Clinical significance of Mycobacterium kansasii isolates from respiratory specimens

Seong Mi Moon, Hye Yun Park, Kyeongman Jeon, Su Young Kim, Myung Jin Chung, Hee Jae Huh, Chang Seok Ki, Nam Yong Lee, Sung Jae Shin, Won Jung Koh

Research output: Contribution to journalArticle

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Abstract

The clinical significance of Mycobacterium kansasii respiratory isolates is uncertain. The aims of this study were to determine the clinical relevance of M. kansasii isolates and to identify the clinical features and outcomes of M. kansasii lung disease. We reviewed the medical records of 104 patients from whom at least one respiratory M. kansasii isolate was obtained from January 2003 to July 2014 at Samsung Medical Center, South Korea. Of these 104 patients, 54 (52%) met the diagnostic criteria for nontuberculous mycobacterial lung disease; among them, 41 (76%) patients received antibiotic treatment for a median time of 15.0 months (interquartile range [IQR], 7.0-18.0 months). The remaining 13 (24%) without overt disease progression were observed for a median period of 24.0 months (IQR, 5.0-34.5 months). Patients with M. kansasii lung disease exhibited various radiographic findings of lung disease, including the fibrocavitary form (n = 24, 44%), the nodular bronchiectatic form (n = 17, 32%), and an unclassifiable form (n = 13, 24%). The fibrocavitary form was more common in patients who received treatment (n = 23, 56%), while the nodular bronchiectatic form was more common in patients with M. kansasii lung disease who did not receive treatment (n = 9, 70%). None of the patients with a single sputum isolate (n = 18) developed M. kansasii disease over a median follow-up period of 12.0 months (IQR, 4.0-26.5 months). In total, 52% of all patients with M. kansasii respiratory isolates exhibited clinically significant disease. Moreover, patients with M. kansasii lung disease displayed diverse radiographic findings in addition to the fibrocavitary form. The nodular bronchiectatic form was more common in patients with M. kansasii lung disease with an indolent clinical course. Thus, since the clinical significance of a single M. kansasii respiratory isolate is not definite, strict adherence to recommended diagnostic criteria is advised.

Original languageEnglish
Article numbere0139621
JournalPloS one
Volume10
Issue number10
DOIs
Publication statusPublished - 2015 Oct 2

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Mycobacterium kansasii
Pulmonary diseases
respiratory tract diseases
Lung Diseases
disease course
Republic of Korea
South Korea
Anti-Bacterial Agents
Sputum

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Moon, S. M., Park, H. Y., Jeon, K., Kim, S. Y., Chung, M. J., Huh, H. J., ... Koh, W. J. (2015). Clinical significance of Mycobacterium kansasii isolates from respiratory specimens. PloS one, 10(10), [e0139621]. https://doi.org/10.1371/journal.pone.0139621
Moon, Seong Mi ; Park, Hye Yun ; Jeon, Kyeongman ; Kim, Su Young ; Chung, Myung Jin ; Huh, Hee Jae ; Ki, Chang Seok ; Lee, Nam Yong ; Shin, Sung Jae ; Koh, Won Jung. / Clinical significance of Mycobacterium kansasii isolates from respiratory specimens. In: PloS one. 2015 ; Vol. 10, No. 10.
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Moon, SM, Park, HY, Jeon, K, Kim, SY, Chung, MJ, Huh, HJ, Ki, CS, Lee, NY, Shin, SJ & Koh, WJ 2015, 'Clinical significance of Mycobacterium kansasii isolates from respiratory specimens', PloS one, vol. 10, no. 10, e0139621. https://doi.org/10.1371/journal.pone.0139621

Clinical significance of Mycobacterium kansasii isolates from respiratory specimens. / Moon, Seong Mi; Park, Hye Yun; Jeon, Kyeongman; Kim, Su Young; Chung, Myung Jin; Huh, Hee Jae; Ki, Chang Seok; Lee, Nam Yong; Shin, Sung Jae; Koh, Won Jung.

In: PloS one, Vol. 10, No. 10, e0139621, 02.10.2015.

Research output: Contribution to journalArticle

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Moon SM, Park HY, Jeon K, Kim SY, Chung MJ, Huh HJ et al. Clinical significance of Mycobacterium kansasii isolates from respiratory specimens. PloS one. 2015 Oct 2;10(10). e0139621. https://doi.org/10.1371/journal.pone.0139621