Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy

Jung Hee Lee, Jae Sun Uhm, Dong Geum Shin, Boyoung Joung, Hui Nam Pak, Young Guk Ko, Geu Ru Hong, Moon Hyoung Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: Although transient changes in the electrocardiogram (ECG) of patients with stress-induced cardiomyopathy (SCMP) are common, there are little data about ECG changes in patients with SCMP and the clinical implications of these variations. Methods: We investigated a total of 128 patients (age, 63.2 ± 15.4 years; female, 60.9%) diagnosed with SCMP. We compared the ECGs taken after SCMP diagnosis and during the recovery phase to those taken before SCMP diagnosis under baseline conditions. All patients were divided into two groups according to corrected QT (QTc) interval changes: recovered QTc group (QTc in SCMP > QTc in recovery phase, n = 77) and nonrecovered QTc group (QTc in SCMP ≤ QTc in recovery phase, n = 51). Results: In comparison of baseline, SCMP, and recovery phase, we found the mean heart rate (81.5 ± 18.7, 96.8 ± 25.3, and 83.0 ± 19.4/min, respectively; p < 0.001), frequencies of ST segment elevation (0.0%, 8.6%, and 1.6%, p = 0.004), ST segment depression (0.0%, 6.3%, and 1.6%, p = 0.007), T wave inversion (4.4%, 43.8%, and 61.7%, p < 0.001), and QTc (447.4 ± 35.3, 488.9 ± 67.1, and 468.0 ± 49.5, p < 0.001) showed significant changes. In-hospital mortality (9.1% vs. 25.5%, p = 0.012) and critical care (54.5% vs. 72.5%, p = 0.040) occurred more frequently in the nonrecovered QTc group than in recovered QTc group. Conclusions: The QTc can be prolonged in patients with SCMP. Short-term mortality was increased in patients where the QTc did not recover.

Original languageEnglish
Pages (from-to)507-516
Number of pages10
JournalKorean Journal of Internal Medicine
Volume31
Issue number3
DOIs
Publication statusPublished - 2016 May

Fingerprint

Takotsubo Cardiomyopathy
Electrocardiography
Critical Care
Hospital Mortality
Heart Rate

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Lee, Jung Hee ; Uhm, Jae Sun ; Shin, Dong Geum ; Joung, Boyoung ; Pak, Hui Nam ; Ko, Young Guk ; Hong, Geu Ru ; Lee, Moon Hyoung. / Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy. In: Korean Journal of Internal Medicine. 2016 ; Vol. 31, No. 3. pp. 507-516.
@article{759fd63b8ae54a738ccdd087b0d69eb2,
title = "Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy",
abstract = "Background/Aims: Although transient changes in the electrocardiogram (ECG) of patients with stress-induced cardiomyopathy (SCMP) are common, there are little data about ECG changes in patients with SCMP and the clinical implications of these variations. Methods: We investigated a total of 128 patients (age, 63.2 ± 15.4 years; female, 60.9{\%}) diagnosed with SCMP. We compared the ECGs taken after SCMP diagnosis and during the recovery phase to those taken before SCMP diagnosis under baseline conditions. All patients were divided into two groups according to corrected QT (QTc) interval changes: recovered QTc group (QTc in SCMP > QTc in recovery phase, n = 77) and nonrecovered QTc group (QTc in SCMP ≤ QTc in recovery phase, n = 51). Results: In comparison of baseline, SCMP, and recovery phase, we found the mean heart rate (81.5 ± 18.7, 96.8 ± 25.3, and 83.0 ± 19.4/min, respectively; p < 0.001), frequencies of ST segment elevation (0.0{\%}, 8.6{\%}, and 1.6{\%}, p = 0.004), ST segment depression (0.0{\%}, 6.3{\%}, and 1.6{\%}, p = 0.007), T wave inversion (4.4{\%}, 43.8{\%}, and 61.7{\%}, p < 0.001), and QTc (447.4 ± 35.3, 488.9 ± 67.1, and 468.0 ± 49.5, p < 0.001) showed significant changes. In-hospital mortality (9.1{\%} vs. 25.5{\%}, p = 0.012) and critical care (54.5{\%} vs. 72.5{\%}, p = 0.040) occurred more frequently in the nonrecovered QTc group than in recovered QTc group. Conclusions: The QTc can be prolonged in patients with SCMP. Short-term mortality was increased in patients where the QTc did not recover.",
author = "Lee, {Jung Hee} and Uhm, {Jae Sun} and Shin, {Dong Geum} and Boyoung Joung and Pak, {Hui Nam} and Ko, {Young Guk} and Hong, {Geu Ru} and Lee, {Moon Hyoung}",
year = "2016",
month = "5",
doi = "10.3904/kjim.2015.330",
language = "English",
volume = "31",
pages = "507--516",
journal = "Korean Journal of Internal Medicine",
issn = "1226-3303",
publisher = "Korean Association of Internal Medicine",
number = "3",

}

Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy. / Lee, Jung Hee; Uhm, Jae Sun; Shin, Dong Geum; Joung, Boyoung; Pak, Hui Nam; Ko, Young Guk; Hong, Geu Ru; Lee, Moon Hyoung.

