Clinical significance of peripheral zone thickness in men with lower urinary tract symptoms/benign prostatic hyperplasia

Jong Kyou Kwon, Jang Hee Han, Ho Chul Choi, Dong Hyuk Kang, Joo Yong Lee, Jae Heon Kim, Cheol Kyu Oh, Youngdeuk Choi, Kang Su Cho

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective To evaluate the clinical impact of prostate peripheral zone thickness (PZT), based on presumed circle area ratio (PCAR) theory, on urinary symptoms in men with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) as a novel prostate parameter. Patients and methods Medical records were obtained from a prospective database of first-visit men with LUTS/BPH. Age, international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), maximum urinary flow rate (Q max ), and post-void residual urine volume (PVR) were assessed. Total prostate volume (TPV), transition zone volume (TZV), transition zone index (TZI), and PZT were measured by transrectal ultrasonography. Reliability analysis was also performed. Results In all, 1009 patients were enrolled for the analysis. The mean (sd) PZT was 11.10 (2.50) mm, and patients were classified into three groups PZT thickness groups; PZT <9.5 mm, ≥9.5 to <13 mm, and ≥13 mm. As the PZT became smaller, all urinary symptom scores including IPSS, quality of life (QoL), and OABSS significantly increased. Uroflowmetry variables, such as Q max and PVR, also showed significant differences. PZT showed a high intra-class correlation coefficient (0.896). Multivariate analysis revealed that the PZT was independently associated with IPSS (P < 0.001), QoL (P = 0.003), OABSS (P = 0.001), and PVR (P = 0.001), but PZT influence on Q max was only of borderline significance (P = 0.055). Conclusion PZT is a novel, easy-to-measure prostate parameter that is significantly associated with urinary symptoms. Our present findings suggest that clinical usefulness of PZT should be further validated for managing men with LUTS/BPH.

Original languageEnglish
Pages (from-to)316-322
Number of pages7
JournalBJU International
Volume117
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

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Lower Urinary Tract Symptoms
Prostatic Hyperplasia
Prostate
Overactive Urinary Bladder
Quality of Life
Residual Volume
Medical Records
Ultrasonography
Multivariate Analysis
Urine
Databases

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Kwon, J. K., Han, J. H., Choi, H. C., Kang, D. H., Lee, J. Y., Kim, J. H., ... Cho, K. S. (2016). Clinical significance of peripheral zone thickness in men with lower urinary tract symptoms/benign prostatic hyperplasia. BJU International, 117(2), 316-322. https://doi.org/10.1111/bju.13130
Kwon, Jong Kyou ; Han, Jang Hee ; Choi, Ho Chul ; Kang, Dong Hyuk ; Lee, Joo Yong ; Kim, Jae Heon ; Oh, Cheol Kyu ; Choi, Youngdeuk ; Cho, Kang Su. / Clinical significance of peripheral zone thickness in men with lower urinary tract symptoms/benign prostatic hyperplasia. In: BJU International. 2016 ; Vol. 117, No. 2. pp. 316-322.
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abstract = "Objective To evaluate the clinical impact of prostate peripheral zone thickness (PZT), based on presumed circle area ratio (PCAR) theory, on urinary symptoms in men with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) as a novel prostate parameter. Patients and methods Medical records were obtained from a prospective database of first-visit men with LUTS/BPH. Age, international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), maximum urinary flow rate (Q max ), and post-void residual urine volume (PVR) were assessed. Total prostate volume (TPV), transition zone volume (TZV), transition zone index (TZI), and PZT were measured by transrectal ultrasonography. Reliability analysis was also performed. Results In all, 1009 patients were enrolled for the analysis. The mean (sd) PZT was 11.10 (2.50) mm, and patients were classified into three groups PZT thickness groups; PZT <9.5 mm, ≥9.5 to <13 mm, and ≥13 mm. As the PZT became smaller, all urinary symptom scores including IPSS, quality of life (QoL), and OABSS significantly increased. Uroflowmetry variables, such as Q max and PVR, also showed significant differences. PZT showed a high intra-class correlation coefficient (0.896). Multivariate analysis revealed that the PZT was independently associated with IPSS (P < 0.001), QoL (P = 0.003), OABSS (P = 0.001), and PVR (P = 0.001), but PZT influence on Q max was only of borderline significance (P = 0.055). Conclusion PZT is a novel, easy-to-measure prostate parameter that is significantly associated with urinary symptoms. Our present findings suggest that clinical usefulness of PZT should be further validated for managing men with LUTS/BPH.",
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Clinical significance of peripheral zone thickness in men with lower urinary tract symptoms/benign prostatic hyperplasia. / Kwon, Jong Kyou; Han, Jang Hee; Choi, Ho Chul; Kang, Dong Hyuk; Lee, Joo Yong; Kim, Jae Heon; Oh, Cheol Kyu; Choi, Youngdeuk; Cho, Kang Su.

