Clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary antrum

Gwi Eon Kim, Eun Ji Chung, John Jihoon Lim, Ki Chang Keum, Sang Wook Lee, Jaeho Cho, Chang Geol Lee, Eun Chang Choi

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Abstract

Purpose: To further clarify the clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary sinus (maxillary SCC). Materials and Methods: The medical charts of the 116 patients with maxillary SCC were retrospectively reviewed. Twelve patients (10.3%) presented initially with neck node metastases, and 14 (13.5%) of 104 node-negative patients subsequently developed regional recurrence during the follow-up period. The high-risk factors for neck node metastasis, patterns of regional failure, and survival for node-positive patients were analyzed with the patient cohort that had largely been treated with radiation alone. Results: Of the various factors, the tumor extension to the nasopharynx or oral cavity was the statistically significant determinants predictive of neck node metastasis at the initial diagnosis. During the follow-up period, regional failure was far less common than local failure (19.0% v 68.1%), and the majority of regional failures were accompanied by local recurrences. The oral cavity extension and control status of local disease were the high-risk factors for subsequent development of regional recurrence in node-negative patients. The overall 5-year survival rate for node-positive patients (16.7%) showed a poorer outcome compared with that for node-negative patients (31.3%), but it was similar to that of T4N0 patients (26.6%). Although patients who subsequently developed neck node recurrence during follow-up represented a dismal prognosis, uncontrolled local diseases in these patients still remained a major problem, resulting in a poor prognosis. Conclusions: Despite an unfavorable prognosis of patients with neck node metastasis, an aggressive trial to achieve maximum local control of the primary tumor was considered to be more important than elective neck treatments.

Original languageEnglish
Pages (from-to)383-390
Number of pages8
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume20
Issue number6
DOIs
Publication statusPublished - 1999 Jan 1

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Maxillary Sinus
Squamous Cell Carcinoma
Neck
Neoplasm Metastasis
Recurrence
Mouth
Nasopharynx
Neoplasms
Survival Rate
Radiation

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Kim, Gwi Eon ; Chung, Eun Ji ; Lim, John Jihoon ; Keum, Ki Chang ; Lee, Sang Wook ; Cho, Jaeho ; Lee, Chang Geol ; Choi, Eun Chang. / Clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary antrum. In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 1999 ; Vol. 20, No. 6. pp. 383-390.
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abstract = "Purpose: To further clarify the clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary sinus (maxillary SCC). Materials and Methods: The medical charts of the 116 patients with maxillary SCC were retrospectively reviewed. Twelve patients (10.3{\%}) presented initially with neck node metastases, and 14 (13.5{\%}) of 104 node-negative patients subsequently developed regional recurrence during the follow-up period. The high-risk factors for neck node metastasis, patterns of regional failure, and survival for node-positive patients were analyzed with the patient cohort that had largely been treated with radiation alone. Results: Of the various factors, the tumor extension to the nasopharynx or oral cavity was the statistically significant determinants predictive of neck node metastasis at the initial diagnosis. During the follow-up period, regional failure was far less common than local failure (19.0{\%} v 68.1{\%}), and the majority of regional failures were accompanied by local recurrences. The oral cavity extension and control status of local disease were the high-risk factors for subsequent development of regional recurrence in node-negative patients. The overall 5-year survival rate for node-positive patients (16.7{\%}) showed a poorer outcome compared with that for node-negative patients (31.3{\%}), but it was similar to that of T4N0 patients (26.6{\%}). Although patients who subsequently developed neck node recurrence during follow-up represented a dismal prognosis, uncontrolled local diseases in these patients still remained a major problem, resulting in a poor prognosis. Conclusions: Despite an unfavorable prognosis of patients with neck node metastasis, an aggressive trial to achieve maximum local control of the primary tumor was considered to be more important than elective neck treatments.",
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Clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary antrum. / Kim, Gwi Eon; Chung, Eun Ji; Lim, John Jihoon; Keum, Ki Chang; Lee, Sang Wook; Cho, Jaeho; Lee, Chang Geol; Choi, Eun Chang.

In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 20, No. 6, 01.01.1999, p. 383-390.

Research output: Contribution to journalArticle

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AU - Kim, Gwi Eon

AU - Chung, Eun Ji

AU - Lim, John Jihoon

AU - Keum, Ki Chang

AU - Lee, Sang Wook

AU - Cho, Jaeho

AU - Lee, Chang Geol

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N2 - Purpose: To further clarify the clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary sinus (maxillary SCC). Materials and Methods: The medical charts of the 116 patients with maxillary SCC were retrospectively reviewed. Twelve patients (10.3%) presented initially with neck node metastases, and 14 (13.5%) of 104 node-negative patients subsequently developed regional recurrence during the follow-up period. The high-risk factors for neck node metastasis, patterns of regional failure, and survival for node-positive patients were analyzed with the patient cohort that had largely been treated with radiation alone. Results: Of the various factors, the tumor extension to the nasopharynx or oral cavity was the statistically significant determinants predictive of neck node metastasis at the initial diagnosis. During the follow-up period, regional failure was far less common than local failure (19.0% v 68.1%), and the majority of regional failures were accompanied by local recurrences. The oral cavity extension and control status of local disease were the high-risk factors for subsequent development of regional recurrence in node-negative patients. The overall 5-year survival rate for node-positive patients (16.7%) showed a poorer outcome compared with that for node-negative patients (31.3%), but it was similar to that of T4N0 patients (26.6%). Although patients who subsequently developed neck node recurrence during follow-up represented a dismal prognosis, uncontrolled local diseases in these patients still remained a major problem, resulting in a poor prognosis. Conclusions: Despite an unfavorable prognosis of patients with neck node metastasis, an aggressive trial to achieve maximum local control of the primary tumor was considered to be more important than elective neck treatments.

AB - Purpose: To further clarify the clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary sinus (maxillary SCC). Materials and Methods: The medical charts of the 116 patients with maxillary SCC were retrospectively reviewed. Twelve patients (10.3%) presented initially with neck node metastases, and 14 (13.5%) of 104 node-negative patients subsequently developed regional recurrence during the follow-up period. The high-risk factors for neck node metastasis, patterns of regional failure, and survival for node-positive patients were analyzed with the patient cohort that had largely been treated with radiation alone. Results: Of the various factors, the tumor extension to the nasopharynx or oral cavity was the statistically significant determinants predictive of neck node metastasis at the initial diagnosis. During the follow-up period, regional failure was far less common than local failure (19.0% v 68.1%), and the majority of regional failures were accompanied by local recurrences. The oral cavity extension and control status of local disease were the high-risk factors for subsequent development of regional recurrence in node-negative patients. The overall 5-year survival rate for node-positive patients (16.7%) showed a poorer outcome compared with that for node-negative patients (31.3%), but it was similar to that of T4N0 patients (26.6%). Although patients who subsequently developed neck node recurrence during follow-up represented a dismal prognosis, uncontrolled local diseases in these patients still remained a major problem, resulting in a poor prognosis. Conclusions: Despite an unfavorable prognosis of patients with neck node metastasis, an aggressive trial to achieve maximum local control of the primary tumor was considered to be more important than elective neck treatments.

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