Clinical spectrum of reflux esophagitis among 25,536 Koreans who underwent a health check-up: A nationwide multicenter prospective, endoscopy-based Study

Ki Nam Shim, Su Jin Hong, Jae Kyu Sung, Kyung Sik Park, Seong Eun Kim, Hyun Shin Park, Young Sun Kim, Seon Hee Lim, Chung Hyeon Kim, Min Jung Park, Jeong Yoon Yim, Kyung Ran Cho, Donghee Kim, Seun Ja Park, Sam Ryong Jee, Jin Il Kim, Joon Yong Park, Geun Am Song, Hwoon Yong Jung, Yong Chan LeeJae Gyu Kim, Jae J. Kim, Nayoung Kim, Soo Heon Park, Hyun Chae Jung, In Sik Chung

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Abstract

Background: Gastroesophageal reflux is a commonly encountered condition, but detailed data on reflux symptoms in Asian countries are lacking. Goals: To evaluate the prevalence and to document the clinical spectrum of endoscopic reflux esophagitis (RE). Study: A total 25,536 subjects underwent an upper gastrointestinal endoscopic examination as part of a health check, and completed a gastroesophageal reflux questionnaire. Endoscopic findings classified according to the Los Angeles (LA) classification and the data from gastroesophageal reflux questionnaire were analyzed. Results: On the basis of endoscopic findings, 2019 subjects (7.91%) were found to have RE: 5.87% in LA-A; 1.84% in LA-B; 0.18% in LA-C; and 0.02% in LA-D. Heartburn, acid regurgitation, chest pain, hoarseness, globus sensation, cough, and epigastric soreness were found to be associated with RE (P<0.05). Heartburn, acid regurgitation, and epigastric soreness were more frequent in LA-B than in LA-A (P<0.05). Epigastric soreness was most bothersome in LA-A and LA-B, and acid regurgitation was most bothersome in LA-C and LA-D (P<0.01). Heartburn, hoarseness, and globus sensation were more frequent in men with RE, and acid regurgitation was most common in women. Conclusions: The prevalence of RE was found to be 7.91% in Korea, and the profiles of reflux symptoms were found to depend on grade of RE and sex.

Original languageEnglish
Pages (from-to)632-638
Number of pages7
JournalJournal of Clinical Gastroenterology
Volume43
Issue number7
DOIs
Publication statusPublished - 2009 Aug 1

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Peptic Esophagitis
Los Angeles
Endoscopy
Health
Heartburn
Gastroesophageal Reflux
Hoarseness
Acids
Korea
Chest Pain
Cough

