Clinicopathologic Characteristics of Early Gastric Cancer in Korea

In Suh Park, Yongchan Lee, Won Ho Kim, Sung Hoon Noh, Kyong Sik Lee, Hoguen Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Gastric cancer is the most common cause of cancer related death in Korea. Early gastric cancer (EGC), confined to mucosa or submucosa, regardless of lymph node metastasis, is known to have a favorable prognosis. From 1976 to 1995, four thousand nine hundred and twenty eight gastric cancer patients underwent operation at the Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea. Of these, 1,117 patients (22.6%) were diagnosed as EGC and underwent curative operation. Clinicopathologic characteristics were reviewed and survival data was analyzed. The proportion of EGC has increased during the last two decades, from 14.9% during 1976-1985 to 25.8% for 1986-1995. EGC has a wide age distribution range from the thirties to the sixties, with highest incidence in the sixties. The male to female ratio is 1.8 : 1, without any significant change in last two decades. Most lesions are located in the lower third of stomach (52.3%), and the lesser curvature (52.2%) was the most frequent site in the transverse axis. Macroscopically, the depressed type was the most common (66.1%) followed by the elevated, flat and mixed types, in that order. Tumor confined to the mucosa layer was seen in 52.5%, and lymph node involvement in 11.7%. The depth of tumor invasion correlated with tumor size and regional lymph node involvement. On histopathologic examination, signet ring cell type accounted for 29.6% of all EGCs. Overall 5-year survival rate was 92.7% and the presence of lymph node metastasis significantly affected survival (84.6% versus 96.2%) (p<0.05). In conclusion, the proportion of EGC, in terms of the gastric cancers operated upon, has been increasing in Korea over the last two decades. The introduction of active diagnostic approaches and diagnostic modalities could improve early diagnosis and the cure rate of gastric cancer in Korea.

Original languageEnglish
Pages (from-to)607-614
Number of pages8
JournalYonsei Medical Journal
Volume41
Issue number5
DOIs
Publication statusPublished - 2000 Jan 1

Fingerprint

Korea
Stomach Neoplasms
Lymph Nodes
Neoplasms
Mucous Membrane
Neoplasm Metastasis
Survival
Age Distribution
Early Diagnosis
Stomach
Survival Rate
Medicine
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, In Suh ; Lee, Yongchan ; Kim, Won Ho ; Noh, Sung Hoon ; Lee, Kyong Sik ; Kim, Hoguen. / Clinicopathologic Characteristics of Early Gastric Cancer in Korea. In: Yonsei Medical Journal. 2000 ; Vol. 41, No. 5. pp. 607-614.
@article{ea191675088f4305b8ed56cf8ddf2bd7,
title = "Clinicopathologic Characteristics of Early Gastric Cancer in Korea",
abstract = "Gastric cancer is the most common cause of cancer related death in Korea. Early gastric cancer (EGC), confined to mucosa or submucosa, regardless of lymph node metastasis, is known to have a favorable prognosis. From 1976 to 1995, four thousand nine hundred and twenty eight gastric cancer patients underwent operation at the Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea. Of these, 1,117 patients (22.6{\%}) were diagnosed as EGC and underwent curative operation. Clinicopathologic characteristics were reviewed and survival data was analyzed. The proportion of EGC has increased during the last two decades, from 14.9{\%} during 1976-1985 to 25.8{\%} for 1986-1995. EGC has a wide age distribution range from the thirties to the sixties, with highest incidence in the sixties. The male to female ratio is 1.8 : 1, without any significant change in last two decades. Most lesions are located in the lower third of stomach (52.3{\%}), and the lesser curvature (52.2{\%}) was the most frequent site in the transverse axis. Macroscopically, the depressed type was the most common (66.1{\%}) followed by the elevated, flat and mixed types, in that order. Tumor confined to the mucosa layer was seen in 52.5{\%}, and lymph node involvement in 11.7{\%}. The depth of tumor invasion correlated with tumor size and regional lymph node involvement. On histopathologic examination, signet ring cell type accounted for 29.6{\%} of all EGCs. Overall 5-year survival rate was 92.7{\%} and the presence of lymph node metastasis significantly affected survival (84.6{\%} versus 96.2{\%}) (p<0.05). In conclusion, the proportion of EGC, in terms of the gastric cancers operated upon, has been increasing in Korea over the last two decades. The introduction of active diagnostic approaches and diagnostic modalities could improve early diagnosis and the cure rate of gastric cancer in Korea.",
author = "Park, {In Suh} and Yongchan Lee and Kim, {Won Ho} and Noh, {Sung Hoon} and Lee, {Kyong Sik} and Hoguen Kim",
year = "2000",
month = "1",
day = "1",
doi = "10.3349/ymj.2000.41.5.607",
language = "English",
volume = "41",
pages = "607--614",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "5",

}

Clinicopathologic Characteristics of Early Gastric Cancer in Korea. / Park, In Suh; Lee, Yongchan; Kim, Won Ho; Noh, Sung Hoon; Lee, Kyong Sik; Kim, Hoguen.

