 1.21-16.01), and two or more stroke events (OR, 3.91; 95{\%} CI, 1.09-14.07). Conclusion: IgG aAV was detected in a significant percentage of the patients with acute cerebral ischemia compared with the control group. The presence of IgG aAV did not usually coincide with LA or aCL. Thus aAV should be considered as a possible associated factor for acute cerebral ischemia.",
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Clinical significance of anti-annexin V antibody in acute cerebral ischemia. / Lee, Kee Ook; Kim, Won Joo; Na, Sang Jun; Heo, Ji Hoe; Lee, Kyung Yul.

In: Journal of the Neurological Sciences, Vol. 305, No. 1-2, 15.06.2011, p. 53-56.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical significance of anti-annexin V antibody in acute cerebral ischemia

AU - Lee, Kee Ook

AU - Kim, Won Joo

AU - Na, Sang Jun

AU - Heo, Ji Hoe

AU - Lee, Kyung Yul

PY - 2011/6/15

Y1 - 2011/6/15

N2 - Background: Antiphospholipid antibodies (aPLs) are associated with vascular occlusive events. Lupus anticoagulant (LA) and anticardiolipin antibody (aCL) are two aPLs commonly used for screening test. However, other aPLs are reported to play a role in the thrombotic events in other disorders, especially autoimmune disease. We investigated the clinical significance of the anti-annexin V antibody (aAV) in patients with acute cerebral ischemia; annexin V promotes anticoagulant activity via inhibition of prothrombin activation. Methods: A total of 187 patients with acute cerebral infarction or transient ischemic attack, and 66 control subjects were included in this prospective study. IgG type aAV was determined by enzyme-linked immunosorbent sandwich assay in the patient and control groups. The presence of LA and aCL were determined in the patient group using the usual screening method. Results: IgG aAV was detected in 26 of the 187 patients (13.9%), but only in three of the 66 control subjects (4.5%; P = 0.043). Among the 26 aAV positive patients, only five patients were positive for LA or aCL. The presence of IgG aAV was significantly associated with acute cerebral ischemia: one stroke event (OR, 4.39; 95% CI, 1.21-16.01), and two or more stroke events (OR, 3.91; 95% CI, 1.09-14.07). Conclusion: IgG aAV was detected in a significant percentage of the patients with acute cerebral ischemia compared with the control group. The presence of IgG aAV did not usually coincide with LA or aCL. Thus aAV should be considered as a possible associated factor for acute cerebral ischemia.

AB - Background: Antiphospholipid antibodies (aPLs) are associated with vascular occlusive events. Lupus anticoagulant (LA) and anticardiolipin antibody (aCL) are two aPLs commonly used for screening test. However, other aPLs are reported to play a role in the thrombotic events in other disorders, especially autoimmune disease. We investigated the clinical significance of the anti-annexin V antibody (aAV) in patients with acute cerebral ischemia; annexin V promotes anticoagulant activity via inhibition of prothrombin activation. Methods: A total of 187 patients with acute cerebral infarction or transient ischemic attack, and 66 control subjects were included in this prospective study. IgG type aAV was determined by enzyme-linked immunosorbent sandwich assay in the patient and control groups. The presence of LA and aCL were determined in the patient group using the usual screening method. Results: IgG aAV was detected in 26 of the 187 patients (13.9%), but only in three of the 66 control subjects (4.5%; P = 0.043). Among the 26 aAV positive patients, only five patients were positive for LA or aCL. The presence of IgG aAV was significantly associated with acute cerebral ischemia: one stroke event (OR, 4.39; 95% CI, 1.21-16.01), and two or more stroke events (OR, 3.91; 95% CI, 1.09-14.07). Conclusion: IgG aAV was detected in a significant percentage of the patients with acute cerebral ischemia compared with the control group. The presence of IgG aAV did not usually coincide with LA or aCL. Thus aAV should be considered as a possible associated factor for acute cerebral ischemia.

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