Clinical significance of squamous differentiation in bladder transitional cell carcinoma

Kang Su Cho, Won Jae Yang, Namhoon Cho, Hyo Sup Shim, Sung Joon Hong, Youngdeuk Choi

Research output: Contribution to journalArticle

Abstract

Purpose: We evaluated the clinicopathological characteristics and clinical significance of squamous differentiation in bladder transitional cell carcinoma (TCCa). Materials and methods: Between 1993 and 2002, the medical records of 38 patients, who revealed squamous differentiation in bladder TCCa, were retrospectively analyzed with regard to their clinicopathological characteristics. The mean age and follow-up were 64.8 years (52-83) and 31.2 months (6-86), respectively. Results: On cystoscopic examination, 68.4% (26 patients) were larger than 3cm in size, 63.2% (24 patients) non-papillary or mixed pattern and 68.4% (26 patients) multiple tumors comprised of more than 3. Histologically, the bladder TCCa, with squamous differentiation, were grade III in 89.5% (34 patients), and showed muscle proper invasion in 60.5% (23 patients). In a superficial bladder TCCa with squamous differentiation, the cancer tended to be multiple, more than 3 (80.0%), despite a size smaller than 3cm (66.7%). Of 15 patients with superficial cancer, recurrences were observed in 10 during follow-up, and in 7 (70.0%) revealing muscle proper invasion. The five-year recurrence and progression free survival were 23.9 and 36.9%, respectively. In invasive bladder TCCa with squamous differentiation, the cancer tended to have tumors larger than 3cm (91.3%). The five-year survival rate was 28.5% for invasive bladder cancer. Conclusions: Squamous differentiation in bladder TCCa was associated with high grade and invasive bladder cancer. Superficial bladder TCCa with squamous differentiation tended to be multiple, and showed high recurrence and progression rates. Invasive bladder TCCa with squamous differentiation tended to be large and show a poor prognosis.

Original languageEnglish
Pages (from-to)336-340
Number of pages5
JournalKorean Journal of Urology
Volume46
Issue number4
Publication statusPublished - 2005 Apr 1

Fingerprint

Transitional Cell Carcinoma
Urinary Bladder
Neoplasms
Urinary Bladder Neoplasms
Recurrence
Muscles
Disease-Free Survival
Medical Records
Survival Rate

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Cho, Kang Su ; Yang, Won Jae ; Cho, Namhoon ; Shim, Hyo Sup ; Hong, Sung Joon ; Choi, Youngdeuk. / Clinical significance of squamous differentiation in bladder transitional cell carcinoma. In: Korean Journal of Urology. 2005 ; Vol. 46, No. 4. pp. 336-340.
@article{0d3b4e0be3744e2e8d4cdda8a8ba8fd9,
title = "Clinical significance of squamous differentiation in bladder transitional cell carcinoma",
abstract = "Purpose: We evaluated the clinicopathological characteristics and clinical significance of squamous differentiation in bladder transitional cell carcinoma (TCCa). Materials and methods: Between 1993 and 2002, the medical records of 38 patients, who revealed squamous differentiation in bladder TCCa, were retrospectively analyzed with regard to their clinicopathological characteristics. The mean age and follow-up were 64.8 years (52-83) and 31.2 months (6-86), respectively. Results: On cystoscopic examination, 68.4{\%} (26 patients) were larger than 3cm in size, 63.2{\%} (24 patients) non-papillary or mixed pattern and 68.4{\%} (26 patients) multiple tumors comprised of more than 3. Histologically, the bladder TCCa, with squamous differentiation, were grade III in 89.5{\%} (34 patients), and showed muscle proper invasion in 60.5{\%} (23 patients). In a superficial bladder TCCa with squamous differentiation, the cancer tended to be multiple, more than 3 (80.0{\%}), despite a size smaller than 3cm (66.7{\%}). Of 15 patients with superficial cancer, recurrences were observed in 10 during follow-up, and in 7 (70.0{\%}) revealing muscle proper invasion. The five-year recurrence and progression free survival were 23.9 and 36.9{\%}, respectively. In invasive bladder TCCa with squamous differentiation, the cancer tended to have tumors larger than 3cm (91.3{\%}). The five-year survival rate was 28.5{\%} for invasive bladder cancer. Conclusions: Squamous differentiation in bladder TCCa was associated with high grade and invasive bladder cancer. Superficial bladder TCCa with squamous differentiation tended to be multiple, and showed high recurrence and progression rates. Invasive bladder TCCa with squamous differentiation tended to be large and show a poor prognosis.",
author = "Cho, {Kang Su} and Yang, {Won Jae} and Namhoon Cho and Shim, {Hyo Sup} and Hong, {Sung Joon} and Youngdeuk Choi",
year = "2005",
month = "4",
day = "1",
language = "English",
volume = "46",
pages = "336--340",
journal = "Korean Journal of Urology",
issn = "2005-6737",
publisher = "Korean Urological Association",
number = "4",

}

Clinical significance of squamous differentiation in bladder transitional cell carcinoma. / Cho, Kang Su; Yang, Won Jae; Cho, Namhoon; Shim, Hyo Sup; Hong, Sung Joon; Choi, Youngdeuk.

