Clinical significance of distal colon polyps for the prediction of an advanced proximal neoplasm

The KASID prospective multicenter study

Mun Su Kang, Dong Il Park, Yoon Tae Jeen, Bora Keum, Jai Hyun Choi, Sung Ae Jung, Hyunsoo Kim, Young Ho Kim, Won Ho Kim, Tae Il Kim, Hyo Jung Kim, Suk Kyun Yang, Seung Jae Myung, Jeong Sik Byeon, Moon Sung Lee, Il Kwon Jung, Moon Kwan Chung, Hwang Choi, Dong Soo Han, Jae Suk Song

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/aims: The possibility of proximal lesion without distal polyps is a weak point of sigmoidoscopic colon cancer screening, but the clinical significance of distal findings for advanced proximal neoplasm (APN) is uncertain. The aim of this study was to assess the significance of a distal finding as a predictor of APN. Materials and methods: Asymptomatic patients ≥50 years old were enrolled from among patients who underwent polypectomy at 11 tertiary medical centers during the Korean Association for the Study of Intestinal Disease prospective study conducted between July 2003 and March 2004. Polyps located distal to the splenic flexure were defined as distal polyps. An advanced neoplasm was defined as a polyp of ≥10 mm in size, and/or with villous features, and/or with high-grade dysplasia, or invasive cancer. Age, gender, and distal polyp size, appearance, and histology were analyzed as risk factors of APN. The sensitivity and positive predictive value of distal polyps for APN were calculated. Results: Data from 826 patients were analyzed. Mean patient age was 60.1 years (range 50-86), and 71.3% were men. APN was found in 98 patients, and 45 (45.9%) patients had no distal polyps. Risk factors of APN were a male gender, distal polyp size, and an advanced distal neoplasm. Sensitivities of a distal polyp of ≥10 mm and of an advanced distal neoplasm for APN were both 38.8% with positive predictive values of 13.3 and 14.4%, respectively. Conclusions: Although distal colon findings were found to be helpful for predicting APN in asymptomatic patients aged ≥50 years, APN without distal polyps requires careful consideration.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalInternational Journal of Colorectal Disease
Volume23
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

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Polyps
Multicenter Studies
Colon
Prospective Studies
Neoplasms
Intestinal Diseases
Transverse Colon
Early Detection of Cancer
Colonic Neoplasms
Histology

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kang, Mun Su ; Park, Dong Il ; Jeen, Yoon Tae ; Keum, Bora ; Choi, Jai Hyun ; Jung, Sung Ae ; Kim, Hyunsoo ; Kim, Young Ho ; Kim, Won Ho ; Kim, Tae Il ; Kim, Hyo Jung ; Yang, Suk Kyun ; Myung, Seung Jae ; Byeon, Jeong Sik ; Lee, Moon Sung ; Jung, Il Kwon ; Chung, Moon Kwan ; Choi, Hwang ; Han, Dong Soo ; Song, Jae Suk. / Clinical significance of distal colon polyps for the prediction of an advanced proximal neoplasm : The KASID prospective multicenter study. In: International Journal of Colorectal Disease. 2008 ; Vol. 23, No. 2. pp. 171-176.
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title = "Clinical significance of distal colon polyps for the prediction of an advanced proximal neoplasm: The KASID prospective multicenter study",
abstract = "Background/aims: The possibility of proximal lesion without distal polyps is a weak point of sigmoidoscopic colon cancer screening, but the clinical significance of distal findings for advanced proximal neoplasm (APN) is uncertain. The aim of this study was to assess the significance of a distal finding as a predictor of APN. Materials and methods: Asymptomatic patients ≥50 years old were enrolled from among patients who underwent polypectomy at 11 tertiary medical centers during the Korean Association for the Study of Intestinal Disease prospective study conducted between July 2003 and March 2004. Polyps located distal to the splenic flexure were defined as distal polyps. An advanced neoplasm was defined as a polyp of ≥10 mm in size, and/or with villous features, and/or with high-grade dysplasia, or invasive cancer. Age, gender, and distal polyp size, appearance, and histology were analyzed as risk factors of APN. The sensitivity and positive predictive value of distal polyps for APN were calculated. Results: Data from 826 patients were analyzed. Mean patient age was 60.1 years (range 50-86), and 71.3{\%} were men. APN was found in 98 patients, and 45 (45.9{\%}) patients had no distal polyps. Risk factors of APN were a male gender, distal polyp size, and an advanced distal neoplasm. Sensitivities of a distal polyp of ≥10 mm and of an advanced distal neoplasm for APN were both 38.8{\%} with positive predictive values of 13.3 and 14.4{\%}, respectively. Conclusions: Although distal colon findings were found to be helpful for predicting APN in asymptomatic patients aged ≥50 years, APN without distal polyps requires careful consideration.",
author = "Kang, {Mun Su} and Park, {Dong Il} and Jeen, {Yoon Tae} and Bora Keum and Choi, {Jai Hyun} and Jung, {Sung Ae} and Hyunsoo Kim and Kim, {Young Ho} and Kim, {Won Ho} and Kim, {Tae Il} and Kim, {Hyo Jung} and Yang, {Suk Kyun} and Myung, {Seung Jae} and Byeon, {Jeong Sik} and Lee, {Moon Sung} and Jung, {Il Kwon} and Chung, {Moon Kwan} and Hwang Choi and Han, {Dong Soo} and Song, {Jae Suk}",
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Kang, MS, Park, DI, Jeen, YT, Keum, B, Choi, JH, Jung, SA, Kim, H, Kim, YH, Kim, WH, Kim, TI, Kim, HJ, Yang, SK, Myung, SJ, Byeon, JS, Lee, MS, Jung, IK, Chung, MK, Choi, H, Han, DS & Song, JS 2008, 'Clinical significance of distal colon polyps for the prediction of an advanced proximal neoplasm: The KASID prospective multicenter study', International Journal of Colorectal Disease, vol. 23, no. 2, pp. 171-176. https://doi.org/10.1007/s00384-007-0387-7

