Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis

Min Sung Kim, Minkyu Chung, Joong Bae Ahn, Chang Woo Kim, Min Soo Cho, Sang Joon Shin, Se Jin Baek, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Namkyu Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background The aim of this study was to compare the outcomes in colorectal cancer (CRC) patients with synchronous unresectable metastases who received either primary tumor resection (PTR) or chemotherapy as the first treatment and to investigate the clinical course of asymptomatic patients who received chemotherapy as the first treatment. Methods We retrospectively analyzed 324 CRC patients with synchronous unresectable metastases. Overall survival (OS) was analyzed for the two groups (upfront PTR group [n = 72] vs. upfront chemotherapy group [n = 252]). Surgical morbidity and mortality were recorded. In the asymptomatic patients who received upfront chemotherapy, the incidences of primary tumor-related complications were analyzed. Results In patients who underwent PTR as the first treatment, the median OS period was superior to those who received upfront chemotherapy (17.2 vs. 13.6 months, P = 0.002). In the PTR group, surgical morbidity and mortality were 11.6% and 1.9%, respectively. Of the 252 asymptomatic patients, the incidence of primary tumor-related complications was 35%. Emergent surgery was ultimately done in 14% of the 252 patients. Conclusion CRC patients with synchronous unresectable metastases who underwent PTR followed by chemotherapy had significantly longer survival times compared to patients who received chemotherapy as the first treatment.

Original languageEnglish
Pages (from-to)214-221
Number of pages8
JournalJournal of Surgical Oncology
Volume110
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

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Colorectal Neoplasms
Neoplasm Metastasis
Drug Therapy
Neoplasms
Survival
Morbidity
Mortality
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Kim, Min Sung ; Chung, Minkyu ; Ahn, Joong Bae ; Kim, Chang Woo ; Cho, Min Soo ; Shin, Sang Joon ; Baek, Se Jin ; Hur, Hyuk ; Min, Byung Soh ; Baik, Seung Hyuk ; Kim, Namkyu. / Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis. In: Journal of Surgical Oncology. 2014 ; Vol. 110, No. 2. pp. 214-221.
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abstract = "Background The aim of this study was to compare the outcomes in colorectal cancer (CRC) patients with synchronous unresectable metastases who received either primary tumor resection (PTR) or chemotherapy as the first treatment and to investigate the clinical course of asymptomatic patients who received chemotherapy as the first treatment. Methods We retrospectively analyzed 324 CRC patients with synchronous unresectable metastases. Overall survival (OS) was analyzed for the two groups (upfront PTR group [n = 72] vs. upfront chemotherapy group [n = 252]). Surgical morbidity and mortality were recorded. In the asymptomatic patients who received upfront chemotherapy, the incidences of primary tumor-related complications were analyzed. Results In patients who underwent PTR as the first treatment, the median OS period was superior to those who received upfront chemotherapy (17.2 vs. 13.6 months, P = 0.002). In the PTR group, surgical morbidity and mortality were 11.6{\%} and 1.9{\%}, respectively. Of the 252 asymptomatic patients, the incidence of primary tumor-related complications was 35{\%}. Emergent surgery was ultimately done in 14{\%} of the 252 patients. Conclusion CRC patients with synchronous unresectable metastases who underwent PTR followed by chemotherapy had significantly longer survival times compared to patients who received chemotherapy as the first treatment.",
author = "Kim, {Min Sung} and Minkyu Chung and Ahn, {Joong Bae} and Kim, {Chang Woo} and Cho, {Min Soo} and Shin, {Sang Joon} and Baek, {Se Jin} and Hyuk Hur and Min, {Byung Soh} and Baik, {Seung Hyuk} and Namkyu Kim",
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Kim, MS, Chung, M, Ahn, JB, Kim, CW, Cho, MS, Shin, SJ, Baek, SJ, Hur, H, Min, BS, Baik, SH & Kim, N 2014, 'Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis', Journal of Surgical Oncology, vol. 110, no. 2, pp. 214-221. https://doi.org/10.1002/jso.23607

Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis. / Kim, Min Sung; Chung, Minkyu; Ahn, Joong Bae; Kim, Chang Woo; Cho, Min Soo; Shin, Sang Joon; Baek, Se Jin; Hur, Hyuk; Min, Byung Soh; Baik, Seung Hyuk; Kim, Namkyu.

In: Journal of Surgical Oncology, Vol. 110, No. 2, 01.01.2014, p. 214-221.

Research output: Contribution to journalArticle

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T1 - Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis

AU - Kim, Min Sung

AU - Chung, Minkyu

AU - Ahn, Joong Bae

AU - Kim, Chang Woo

AU - Cho, Min Soo

AU - Shin, Sang Joon

AU - Baek, Se Jin

AU - Hur, Hyuk

AU - Min, Byung Soh

AU - Baik, Seung Hyuk

AU - Kim, Namkyu

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Y1 - 2014/1/1

N2 - Background The aim of this study was to compare the outcomes in colorectal cancer (CRC) patients with synchronous unresectable metastases who received either primary tumor resection (PTR) or chemotherapy as the first treatment and to investigate the clinical course of asymptomatic patients who received chemotherapy as the first treatment. Methods We retrospectively analyzed 324 CRC patients with synchronous unresectable metastases. Overall survival (OS) was analyzed for the two groups (upfront PTR group [n = 72] vs. upfront chemotherapy group [n = 252]). Surgical morbidity and mortality were recorded. In the asymptomatic patients who received upfront chemotherapy, the incidences of primary tumor-related complications were analyzed. Results In patients who underwent PTR as the first treatment, the median OS period was superior to those who received upfront chemotherapy (17.2 vs. 13.6 months, P = 0.002). In the PTR group, surgical morbidity and mortality were 11.6% and 1.9%, respectively. Of the 252 asymptomatic patients, the incidence of primary tumor-related complications was 35%. Emergent surgery was ultimately done in 14% of the 252 patients. Conclusion CRC patients with synchronous unresectable metastases who underwent PTR followed by chemotherapy had significantly longer survival times compared to patients who received chemotherapy as the first treatment.

AB - Background The aim of this study was to compare the outcomes in colorectal cancer (CRC) patients with synchronous unresectable metastases who received either primary tumor resection (PTR) or chemotherapy as the first treatment and to investigate the clinical course of asymptomatic patients who received chemotherapy as the first treatment. Methods We retrospectively analyzed 324 CRC patients with synchronous unresectable metastases. Overall survival (OS) was analyzed for the two groups (upfront PTR group [n = 72] vs. upfront chemotherapy group [n = 252]). Surgical morbidity and mortality were recorded. In the asymptomatic patients who received upfront chemotherapy, the incidences of primary tumor-related complications were analyzed. Results In patients who underwent PTR as the first treatment, the median OS period was superior to those who received upfront chemotherapy (17.2 vs. 13.6 months, P = 0.002). In the PTR group, surgical morbidity and mortality were 11.6% and 1.9%, respectively. Of the 252 asymptomatic patients, the incidence of primary tumor-related complications was 35%. Emergent surgery was ultimately done in 14% of the 252 patients. Conclusion CRC patients with synchronous unresectable metastases who underwent PTR followed by chemotherapy had significantly longer survival times compared to patients who received chemotherapy as the first treatment.

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