Clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection

Ji Fu Lai, Sungsoo Kim, Chen Li, Sung Jin Oh, Woo Jin Hyung, Won Hyuk Choi, Seung Ho Choi, Lin Bo Wang, Sung Hoon Noh

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36 Citations (Scopus)

Abstract

Background: Conflicting results from previous studies on gastric adenocarcinoma (GC) in young patients have led to controversy surrounding the prognosis for young GC patients. Methods: The authors studied 6954 patients with GC who received curative resections. They were classified into three groups: those aged 40 years or less ("young," 12.7%); those aged 41-65 years ("middle-aged," 66.7%); and those aged more than 65 years ("elderly," 20.6%). Clinicopathologic characteristics and overall survival rates were analyzed. Results: Young patients were predominately female and had tumors that were histologically undifferentiated. However, in regard to T4 invasion, N3 lymph node metastasis, and TNM stage IV, the characteristics of the tumors of young patients were similar to those of middle-aged and elderly patients. Overall survival rate was significantly better in young patients than middle-aged patients (P = .018) and elderly patients (P < .001). Stratified by TNM stage, young patients showed better overall survival at stage I than middle-aged patients, and at stages I, II, and IIIa than elderly patients. Multivariate analysis indicated that age was an independent prognostic factor (as well as gender, operation type, depth of invasion, and lymph node status). Conclusions: The predominance of female cases and tumors that were histologically undifferentiated were distinctive characteristics in young patients. Young patients could gain a survival benefit after curative resection with stage I disease.

Original languageEnglish
Pages (from-to)1464-1469
Number of pages6
JournalAnnals of Surgical Oncology
Volume15
Issue number5
DOIs
Publication statusPublished - 2008 May 1

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Stomach
Adenocarcinoma
Survival Rate
Lymph Nodes
Neoplasms
Survival
Multivariate Analysis
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Lai, Ji Fu ; Kim, Sungsoo ; Li, Chen ; Oh, Sung Jin ; Hyung, Woo Jin ; Choi, Won Hyuk ; Choi, Seung Ho ; Wang, Lin Bo ; Noh, Sung Hoon. / Clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection. In: Annals of Surgical Oncology. 2008 ; Vol. 15, No. 5. pp. 1464-1469.
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Clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection. / Lai, Ji Fu; Kim, Sungsoo; Li, Chen; Oh, Sung Jin; Hyung, Woo Jin; Choi, Won Hyuk; Choi, Seung Ho; Wang, Lin Bo; Noh, Sung Hoon.

In: Annals of Surgical Oncology, Vol. 15, No. 5, 01.05.2008, p. 1464-1469.

Research output: Contribution to journalArticle

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T1 - Clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection

AU - Lai, Ji Fu

AU - Kim, Sungsoo

AU - Li, Chen

AU - Oh, Sung Jin

AU - Hyung, Woo Jin

AU - Choi, Won Hyuk

AU - Choi, Seung Ho

AU - Wang, Lin Bo

AU - Noh, Sung Hoon

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N2 - Background: Conflicting results from previous studies on gastric adenocarcinoma (GC) in young patients have led to controversy surrounding the prognosis for young GC patients. Methods: The authors studied 6954 patients with GC who received curative resections. They were classified into three groups: those aged 40 years or less ("young," 12.7%); those aged 41-65 years ("middle-aged," 66.7%); and those aged more than 65 years ("elderly," 20.6%). Clinicopathologic characteristics and overall survival rates were analyzed. Results: Young patients were predominately female and had tumors that were histologically undifferentiated. However, in regard to T4 invasion, N3 lymph node metastasis, and TNM stage IV, the characteristics of the tumors of young patients were similar to those of middle-aged and elderly patients. Overall survival rate was significantly better in young patients than middle-aged patients (P = .018) and elderly patients (P < .001). Stratified by TNM stage, young patients showed better overall survival at stage I than middle-aged patients, and at stages I, II, and IIIa than elderly patients. Multivariate analysis indicated that age was an independent prognostic factor (as well as gender, operation type, depth of invasion, and lymph node status). Conclusions: The predominance of female cases and tumors that were histologically undifferentiated were distinctive characteristics in young patients. Young patients could gain a survival benefit after curative resection with stage I disease.

AB - Background: Conflicting results from previous studies on gastric adenocarcinoma (GC) in young patients have led to controversy surrounding the prognosis for young GC patients. Methods: The authors studied 6954 patients with GC who received curative resections. They were classified into three groups: those aged 40 years or less ("young," 12.7%); those aged 41-65 years ("middle-aged," 66.7%); and those aged more than 65 years ("elderly," 20.6%). Clinicopathologic characteristics and overall survival rates were analyzed. Results: Young patients were predominately female and had tumors that were histologically undifferentiated. However, in regard to T4 invasion, N3 lymph node metastasis, and TNM stage IV, the characteristics of the tumors of young patients were similar to those of middle-aged and elderly patients. Overall survival rate was significantly better in young patients than middle-aged patients (P = .018) and elderly patients (P < .001). Stratified by TNM stage, young patients showed better overall survival at stage I than middle-aged patients, and at stages I, II, and IIIa than elderly patients. Multivariate analysis indicated that age was an independent prognostic factor (as well as gender, operation type, depth of invasion, and lymph node status). Conclusions: The predominance of female cases and tumors that were histologically undifferentiated were distinctive characteristics in young patients. Young patients could gain a survival benefit after curative resection with stage I disease.

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