In: Korean Journal of Urology, Vol. 46, No. 4, 01.04.2005, p. 336-340.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical significance of squamous differentiation in bladder transitional cell carcinoma

AU - Cho, Kang Su

AU - Yang, Won Jae

AU - Cho, Namhoon

AU - Shim, Hyo Sup

AU - Hong, Sung Joon

AU - Choi, Youngdeuk

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Purpose: We evaluated the clinicopathological characteristics and clinical significance of squamous differentiation in bladder transitional cell carcinoma (TCCa). Materials and methods: Between 1993 and 2002, the medical records of 38 patients, who revealed squamous differentiation in bladder TCCa, were retrospectively analyzed with regard to their clinicopathological characteristics. The mean age and follow-up were 64.8 years (52-83) and 31.2 months (6-86), respectively. Results: On cystoscopic examination, 68.4% (26 patients) were larger than 3cm in size, 63.2% (24 patients) non-papillary or mixed pattern and 68.4% (26 patients) multiple tumors comprised of more than 3. Histologically, the bladder TCCa, with squamous differentiation, were grade III in 89.5% (34 patients), and showed muscle proper invasion in 60.5% (23 patients). In a superficial bladder TCCa with squamous differentiation, the cancer tended to be multiple, more than 3 (80.0%), despite a size smaller than 3cm (66.7%). Of 15 patients with superficial cancer, recurrences were observed in 10 during follow-up, and in 7 (70.0%) revealing muscle proper invasion. The five-year recurrence and progression free survival were 23.9 and 36.9%, respectively. In invasive bladder TCCa with squamous differentiation, the cancer tended to have tumors larger than 3cm (91.3%). The five-year survival rate was 28.5% for invasive bladder cancer. Conclusions: Squamous differentiation in bladder TCCa was associated with high grade and invasive bladder cancer. Superficial bladder TCCa with squamous differentiation tended to be multiple, and showed high recurrence and progression rates. Invasive bladder TCCa with squamous differentiation tended to be large and show a poor prognosis.

AB - Purpose: We evaluated the clinicopathological characteristics and clinical significance of squamous differentiation in bladder transitional cell carcinoma (TCCa). Materials and methods: Between 1993 and 2002, the medical records of 38 patients, who revealed squamous differentiation in bladder TCCa, were retrospectively analyzed with regard to their clinicopathological characteristics. The mean age and follow-up were 64.8 years (52-83) and 31.2 months (6-86), respectively. Results: On cystoscopic examination, 68.4% (26 patients) were larger than 3cm in size, 63.2% (24 patients) non-papillary or mixed pattern and 68.4% (26 patients) multiple tumors comprised of more than 3. Histologically, the bladder TCCa, with squamous differentiation, were grade III in 89.5% (34 patients), and showed muscle proper invasion in 60.5% (23 patients). In a superficial bladder TCCa with squamous differentiation, the cancer tended to be multiple, more than 3 (80.0%), despite a size smaller than 3cm (66.7%). Of 15 patients with superficial cancer, recurrences were observed in 10 during follow-up, and in 7 (70.0%) revealing muscle proper invasion. The five-year recurrence and progression free survival were 23.9 and 36.9%, respectively. In invasive bladder TCCa with squamous differentiation, the cancer tended to have tumors larger than 3cm (91.3%). The five-year survival rate was 28.5% for invasive bladder cancer. Conclusions: Squamous differentiation in bladder TCCa was associated with high grade and invasive bladder cancer. Superficial bladder TCCa with squamous differentiation tended to be multiple, and showed high recurrence and progression rates. Invasive bladder TCCa with squamous differentiation tended to be large and show a poor prognosis.

UR - http://www.scopus.com/inward/record.url?scp=20444379253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444379253&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:20444379253

VL - 46

SP - 336

EP - 340

JO - Korean Journal of Urology

JF - Korean Journal of Urology

SN - 2005-6737

IS - 4

ER -