Clinical significance of lymph node dissection in patients with muscle-invasive upper urinary tract transitional cell carcinoma treated with nephroureterectomy

Kang Su Cho, Hyun Min Choi, Kyochul Koo, Sung Jin Park, Koon Ho Rha, Young Deuk Choi, Byung Ha Chung, Nam Hoon Cho, Seung Choul Yang, Sung Joon Hong

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Abstract

We investigated the value of lymph node dissection in patients with cN0 muscle-invasive transitional cell carcinoma of the upper urinary tract (UUT-TCC). Medical records of 152 patients with cN0 muscle-invasive UUT-TCC, who underwent nephroureterectomy between 1986 and 2005, were reviewed. Sixty-three patients (41.4%) underwent lymph node dissection. The median number of lymph nodes harvested was 6 (range, 1 to 35), and from these, lymph node involvement was confirmed in 9 patients (14.3%). Locoregional recurrence (LR) and disease-recurrence (DR) occurred in 29 patients and 63 patients, respectively. Fifty-five patients (36.2%) had died of cancer at the last follow-up. The number of lymph nodes harvested was associated with the reduction of LR (x2 trend=6.755, P=0.009), but was not associated with DR (x2 trend=1.558, P=0.212). In the survival analysis, N stage (P=0.0251) and lymph node dissection (P=0.0073) had significant influence on LR, but not on DR or disease-specific survival. However, the number of lymph nodes harvested did not affect LR-free, DR-free, or disease-specific survival. We conclude that lymph node dissection may improve the control of locoregional cancer, as well as staging accuracy, in cN0 muscle-invasive UUT-TCC, but that it does not clearly influence survival.

Original languageEnglish
Pages (from-to)674-678
Number of pages5
JournalJournal of Korean medical science
Volume24
Issue number4
DOIs
Publication statusPublished - 2009 Aug 1

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Transitional Cell Carcinoma
Lymph Node Excision
Urinary Tract
Recurrence
Muscles
Lymph Nodes
Survival
Survival Analysis
Medical Records
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Clinical significance of lymph node dissection in patients with muscle-invasive upper urinary tract transitional cell carcinoma treated with nephroureterectomy",
abstract = "We investigated the value of lymph node dissection in patients with cN0 muscle-invasive transitional cell carcinoma of the upper urinary tract (UUT-TCC). Medical records of 152 patients with cN0 muscle-invasive UUT-TCC, who underwent nephroureterectomy between 1986 and 2005, were reviewed. Sixty-three patients (41.4{\%}) underwent lymph node dissection. The median number of lymph nodes harvested was 6 (range, 1 to 35), and from these, lymph node involvement was confirmed in 9 patients (14.3{\%}). Locoregional recurrence (LR) and disease-recurrence (DR) occurred in 29 patients and 63 patients, respectively. Fifty-five patients (36.2{\%}) had died of cancer at the last follow-up. The number of lymph nodes harvested was associated with the reduction of LR (x2 trend=6.755, P=0.009), but was not associated with DR (x2 trend=1.558, P=0.212). In the survival analysis, N stage (P=0.0251) and lymph node dissection (P=0.0073) had significant influence on LR, but not on DR or disease-specific survival. However, the number of lymph nodes harvested did not affect LR-free, DR-free, or disease-specific survival. We conclude that lymph node dissection may improve the control of locoregional cancer, as well as staging accuracy, in cN0 muscle-invasive UUT-TCC, but that it does not clearly influence survival.",
author = "Cho, {Kang Su} and Choi, {Hyun Min} and Kyochul Koo and Park, {Sung Jin} and Rha, {Koon Ho} and Choi, {Young Deuk} and Chung, {Byung Ha} and Cho, {Nam Hoon} and Yang, {Seung Choul} and Hong, {Sung Joon}",
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Clinical significance of lymph node dissection in patients with muscle-invasive upper urinary tract transitional cell carcinoma treated with nephroureterectomy. / Cho, Kang Su; Choi, Hyun Min; Koo, Kyochul; Park, Sung Jin; Rha, Koon Ho; Choi, Young Deuk; Chung, Byung Ha; Cho, Nam Hoon; Yang, Seung Choul; Hong, Sung Joon.

In: Journal of Korean medical science, Vol. 24, No. 4, 01.08.2009, p. 674-678.

Research output: Contribution to journalArticle

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AU - Cho, Kang Su

AU - Choi, Hyun Min

AU - Koo, Kyochul

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AU - Rha, Koon Ho

AU - Choi, Young Deuk

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