In: Yonsei Medical Journal, Vol. 41, No. 5, 01.01.2000, p. 607-614.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinicopathologic Characteristics of Early Gastric Cancer in Korea

AU - Park, In Suh

AU - Lee, Yongchan

AU - Kim, Won Ho

AU - Noh, Sung Hoon

AU - Lee, Kyong Sik

AU - Kim, Hoguen

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Gastric cancer is the most common cause of cancer related death in Korea. Early gastric cancer (EGC), confined to mucosa or submucosa, regardless of lymph node metastasis, is known to have a favorable prognosis. From 1976 to 1995, four thousand nine hundred and twenty eight gastric cancer patients underwent operation at the Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea. Of these, 1,117 patients (22.6%) were diagnosed as EGC and underwent curative operation. Clinicopathologic characteristics were reviewed and survival data was analyzed. The proportion of EGC has increased during the last two decades, from 14.9% during 1976-1985 to 25.8% for 1986-1995. EGC has a wide age distribution range from the thirties to the sixties, with highest incidence in the sixties. The male to female ratio is 1.8 : 1, without any significant change in last two decades. Most lesions are located in the lower third of stomach (52.3%), and the lesser curvature (52.2%) was the most frequent site in the transverse axis. Macroscopically, the depressed type was the most common (66.1%) followed by the elevated, flat and mixed types, in that order. Tumor confined to the mucosa layer was seen in 52.5%, and lymph node involvement in 11.7%. The depth of tumor invasion correlated with tumor size and regional lymph node involvement. On histopathologic examination, signet ring cell type accounted for 29.6% of all EGCs. Overall 5-year survival rate was 92.7% and the presence of lymph node metastasis significantly affected survival (84.6% versus 96.2%) (p<0.05). In conclusion, the proportion of EGC, in terms of the gastric cancers operated upon, has been increasing in Korea over the last two decades. The introduction of active diagnostic approaches and diagnostic modalities could improve early diagnosis and the cure rate of gastric cancer in Korea.

AB - Gastric cancer is the most common cause of cancer related death in Korea. Early gastric cancer (EGC), confined to mucosa or submucosa, regardless of lymph node metastasis, is known to have a favorable prognosis. From 1976 to 1995, four thousand nine hundred and twenty eight gastric cancer patients underwent operation at the Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea. Of these, 1,117 patients (22.6%) were diagnosed as EGC and underwent curative operation. Clinicopathologic characteristics were reviewed and survival data was analyzed. The proportion of EGC has increased during the last two decades, from 14.9% during 1976-1985 to 25.8% for 1986-1995. EGC has a wide age distribution range from the thirties to the sixties, with highest incidence in the sixties. The male to female ratio is 1.8 : 1, without any significant change in last two decades. Most lesions are located in the lower third of stomach (52.3%), and the lesser curvature (52.2%) was the most frequent site in the transverse axis. Macroscopically, the depressed type was the most common (66.1%) followed by the elevated, flat and mixed types, in that order. Tumor confined to the mucosa layer was seen in 52.5%, and lymph node involvement in 11.7%. The depth of tumor invasion correlated with tumor size and regional lymph node involvement. On histopathologic examination, signet ring cell type accounted for 29.6% of all EGCs. Overall 5-year survival rate was 92.7% and the presence of lymph node metastasis significantly affected survival (84.6% versus 96.2%) (p<0.05). In conclusion, the proportion of EGC, in terms of the gastric cancers operated upon, has been increasing in Korea over the last two decades. The introduction of active diagnostic approaches and diagnostic modalities could improve early diagnosis and the cure rate of gastric cancer in Korea.

UR - http://www.scopus.com/inward/record.url?scp=0034293474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034293474&partnerID=8YFLogxK

U2 - 10.3349/ymj.2000.41.5.607

DO - 10.3349/ymj.2000.41.5.607

M3 - Article

VL - 41

SP - 607

EP - 614

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 5

ER -