In: Korean Journal of Internal Medicine, Vol. 31, No. 3, 05.2016, p. 507-516.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy

AU - Lee, Jung Hee

AU - Uhm, Jae Sun

AU - Shin, Dong Geum

AU - Joung, Boyoung

AU - Pak, Hui Nam

AU - Ko, Young Guk

AU - Hong, Geu Ru

AU - Lee, Moon Hyoung

PY - 2016/5

Y1 - 2016/5

N2 - Background/Aims: Although transient changes in the electrocardiogram (ECG) of patients with stress-induced cardiomyopathy (SCMP) are common, there are little data about ECG changes in patients with SCMP and the clinical implications of these variations. Methods: We investigated a total of 128 patients (age, 63.2 ± 15.4 years; female, 60.9%) diagnosed with SCMP. We compared the ECGs taken after SCMP diagnosis and during the recovery phase to those taken before SCMP diagnosis under baseline conditions. All patients were divided into two groups according to corrected QT (QTc) interval changes: recovered QTc group (QTc in SCMP > QTc in recovery phase, n = 77) and nonrecovered QTc group (QTc in SCMP ≤ QTc in recovery phase, n = 51). Results: In comparison of baseline, SCMP, and recovery phase, we found the mean heart rate (81.5 ± 18.7, 96.8 ± 25.3, and 83.0 ± 19.4/min, respectively; p < 0.001), frequencies of ST segment elevation (0.0%, 8.6%, and 1.6%, p = 0.004), ST segment depression (0.0%, 6.3%, and 1.6%, p = 0.007), T wave inversion (4.4%, 43.8%, and 61.7%, p < 0.001), and QTc (447.4 ± 35.3, 488.9 ± 67.1, and 468.0 ± 49.5, p < 0.001) showed significant changes. In-hospital mortality (9.1% vs. 25.5%, p = 0.012) and critical care (54.5% vs. 72.5%, p = 0.040) occurred more frequently in the nonrecovered QTc group than in recovered QTc group. Conclusions: The QTc can be prolonged in patients with SCMP. Short-term mortality was increased in patients where the QTc did not recover.

AB - Background/Aims: Although transient changes in the electrocardiogram (ECG) of patients with stress-induced cardiomyopathy (SCMP) are common, there are little data about ECG changes in patients with SCMP and the clinical implications of these variations. Methods: We investigated a total of 128 patients (age, 63.2 ± 15.4 years; female, 60.9%) diagnosed with SCMP. We compared the ECGs taken after SCMP diagnosis and during the recovery phase to those taken before SCMP diagnosis under baseline conditions. All patients were divided into two groups according to corrected QT (QTc) interval changes: recovered QTc group (QTc in SCMP > QTc in recovery phase, n = 77) and nonrecovered QTc group (QTc in SCMP ≤ QTc in recovery phase, n = 51). Results: In comparison of baseline, SCMP, and recovery phase, we found the mean heart rate (81.5 ± 18.7, 96.8 ± 25.3, and 83.0 ± 19.4/min, respectively; p < 0.001), frequencies of ST segment elevation (0.0%, 8.6%, and 1.6%, p = 0.004), ST segment depression (0.0%, 6.3%, and 1.6%, p = 0.007), T wave inversion (4.4%, 43.8%, and 61.7%, p < 0.001), and QTc (447.4 ± 35.3, 488.9 ± 67.1, and 468.0 ± 49.5, p < 0.001) showed significant changes. In-hospital mortality (9.1% vs. 25.5%, p = 0.012) and critical care (54.5% vs. 72.5%, p = 0.040) occurred more frequently in the nonrecovered QTc group than in recovered QTc group. Conclusions: The QTc can be prolonged in patients with SCMP. Short-term mortality was increased in patients where the QTc did not recover.

UR - http://www.scopus.com/inward/record.url?scp=84965062111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965062111&partnerID=8YFLogxK

U2 - 10.3904/kjim.2015.330

DO - 10.3904/kjim.2015.330

M3 - Article

C2 - 27052264

AN - SCOPUS:84965062111

VL - 31

SP - 507

EP - 516

JO - Korean Journal of Internal Medicine

JF - Korean Journal of Internal Medicine

SN - 1226-3303

IS - 3

ER -