Clinical significance of distal colon polyps for the prediction of an advanced proximal neoplasm : The KASID prospective multicenter study. / Kang, Mun Su; Park, Dong Il; Jeen, Yoon Tae; Keum, Bora; Choi, Jai Hyun; Jung, Sung Ae; Kim, Hyunsoo; Kim, Young Ho; Kim, Won Ho; Kim, Tae Il; Kim, Hyo Jung; Yang, Suk Kyun; Myung, Seung Jae; Byeon, Jeong Sik; Lee, Moon Sung; Jung, Il Kwon; Chung, Moon Kwan; Choi, Hwang; Han, Dong Soo; Song, Jae Suk.

In: International Journal of Colorectal Disease, Vol. 23, No. 2, 01.02.2008, p. 171-176.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical significance of distal colon polyps for the prediction of an advanced proximal neoplasm

T2 - The KASID prospective multicenter study

AU - Kang, Mun Su

AU - Park, Dong Il

AU - Jeen, Yoon Tae

AU - Keum, Bora

AU - Choi, Jai Hyun

AU - Jung, Sung Ae

AU - Kim, Hyunsoo

AU - Kim, Young Ho

AU - Kim, Won Ho

AU - Kim, Tae Il

AU - Kim, Hyo Jung

AU - Yang, Suk Kyun

AU - Myung, Seung Jae

AU - Byeon, Jeong Sik

AU - Lee, Moon Sung

AU - Jung, Il Kwon

AU - Chung, Moon Kwan

AU - Choi, Hwang

AU - Han, Dong Soo

AU - Song, Jae Suk

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Background/aims: The possibility of proximal lesion without distal polyps is a weak point of sigmoidoscopic colon cancer screening, but the clinical significance of distal findings for advanced proximal neoplasm (APN) is uncertain. The aim of this study was to assess the significance of a distal finding as a predictor of APN. Materials and methods: Asymptomatic patients ≥50 years old were enrolled from among patients who underwent polypectomy at 11 tertiary medical centers during the Korean Association for the Study of Intestinal Disease prospective study conducted between July 2003 and March 2004. Polyps located distal to the splenic flexure were defined as distal polyps. An advanced neoplasm was defined as a polyp of ≥10 mm in size, and/or with villous features, and/or with high-grade dysplasia, or invasive cancer. Age, gender, and distal polyp size, appearance, and histology were analyzed as risk factors of APN. The sensitivity and positive predictive value of distal polyps for APN were calculated. Results: Data from 826 patients were analyzed. Mean patient age was 60.1 years (range 50-86), and 71.3% were men. APN was found in 98 patients, and 45 (45.9%) patients had no distal polyps. Risk factors of APN were a male gender, distal polyp size, and an advanced distal neoplasm. Sensitivities of a distal polyp of ≥10 mm and of an advanced distal neoplasm for APN were both 38.8% with positive predictive values of 13.3 and 14.4%, respectively. Conclusions: Although distal colon findings were found to be helpful for predicting APN in asymptomatic patients aged ≥50 years, APN without distal polyps requires careful consideration.

AB - Background/aims: The possibility of proximal lesion without distal polyps is a weak point of sigmoidoscopic colon cancer screening, but the clinical significance of distal findings for advanced proximal neoplasm (APN) is uncertain. The aim of this study was to assess the significance of a distal finding as a predictor of APN. Materials and methods: Asymptomatic patients ≥50 years old were enrolled from among patients who underwent polypectomy at 11 tertiary medical centers during the Korean Association for the Study of Intestinal Disease prospective study conducted between July 2003 and March 2004. Polyps located distal to the splenic flexure were defined as distal polyps. An advanced neoplasm was defined as a polyp of ≥10 mm in size, and/or with villous features, and/or with high-grade dysplasia, or invasive cancer. Age, gender, and distal polyp size, appearance, and histology were analyzed as risk factors of APN. The sensitivity and positive predictive value of distal polyps for APN were calculated. Results: Data from 826 patients were analyzed. Mean patient age was 60.1 years (range 50-86), and 71.3% were men. APN was found in 98 patients, and 45 (45.9%) patients had no distal polyps. Risk factors of APN were a male gender, distal polyp size, and an advanced distal neoplasm. Sensitivities of a distal polyp of ≥10 mm and of an advanced distal neoplasm for APN were both 38.8% with positive predictive values of 13.3 and 14.4%, respectively. Conclusions: Although distal colon findings were found to be helpful for predicting APN in asymptomatic patients aged ≥50 years, APN without distal polyps requires careful consideration.

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U2 - 10.1007/s00384-007-0387-7

DO - 10.1007/s00384-007-0387-7

M3 - Article

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EP - 176

JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

SN - 0179-1958

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