Clinical significance of lymph-node ratio in determining supraclavicular lymph-node radiation therapy in pn1 breast cancer patients who received breast-conserving treatment (KROG 14-18): A multicenter study

Jaeho Kim, Won Park, Jin Hee Kim, Doo Ho Choi, Yeon Joo Kim, Eun Sook Lee, Kyung Hwan Shin, Jin Ho Kim, Kyubo Kim, Yong Bae Kim, Sung Ja Ahn, Jong Hoon Lee, Mison Chun, Hyung Sik Lee, Jung Soo Kim, Jihye Cha

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Abstract

This study evaluated the clinical significance of the lymph-node ratio (LNR) and its usefulness as an indicator of supraclavicular lymph-node radiation therapy (SCNRT) in pN1 breast cancer patients with disease-free survival (DFS) outcomes. We retrospectively analyzed the clinical data of patients with pN1 breast cancer who underwent partial mastectomy and taxane-based sequential adjuvant chemotherapy with postoperative radiation therapy in 12 hospitals (n = 1121). We compared their DFS according to LNR, with a cut-off value of 0.10. The median follow-up period was 66 months (range, 3–112). Treatment failed in 73 patients (6.5%) and there was no significant difference in DFS between the SCNRT group and non-SCNRT group. High LNR (>0.10) showed significantly worse DFS in both univariate and multivariate analyses (0.010 and 0.033, respectively). In a subgroup analysis, the effect of SCNRT on DFS differed significantly among patients with LNR > 0.10 (p = 0.013). High LNR can be used as an independent prognostic factor for pN1 breast cancer patients treated with partial mastectomy and postoperative radiotherapy. It may also be useful in deciding whether to perform SCNRT to improve DFS.

Original languageEnglish
Article number680
JournalCancers
Volume11
Issue number5
DOIs
Publication statusPublished - 2019 May

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kim, J., Park, W., Kim, J. H., Choi, D. H., Kim, Y. J., Lee, E. S., Shin, K. H., Kim, J. H., Kim, K., Kim, Y. B., Ahn, S. J., Lee, J. H., Chun, M., Lee, H. S., Kim, J. S., & Cha, J. (2019). Clinical significance of lymph-node ratio in determining supraclavicular lymph-node radiation therapy in pn1 breast cancer patients who received breast-conserving treatment (KROG 14-18): A multicenter study. Cancers, 11(5), [680]. https://doi.org/10.3390/cancers11050680