Clinicopathologic analysis of gastrointestinal stromal tumors of the colon and rectum

Sung Hoon Choi, Seo Jeon Kim, Yun Jung Choi, Byung So Min, Jin Su Kim, Seung Hyuk Baik, Namkyu Kim, Jung Gu Kang

Research output: Contribution to journalArticle

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Abstract

Purpose: This study's aim is to investigate the clinicopathologic characteristics of colorectal gastrointestinal stromal tumors (GISTs) and to evaluate the result of those tumors. Methods: We retrospectively reviewed 22 patients who had been diagnosed with primary colorectal GISTs and who had undergone a surgical resection between October 1996 and July 2008. Results: Colorectal GISTs accounted for 0.28% of all colorectal malignancies and 7.7% of all GISTs. Rectal GISTs (19, 86.4%) were more common than colonic GISTs (3, 13.6%). According to the National Institute of Health's (NIH) grading system, there were 1 (4.5%) very low, 5 (22.7%) low, 4 (18.2%) intermediate, and 12 (54.6%) high-risk tumors. The disease recurred in 7 patients (1 with intermediate risk and 6 with high risk). Recurrence sites were the liver (42.9%), the peritoneum (71.5%), and the lymph nodes (14.3%). Adjuvant imatinib therapy and/or radiation therapy were done for patients with microscopically positive margins of resection and high risk, of which one experienced a recurrence at 95 months after surgery. The five-year recurrence rates were 0% in the very-low-grade and low-grade groups, 33.3% in the intermediate-grade group, and 37.5% in the high-grade group. The five-year overall survival rates were 100% in the very-low-grade and low-grade groups, 66.7% in the intermediate-grade group, and 62.5% in the high-grade group. Conclusion: Poor prognosis of colorectal GISTs was closely related to the tumor's histologic grade and size. Integrating surgery, molecular therapy, and radiation therapy might improve outcomes, but further study with more cases is needed.

Original languageEnglish
Pages (from-to)323-332
Number of pages10
JournalJournal of the Korean Society of Coloproctology
Volume25
Issue number5
DOIs
Publication statusPublished - 2009 Oct 1

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Gastrointestinal Stromal Tumors
Rectum
Colon
Colorectal Neoplasms
Recurrence
Neoplasms
Radiotherapy
Peritoneum
National Institutes of Health (U.S.)
Rectal Neoplasms
Survival Rate
Lymph Nodes
Outcome Assessment (Health Care)
Liver
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Choi, S. H., Kim, S. J., Choi, Y. J., Min, B. S., Kim, J. S., Baik, S. H., ... Kang, J. G. (2009). Clinicopathologic analysis of gastrointestinal stromal tumors of the colon and rectum. Journal of the Korean Society of Coloproctology, 25(5), 323-332. https://doi.org/10.3393/jksc.2009.25.5.323
Choi, Sung Hoon ; Kim, Seo Jeon ; Choi, Yun Jung ; Min, Byung So ; Kim, Jin Su ; Baik, Seung Hyuk ; Kim, Namkyu ; Kang, Jung Gu. / Clinicopathologic analysis of gastrointestinal stromal tumors of the colon and rectum. In: Journal of the Korean Society of Coloproctology. 2009 ; Vol. 25, No. 5. pp. 323-332.
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abstract = "Purpose: This study's aim is to investigate the clinicopathologic characteristics of colorectal gastrointestinal stromal tumors (GISTs) and to evaluate the result of those tumors. Methods: We retrospectively reviewed 22 patients who had been diagnosed with primary colorectal GISTs and who had undergone a surgical resection between October 1996 and July 2008. Results: Colorectal GISTs accounted for 0.28{\%} of all colorectal malignancies and 7.7{\%} of all GISTs. Rectal GISTs (19, 86.4{\%}) were more common than colonic GISTs (3, 13.6{\%}). According to the National Institute of Health's (NIH) grading system, there were 1 (4.5{\%}) very low, 5 (22.7{\%}) low, 4 (18.2{\%}) intermediate, and 12 (54.6{\%}) high-risk tumors. The disease recurred in 7 patients (1 with intermediate risk and 6 with high risk). Recurrence sites were the liver (42.9{\%}), the peritoneum (71.5{\%}), and the lymph nodes (14.3{\%}). Adjuvant imatinib therapy and/or radiation therapy were done for patients with microscopically positive margins of resection and high risk, of which one experienced a recurrence at 95 months after surgery. The five-year recurrence rates were 0{\%} in the very-low-grade and low-grade groups, 33.3{\%} in the intermediate-grade group, and 37.5{\%} in the high-grade group. The five-year overall survival rates were 100{\%} in the very-low-grade and low-grade groups, 66.7{\%} in the intermediate-grade group, and 62.5{\%} in the high-grade group. Conclusion: Poor prognosis of colorectal GISTs was closely related to the tumor's histologic grade and size. Integrating surgery, molecular therapy, and radiation therapy might improve outcomes, but further study with more cases is needed.",
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Clinicopathologic analysis of gastrointestinal stromal tumors of the colon and rectum. / Choi, Sung Hoon; Kim, Seo Jeon; Choi, Yun Jung; Min, Byung So; Kim, Jin Su; Baik, Seung Hyuk; Kim, Namkyu; Kang, Jung Gu.