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Shim, Ki Nam ; Hong, Su Jin ; Sung, Jae Kyu ; Park, Kyung Sik ; Kim, Seong Eun ; Park, Hyun Shin ; Kim, Young Sun ; Lim, Seon Hee ; Kim, Chung Hyeon ; Park, Min Jung ; Yim, Jeong Yoon ; Cho, Kyung Ran ; Kim, Donghee ; Park, Seun Ja ; Jee, Sam Ryong ; Kim, Jin Il ; Park, Joon Yong ; Song, Geun Am ; Jung, Hwoon Yong ; Lee, Yong Chan ; Kim, Jae Gyu ; Kim, Jae J. ; Kim, Nayoung ; Park, Soo Heon ; Jung, Hyun Chae ; Chung, In Sik. / Clinical spectrum of reflux esophagitis among 25,536 Koreans who underwent a health check-up : A nationwide multicenter prospective, endoscopy-based Study. In: Journal of Clinical Gastroenterology. 2009 ; Vol. 43, No. 7. pp. 632-638.
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title = "Clinical spectrum of reflux esophagitis among 25,536 Koreans who underwent a health check-up: A nationwide multicenter prospective, endoscopy-based Study",
abstract = "Background: Gastroesophageal reflux is a commonly encountered condition, but detailed data on reflux symptoms in Asian countries are lacking. Goals: To evaluate the prevalence and to document the clinical spectrum of endoscopic reflux esophagitis (RE). Study: A total 25,536 subjects underwent an upper gastrointestinal endoscopic examination as part of a health check, and completed a gastroesophageal reflux questionnaire. Endoscopic findings classified according to the Los Angeles (LA) classification and the data from gastroesophageal reflux questionnaire were analyzed. Results: On the basis of endoscopic findings, 2019 subjects (7.91{\%}) were found to have RE: 5.87{\%} in LA-A; 1.84{\%} in LA-B; 0.18{\%} in LA-C; and 0.02{\%} in LA-D. Heartburn, acid regurgitation, chest pain, hoarseness, globus sensation, cough, and epigastric soreness were found to be associated with RE (P<0.05). Heartburn, acid regurgitation, and epigastric soreness were more frequent in LA-B than in LA-A (P<0.05). Epigastric soreness was most bothersome in LA-A and LA-B, and acid regurgitation was most bothersome in LA-C and LA-D (P<0.01). Heartburn, hoarseness, and globus sensation were more frequent in men with RE, and acid regurgitation was most common in women. Conclusions: The prevalence of RE was found to be 7.91{\%} in Korea, and the profiles of reflux symptoms were found to depend on grade of RE and sex.",
author = "Shim, {Ki Nam} and Hong, {Su Jin} and Sung, {Jae Kyu} and Park, {Kyung Sik} and Kim, {Seong Eun} and Park, {Hyun Shin} and Kim, {Young Sun} and Lim, {Seon Hee} and Kim, {Chung Hyeon} and Park, {Min Jung} and Yim, {Jeong Yoon} and Cho, {Kyung Ran} and Donghee Kim and Park, {Seun Ja} and Jee, {Sam Ryong} and Kim, {Jin Il} and Park, {Joon Yong} and Song, {Geun Am} and Jung, {Hwoon Yong} and Lee, {Yong Chan} and Kim, {Jae Gyu} and Kim, {Jae J.} and Nayoung Kim and Park, {Soo Heon} and Jung, {Hyun Chae} and Chung, {In Sik}",
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Shim, KN, Hong, SJ, Sung, JK, Park, KS, Kim, SE, Park, HS, Kim, YS, Lim, SH, Kim, CH, Park, MJ, Yim, JY, Cho, KR, Kim, D, Park, SJ, Jee, SR, Kim, JI, Park, JY, Song, GA, Jung, HY, Lee, YC, Kim, JG, Kim, JJ, Kim, N, Park, SH, Jung, HC & Chung, IS 2009, 'Clinical spectrum of reflux esophagitis among 25,536 Koreans who underwent a health check-up: A nationwide multicenter prospective, endoscopy-based Study', Journal of Clinical Gastroenterology, vol. 43, no. 7, pp. 632-638. https://doi.org/10.1097/MCG.0b013e3181855055

Clinical spectrum of reflux esophagitis among 25,536 Koreans who underwent a health check-up : A nationwide multicenter prospective, endoscopy-based Study. / Shim, Ki Nam; Hong, Su Jin; Sung, Jae Kyu; Park, Kyung Sik; Kim, Seong Eun; Park, Hyun Shin; Kim, Young Sun; Lim, Seon Hee; Kim, Chung Hyeon; Park, Min Jung; Yim, Jeong Yoon; Cho, Kyung Ran; Kim, Donghee; Park, Seun Ja; Jee, Sam Ryong; Kim, Jin Il; Park, Joon Yong; Song, Geun Am; Jung, Hwoon Yong; Lee, Yong Chan; Kim, Jae Gyu; Kim, Jae J.; Kim, Nayoung; Park, Soo Heon; Jung, Hyun Chae; Chung, In Sik.