In: BJU International, Vol. 117, No. 2, 01.02.2016, p. 316-322.

Research output: Contribution to journalArticle

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T1 - Clinical significance of peripheral zone thickness in men with lower urinary tract symptoms/benign prostatic hyperplasia

AU - Kwon, Jong Kyou

AU - Han, Jang Hee

AU - Choi, Ho Chul

AU - Kang, Dong Hyuk

AU - Lee, Joo Yong

AU - Kim, Jae Heon

AU - Oh, Cheol Kyu

AU - Choi, Youngdeuk

AU - Cho, Kang Su

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N2 - Objective To evaluate the clinical impact of prostate peripheral zone thickness (PZT), based on presumed circle area ratio (PCAR) theory, on urinary symptoms in men with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) as a novel prostate parameter. Patients and methods Medical records were obtained from a prospective database of first-visit men with LUTS/BPH. Age, international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), maximum urinary flow rate (Q max ), and post-void residual urine volume (PVR) were assessed. Total prostate volume (TPV), transition zone volume (TZV), transition zone index (TZI), and PZT were measured by transrectal ultrasonography. Reliability analysis was also performed. Results In all, 1009 patients were enrolled for the analysis. The mean (sd) PZT was 11.10 (2.50) mm, and patients were classified into three groups PZT thickness groups; PZT <9.5 mm, ≥9.5 to <13 mm, and ≥13 mm. As the PZT became smaller, all urinary symptom scores including IPSS, quality of life (QoL), and OABSS significantly increased. Uroflowmetry variables, such as Q max and PVR, also showed significant differences. PZT showed a high intra-class correlation coefficient (0.896). Multivariate analysis revealed that the PZT was independently associated with IPSS (P < 0.001), QoL (P = 0.003), OABSS (P = 0.001), and PVR (P = 0.001), but PZT influence on Q max was only of borderline significance (P = 0.055). Conclusion PZT is a novel, easy-to-measure prostate parameter that is significantly associated with urinary symptoms. Our present findings suggest that clinical usefulness of PZT should be further validated for managing men with LUTS/BPH.

AB - Objective To evaluate the clinical impact of prostate peripheral zone thickness (PZT), based on presumed circle area ratio (PCAR) theory, on urinary symptoms in men with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) as a novel prostate parameter. Patients and methods Medical records were obtained from a prospective database of first-visit men with LUTS/BPH. Age, international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), maximum urinary flow rate (Q max ), and post-void residual urine volume (PVR) were assessed. Total prostate volume (TPV), transition zone volume (TZV), transition zone index (TZI), and PZT were measured by transrectal ultrasonography. Reliability analysis was also performed. Results In all, 1009 patients were enrolled for the analysis. The mean (sd) PZT was 11.10 (2.50) mm, and patients were classified into three groups PZT thickness groups; PZT <9.5 mm, ≥9.5 to <13 mm, and ≥13 mm. As the PZT became smaller, all urinary symptom scores including IPSS, quality of life (QoL), and OABSS significantly increased. Uroflowmetry variables, such as Q max and PVR, also showed significant differences. PZT showed a high intra-class correlation coefficient (0.896). Multivariate analysis revealed that the PZT was independently associated with IPSS (P < 0.001), QoL (P = 0.003), OABSS (P = 0.001), and PVR (P = 0.001), but PZT influence on Q max was only of borderline significance (P = 0.055). Conclusion PZT is a novel, easy-to-measure prostate parameter that is significantly associated with urinary symptoms. Our present findings suggest that clinical usefulness of PZT should be further validated for managing men with LUTS/BPH.

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