In: Journal of the Korean Society of Coloproctology, Vol. 25, No. 5, 01.10.2009, p. 323-332.

Research output: Contribution to journalArticle

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AU - Choi, Sung Hoon

AU - Kim, Seo Jeon

AU - Choi, Yun Jung

AU - Min, Byung So

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AU - Baik, Seung Hyuk

AU - Kim, Namkyu

AU - Kang, Jung Gu

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N2 - Purpose: This study's aim is to investigate the clinicopathologic characteristics of colorectal gastrointestinal stromal tumors (GISTs) and to evaluate the result of those tumors. Methods: We retrospectively reviewed 22 patients who had been diagnosed with primary colorectal GISTs and who had undergone a surgical resection between October 1996 and July 2008. Results: Colorectal GISTs accounted for 0.28% of all colorectal malignancies and 7.7% of all GISTs. Rectal GISTs (19, 86.4%) were more common than colonic GISTs (3, 13.6%). According to the National Institute of Health's (NIH) grading system, there were 1 (4.5%) very low, 5 (22.7%) low, 4 (18.2%) intermediate, and 12 (54.6%) high-risk tumors. The disease recurred in 7 patients (1 with intermediate risk and 6 with high risk). Recurrence sites were the liver (42.9%), the peritoneum (71.5%), and the lymph nodes (14.3%). Adjuvant imatinib therapy and/or radiation therapy were done for patients with microscopically positive margins of resection and high risk, of which one experienced a recurrence at 95 months after surgery. The five-year recurrence rates were 0% in the very-low-grade and low-grade groups, 33.3% in the intermediate-grade group, and 37.5% in the high-grade group. The five-year overall survival rates were 100% in the very-low-grade and low-grade groups, 66.7% in the intermediate-grade group, and 62.5% in the high-grade group. Conclusion: Poor prognosis of colorectal GISTs was closely related to the tumor's histologic grade and size. Integrating surgery, molecular therapy, and radiation therapy might improve outcomes, but further study with more cases is needed.

AB - Purpose: This study's aim is to investigate the clinicopathologic characteristics of colorectal gastrointestinal stromal tumors (GISTs) and to evaluate the result of those tumors. Methods: We retrospectively reviewed 22 patients who had been diagnosed with primary colorectal GISTs and who had undergone a surgical resection between October 1996 and July 2008. Results: Colorectal GISTs accounted for 0.28% of all colorectal malignancies and 7.7% of all GISTs. Rectal GISTs (19, 86.4%) were more common than colonic GISTs (3, 13.6%). According to the National Institute of Health's (NIH) grading system, there were 1 (4.5%) very low, 5 (22.7%) low, 4 (18.2%) intermediate, and 12 (54.6%) high-risk tumors. The disease recurred in 7 patients (1 with intermediate risk and 6 with high risk). Recurrence sites were the liver (42.9%), the peritoneum (71.5%), and the lymph nodes (14.3%). Adjuvant imatinib therapy and/or radiation therapy were done for patients with microscopically positive margins of resection and high risk, of which one experienced a recurrence at 95 months after surgery. The five-year recurrence rates were 0% in the very-low-grade and low-grade groups, 33.3% in the intermediate-grade group, and 37.5% in the high-grade group. The five-year overall survival rates were 100% in the very-low-grade and low-grade groups, 66.7% in the intermediate-grade group, and 62.5% in the high-grade group. Conclusion: Poor prognosis of colorectal GISTs was closely related to the tumor's histologic grade and size. Integrating surgery, molecular therapy, and radiation therapy might improve outcomes, but further study with more cases is needed.

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