Abstract
Background: Conflicting results from previous studies on gastric adenocarcinoma (GC) in young patients have led to controversy surrounding the prognosis for young GC patients. Methods: The authors studied 6954 patients with GC who received curative resections. They were classified into three groups: those aged 40 years or less ("young," 12.7%); those aged 41-65 years ("middle-aged," 66.7%); and those aged more than 65 years ("elderly," 20.6%). Clinicopathologic characteristics and overall survival rates were analyzed. Results: Young patients were predominately female and had tumors that were histologically undifferentiated. However, in regard to T4 invasion, N3 lymph node metastasis, and TNM stage IV, the characteristics of the tumors of young patients were similar to those of middle-aged and elderly patients. Overall survival rate was significantly better in young patients than middle-aged patients (P = .018) and elderly patients (P < .001). Stratified by TNM stage, young patients showed better overall survival at stage I than middle-aged patients, and at stages I, II, and IIIa than elderly patients. Multivariate analysis indicated that age was an independent prognostic factor (as well as gender, operation type, depth of invasion, and lymph node status). Conclusions: The predominance of female cases and tumors that were histologically undifferentiated were distinctive characteristics in young patients. Young patients could gain a survival benefit after curative resection with stage I disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1464-1469 |
| Number of pages | 6 |
| Journal | Annals of Surgical Oncology |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2008 May 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
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Clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection. / Lai, Ji Fu; Kim, Sungsoo; Li, Chen; Oh, Sung Jin; Hyung, Woo Jin; Choi, Won Hyuk; Choi, Seung Ho; Wang, Lin Bo; Noh, Sung Hoon.
In: Annals of Surgical Oncology, Vol. 15, No. 5, 01.05.2008, p. 1464-1469.Research output: Contribution to journal › Article
TY - JOUR
T1 - Clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection
AU - Lai, Ji Fu
AU - Kim, Sungsoo
AU - Li, Chen
AU - Oh, Sung Jin
AU - Hyung, Woo Jin
AU - Choi, Won Hyuk
AU - Choi, Seung Ho
AU - Wang, Lin Bo
AU - Noh, Sung Hoon
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Background: Conflicting results from previous studies on gastric adenocarcinoma (GC) in young patients have led to controversy surrounding the prognosis for young GC patients. Methods: The authors studied 6954 patients with GC who received curative resections. They were classified into three groups: those aged 40 years or less ("young," 12.7%); those aged 41-65 years ("middle-aged," 66.7%); and those aged more than 65 years ("elderly," 20.6%). Clinicopathologic characteristics and overall survival rates were analyzed. Results: Young patients were predominately female and had tumors that were histologically undifferentiated. However, in regard to T4 invasion, N3 lymph node metastasis, and TNM stage IV, the characteristics of the tumors of young patients were similar to those of middle-aged and elderly patients. Overall survival rate was significantly better in young patients than middle-aged patients (P = .018) and elderly patients (P < .001). Stratified by TNM stage, young patients showed better overall survival at stage I than middle-aged patients, and at stages I, II, and IIIa than elderly patients. Multivariate analysis indicated that age was an independent prognostic factor (as well as gender, operation type, depth of invasion, and lymph node status). Conclusions: The predominance of female cases and tumors that were histologically undifferentiated were distinctive characteristics in young patients. Young patients could gain a survival benefit after curative resection with stage I disease.
AB - Background: Conflicting results from previous studies on gastric adenocarcinoma (GC) in young patients have led to controversy surrounding the prognosis for young GC patients. Methods: The authors studied 6954 patients with GC who received curative resections. They were classified into three groups: those aged 40 years or less ("young," 12.7%); those aged 41-65 years ("middle-aged," 66.7%); and those aged more than 65 years ("elderly," 20.6%). Clinicopathologic characteristics and overall survival rates were analyzed. Results: Young patients were predominately female and had tumors that were histologically undifferentiated. However, in regard to T4 invasion, N3 lymph node metastasis, and TNM stage IV, the characteristics of the tumors of young patients were similar to those of middle-aged and elderly patients. Overall survival rate was significantly better in young patients than middle-aged patients (P = .018) and elderly patients (P < .001). Stratified by TNM stage, young patients showed better overall survival at stage I than middle-aged patients, and at stages I, II, and IIIa than elderly patients. Multivariate analysis indicated that age was an independent prognostic factor (as well as gender, operation type, depth of invasion, and lymph node status). Conclusions: The predominance of female cases and tumors that were histologically undifferentiated were distinctive characteristics in young patients. Young patients could gain a survival benefit after curative resection with stage I disease.
UR - http://www.scopus.com/inward/record.url?scp=41549089944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41549089944&partnerID=8YFLogxK
U2 - 10.1245/s10434-008-9809-1
DO - 10.1245/s10434-008-9809-1
M3 - Article
C2 - 18340495
AN - SCOPUS:41549089944
VL - 15
SP - 1464
EP - 1469
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 5
ER -