In: Journal of Clinical Gastroenterology, Vol. 43, No. 7, 01.08.2009, p. 632-638.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical spectrum of reflux esophagitis among 25,536 Koreans who underwent a health check-up

T2 - A nationwide multicenter prospective, endoscopy-based Study

AU - Shim, Ki Nam

AU - Hong, Su Jin

AU - Sung, Jae Kyu

AU - Park, Kyung Sik

AU - Kim, Seong Eun

AU - Park, Hyun Shin

AU - Kim, Young Sun

AU - Lim, Seon Hee

AU - Kim, Chung Hyeon

AU - Park, Min Jung

AU - Yim, Jeong Yoon

AU - Cho, Kyung Ran

AU - Kim, Donghee

AU - Park, Seun Ja

AU - Jee, Sam Ryong

AU - Kim, Jin Il

AU - Park, Joon Yong

AU - Song, Geun Am

AU - Jung, Hwoon Yong

AU - Lee, Yong Chan

AU - Kim, Jae Gyu

AU - Kim, Jae J.

AU - Kim, Nayoung

AU - Park, Soo Heon

AU - Jung, Hyun Chae

AU - Chung, In Sik

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background: Gastroesophageal reflux is a commonly encountered condition, but detailed data on reflux symptoms in Asian countries are lacking. Goals: To evaluate the prevalence and to document the clinical spectrum of endoscopic reflux esophagitis (RE). Study: A total 25,536 subjects underwent an upper gastrointestinal endoscopic examination as part of a health check, and completed a gastroesophageal reflux questionnaire. Endoscopic findings classified according to the Los Angeles (LA) classification and the data from gastroesophageal reflux questionnaire were analyzed. Results: On the basis of endoscopic findings, 2019 subjects (7.91%) were found to have RE: 5.87% in LA-A; 1.84% in LA-B; 0.18% in LA-C; and 0.02% in LA-D. Heartburn, acid regurgitation, chest pain, hoarseness, globus sensation, cough, and epigastric soreness were found to be associated with RE (P<0.05). Heartburn, acid regurgitation, and epigastric soreness were more frequent in LA-B than in LA-A (P<0.05). Epigastric soreness was most bothersome in LA-A and LA-B, and acid regurgitation was most bothersome in LA-C and LA-D (P<0.01). Heartburn, hoarseness, and globus sensation were more frequent in men with RE, and acid regurgitation was most common in women. Conclusions: The prevalence of RE was found to be 7.91% in Korea, and the profiles of reflux symptoms were found to depend on grade of RE and sex.

AB - Background: Gastroesophageal reflux is a commonly encountered condition, but detailed data on reflux symptoms in Asian countries are lacking. Goals: To evaluate the prevalence and to document the clinical spectrum of endoscopic reflux esophagitis (RE). Study: A total 25,536 subjects underwent an upper gastrointestinal endoscopic examination as part of a health check, and completed a gastroesophageal reflux questionnaire. Endoscopic findings classified according to the Los Angeles (LA) classification and the data from gastroesophageal reflux questionnaire were analyzed. Results: On the basis of endoscopic findings, 2019 subjects (7.91%) were found to have RE: 5.87% in LA-A; 1.84% in LA-B; 0.18% in LA-C; and 0.02% in LA-D. Heartburn, acid regurgitation, chest pain, hoarseness, globus sensation, cough, and epigastric soreness were found to be associated with RE (P<0.05). Heartburn, acid regurgitation, and epigastric soreness were more frequent in LA-B than in LA-A (P<0.05). Epigastric soreness was most bothersome in LA-A and LA-B, and acid regurgitation was most bothersome in LA-C and LA-D (P<0.01). Heartburn, hoarseness, and globus sensation were more frequent in men with RE, and acid regurgitation was most common in women. Conclusions: The prevalence of RE was found to be 7.91% in Korea, and the profiles of reflux symptoms were found to depend on grade of RE and sex.

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DO - 10.1097/MCG.0b013e3181855055

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